DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ss and Ahrr

DIOPT Version :9

Sequence 1:	NP_001163629.2	Gene:	ss / 41988	FlyBaseID:	FBgn0003513	Length:	1015	Species:	Drosophila melanogaster
Sequence 2:	NP_001019456.1	Gene:	Ahrr / 498999	RGDID:	1559857	Length:	701	Species:	Rattus norvegicus

Alignment Length:	720	Identity:	204/720 - (28%)
Similarity:	304/720 - (42%)	Gaps:	180/720 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YATKRRRRNGKSLKPPPKD----GVTKSNPSKRHRERLNAELDLLASLLPFEQNILSKLDRLSIL 68
            ||.::||      ||..|.    |..|||||||||:|||.|||.|||||||..:|:||||:||:|
  Rat    10 YAGRKRR------KPIQKRRLTMGTEKSNPSKRHRDRLNTELDHLASLLPFSPDIISKLDKLSVL 68

  Fly    69 RLSVSYLRTKSYFQVVMHKDKEDNGVL-PHIHAHDGYRTRELGAFEHGLLDGDMFLQALNGFLMI 132
            ||||||||.||:||.:..........| |..|:..|:..:|          |.:.|::||||.::
  Rat    69 RLSVSYLRVKSFFQALQETCVWSAPALSPEDHSSRGFPVQE----------GRLLLESLNGFALV 123

  Fly   133 LTCEGEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLW----------------- 180
            ::.||.:|:|:.:|..||||||:|::||::|:.:|.:||::..|||.|
  Rat   124 VSAEGMIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQSPHADT 188

  Fly   181 -NSFLPADMSSMQLAETLAPDKALYLERSFTVRFRCLLDNTSGFLRLDIRGRIKVLHGQNRKTEE 244
             |:.|...:.:.:..:.|..:.:.:|.|.|..|.|||||:|||||.:..:|::|.|.||.:||..
  Rat   189 DNTVLGKLLRAQEGGKGLPSEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKTPS 253

  Fly   245 -----PPLALFAYCTPFGPPSLLEIPHKENMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMGG 304
                 |.|:||....|. .||:.|:..|....|:||:.|. :|:||.|.|.:....::||
  Rat   254 GTALPPRLSLFCIVAPV-LPSVTEMKMKSAFLKAKHRADI-VVTMDSRAKAVTSLCESEL----- 311

  Fly   305 YDLVHYDDLAYVASAHQELLKTGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPDFVICTHRQL 369
                 :..|.|:|..     ..|.:.:..:|.|.....|......|..:.....||        |
  Rat   312 -----HPKLNYLAGR-----SNGENVISLFRGQTDRSHWTRALARSSCLCLRGGPD--------L 358

  Fly   370 MDEEGHDLLGKRTMDFKVSYLDTGLASTYFSEADQLVVPPSTSPTAHALPPPVTPTRPNRRYKTQ 434
            :|.:|..  |.|                  .|.||          .|.|     ...|..|.:.:
  Rat   359 LDPKGTS--GDR------------------EEDDQ----------KHIL-----RRSPGARGQRE 388

  Fly   435 LRDF---LSTCRSKRKLQQQNQPQTQQ-TSPLGGQVGSPAPAVAV----EYLPDPAAAVAAAYSN 491
            :..:   |.|....|.|....:.::|: |:.|..|.....|:..:    ..:|.|.:....:.||
  Rat   389 MHKYSYGLETPVHLRHLDWSTEQRSQEGTTKLTRQPSKSEPSTCLVPHGSCVPYPGSQGMFSASN 453

  Fly   492 LNPM-----YTTSPYASAAD----NLYMGSSMPANAFYPVSENLFHQYRLQGAVGGYYTDYPHSG 547
            :...     :.|..|.|..:    :::.|...|:....|           ||::|   :..|.||
  Rat   454 MASFRESLDHPTGTYCSQMNRPLPDIHQGQVDPSTCHIP-----------QGSLG---SRIPLSG 504

  Fly   548 APASAYVANGFLSYDGYAIASKADEKWQETGKYYSGYSSGYGSPTS--TPQQIPLKTPKSSPQVM 610
              ...:.|.||         |..|.|       ........|:|.:  ...::|:|        |
  Rat   505 --MQCFTARGF---------STEDAK-------LPSLPVNIGTPCNPVLSLEVPIK--------M 543

  Fly   611 EVISCSSDGPSPVGGATPN----GVGSVTPKVELAGTTAAAAAGQDPYERQTVLMWGTTHSSGVP 671
            |..|.|.|   .|..:|.:    |.|.:|.: .|.|..|......:|..||.|.         .|
  Rat   544 ENESGSQD---IVEASTTSCVWLGTGDMTRR-HLVGFPARMHLKTEPDYRQQVC---------TP 595

  Fly   672 LNSHG 676
            ...||
  Rat   596 HRGHG 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ss	NP_001163629.2	HLH	35..76	CDD:197674	31/40 (78%)
		PAS	123..178	CDD:214512	24/54 (44%)
		PAS_3	282..366	CDD:285623	17/83 (20%)
		PAS	<291..369	CDD:238075	12/77 (16%)
Ahrr	NP_001019456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		15/33 (45%)
		HLH	35..86	CDD:197674	37/50 (74%)
		PAS	108..174	CDD:214512	29/75 (39%)
		PAS	108..>173	CDD:279347	29/74 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..389		11/63 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..436		5/26 (19%)
		Needed for transcriptional repression. /evidence=ECO:0000250	555..701		14/56 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341040
Domainoid	1	1.000	86	1.000	Domainoid score	I7913
eggNOG	1	0.900	-	-		E1_KOG3560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10649
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.800