Protein Alignment ss and Ahrr

DIOPT Version :10

• Sequence 1: NP_001163629.2
• Gene: ss / 41988
• FlyBaseID: FBgn0003513
• Length: 1015
• Species: Drosophila melanogaster
• Sequence 2: NP_001019456.1
• Gene: Ahrr / 498999
• RGDID: 1559857
• Length: 701
• Species: Rattus norvegicus
• Alignment Length: 720
• Identity: 204/720 - (28%)
• Similarity: 304/720 - (42%)
• Gaps: 180/720 - (25%)

  Fly     8 YATKRRRRNGKSLKPPPKD----GVTKSNPSKRHRERLNAELDLLASLLPFEQNILSKLDRLSIL 68
            ||.::||      ||..|.    |..|||||||||:|||.|||.|||||||..:|:||||:||:|
  Rat    10 YAGRKRR------KPIQKRRLTMGTEKSNPSKRHRDRLNTELDHLASLLPFSPDIISKLDKLSVL 68

  Fly    69 RLSVSYLRTKSYFQVVMHKDKEDNGVL-PHIHAHDGYRTRELGAFEHGLLDGDMFLQALNGFLMI 132
            ||||||||.||:||.:..........| |..|:..|:..:|          |.:.|::||||.::
  Rat    69 RLSVSYLRVKSFFQALQETCVWSAPALSPEDHSSRGFPVQE----------GRLLLESLNGFALV 123

  Fly   133 LTCEGEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLW----------------- 180
            ::.||.:|:|:.:|..||||||:|::||::|:.:|.:||::..|||.|
  Rat   124 VSAEGMIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQSPHADT 188

  Fly   181 -NSFLPADMSSMQLAETLAPDKALYLERSFTVRFRCLLDNTSGFLRLDIRGRIKVLHGQNRKTEE 244
             |:.|...:.:.:..:.|..:.:.:|.|.|..|.|||||:|||||.:..:|::|.|.||.:||..
  Rat   189 DNTVLGKLLRAQEGGKGLPSEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKTPS 253

  Fly   245 -----PPLALFAYCTPFGPPSLLEIPHKENMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMGG 304
                 |.|:||....|. .||:.|:..|....|:||:.|. :|:||.|.|.:....::||
  Rat   254 GTALPPRLSLFCIVAPV-LPSVTEMKMKSAFLKAKHRADI-VVTMDSRAKAVTSLCESEL----- 311

  Fly   305 YDLVHYDDLAYVASAHQELLKTGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPDFVICTHRQL 369
                 :..|.|:|..     ..|.:.:..:|.|.....|......|..:.....||        |
  Rat   312 -----HPKLNYLAGR-----SNGENVISLFRGQTDRSHWTRALARSSCLCLRGGPD--------L 358

  Fly   370 MDEEGHDLLGKRTMDFKVSYLDTGLASTYFSEADQLVVPPSTSPTAHALPPPVTPTRPNRRYKTQ 434
            :|.:|..  |.|                  .|.||          .|.|     ...|..|.:.:
  Rat   359 LDPKGTS--GDR------------------EEDDQ----------KHIL-----RRSPGARGQRE 388

  Fly   435 LRDF---LSTCRSKRKLQQQNQPQTQQ-TSPLGGQVGSPAPAVAV----EYLPDPAAAVAAAYSN 491
            :..:   |.|....|.|....:.::|: |:.|..|.....|:..:    ..:|.|.:....:.||
  Rat   389 MHKYSYGLETPVHLRHLDWSTEQRSQEGTTKLTRQPSKSEPSTCLVPHGSCVPYPGSQGMFSASN 453

  Fly   492 LNPM-----YTTSPYASAAD----NLYMGSSMPANAFYPVSENLFHQYRLQGAVGGYYTDYPHSG 547
            :...     :.|..|.|..:    :::.|...|:....|           ||::|   :..|.||
  Rat   454 MASFRESLDHPTGTYCSQMNRPLPDIHQGQVDPSTCHIP-----------QGSLG---SRIPLSG 504

  Fly   548 APASAYVANGFLSYDGYAIASKADEKWQETGKYYSGYSSGYGSPTS--TPQQIPLKTPKSSPQVM 610
              ...:.|.||         |..|.|       ........|:|.:  ...::|:|        |
  Rat   505 --MQCFTARGF---------STEDAK-------LPSLPVNIGTPCNPVLSLEVPIK--------M 543

  Fly   611 EVISCSSDGPSPVGGATPN----GVGSVTPKVELAGTTAAAAAGQDPYERQTVLMWGTTHSSGVP 671
            |..|.|.|   .|..:|.:    |.|.:|.: .|.|..|......:|..||.|.         .|
  Rat   544 ENESGSQD---IVEASTTSCVWLGTGDMTRR-HLVGFPARMHLKTEPDYRQQVC---------TP 595

  Fly   672 LNSHG 676
            ...||
  Rat   596 HRGHG 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ss	NP_001163629.2	bHLH-PAS_spineless_like	24..87	CDD:381573	44/66 (67%)
		PAS	123..178	CDD:214512	24/54 (44%)
		PAS_3	282..366	CDD:430001	17/83 (20%)
Ahrr	NP_001019456.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		15/33 (45%)
		bHLH-PAS_AhRR	27..86	CDD:381441	43/58 (74%)
		PAS	108..174	CDD:214512	29/75 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..389		11/63 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..436		5/26 (19%)
		Needed for transcriptional repression. /evidence=ECO:0000250	555..701		14/56 (25%)