DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ss and ahrra

DIOPT Version :9

Sequence 1:	NP_001163629.2	Gene:	ss / 41988	FlyBaseID:	FBgn0003513	Length:	1015	Species:	Drosophila melanogaster
Sequence 2:	NP_001030342.1	Gene:	ahrra / 641291	ZFINID:	ZDB-GENE-051018-1	Length:	550	Species:	Danio rerio

Alignment Length:	521	Identity:	156/521 - (29%)
Similarity:	224/521 - (42%)	Gaps:	156/521 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VYATKRRRRNGKSLKPPPKDGVTKSNPSKRHRERLNAELDLLASLLPFEQNILSKLDRLSILRLS 71
            :||.::||:..:..||..... .||||||||||||||||:.||.||||..:.:.|||:||:||||
Zfish     8 LYAGRKRRKPIQKQKPAALMS-EKSNPSKRHRERLNAELERLAELLPFGPDTVCKLDKLSVLRLS 71

  Fly    72 VSYLRTKSYFQVVMH---------KDKEDN--GVLPHIHAHDGYRTRELGAFEHGLLDGDMFLQA 125
            |||||.||:..|:..         |:::|.  ..:|                     :..:.|::
Zfish    72 VSYLRIKSFCSVLAQENPCETQTSKNQQDTPAACVP---------------------ESQLLLES 115

  Fly   126 LNGFLMILTCEGEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLWNSFLP-ADMS 189
            |.||.::::.:|.||:|:.:|..||||||:|::||:|::.:|.:||:|.:|||.|....| .:..
Zfish   116 LAGFALVVSGDGMVFYASSTIADYLGFHQTDVMHQNVFDYIHVDDRQEFRRQLHWAMNPPNPEAQ 180

  Fly   190 SMQLAETLA--------------PDKALYLERSFTVRFRCLLDNTSGFLRLDIRGRIKVLHGQNR 240
            |...||..|              |:.:.:|.|.|.:|.|||||:|||||.:..:|::|.||||.|
Zfish   181 SSGTAEEFAVSSLFQSDQPAGVPPELSCFLSRCFILRVRCLLDSTSGFLTMQFQGQLKFLHGQRR 245

  Fly   241 KTEE-----PPLALFAYCTPF---GP----------PSLLEIPH---KENMFK--SKHKLDFS-- 280
            :...     |.||||....|.   ||          |..|.:|.   :|:..:  ..|.| ||
Zfish   246 RAVSGAALPPALALFCVAVPLLPSGPDLKMRSRQRGPGALPVPQHTDREDPLRRAGTHTL-FSRD 309

  Fly   281 --------LVSMDQ-----------------RGKHI------LGYADAELVNMGGYDLVHYDDLA 314
                    |.:.||                 |..|.      .||:.||.|......  |.||.
Zfish   310 AVKRRTEGLYAADQPQSVWPRTAPAVDMTARRHTHYGKPSRSAGYSRAECVEFSFQP--HGDDY- 371

  Fly   315 YVASAHQELLK--------------TGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPDFVICT 365
               :.|..||:              :||.|    ||....|..:...|......:.:       |
Zfish   372 ---NTHTHLLEPQVKLEPDSDCENGSGACG----RYNTHGGACERYNTHGAACERYN-------T 422

  Fly   366 H----RQLMDEEGHDLLGKRTMDFKVSYLDTGLASTYFSEADQLVVPPSTSPTAHALPPPVTPTR 426
            |    .:.....||..:|.:..      |:.|....:   :.|.:.||.   ..|...||    |
Zfish   423 HGAACERYNSAGGHTHMGAQVK------LEDGFGQQF---SCQRMKPPY---AGHYYTPP----R 471

  Fly   427 P 427
            |
Zfish   472 P 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ss	NP_001163629.2	HLH	35..76	CDD:197674	29/40 (73%)
		PAS	123..178	CDD:214512	24/54 (44%)
		PAS_3	282..366	CDD:285623	22/120 (18%)
		PAS	<291..369	CDD:238075	20/101 (20%)
ahrra	NP_001030342.1	HLH	35..76	CDD:197674	29/40 (73%)
		PAS	110..173	CDD:214512	27/62 (44%)
		PAS	110..>173	CDD:279347	27/62 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10649
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100