Protein Alignment ss and ARNT

DIOPT Version :10

• Sequence 1: NP_001163629.2
• Gene: ss / 41988
• FlyBaseID: FBgn0003513
• Length: 1015
• Species: Drosophila melanogaster
• Sequence 2: NP_001659.1
• Gene: ARNT / 405
• HGNCID: 700
• Length: 789
• Species: Homo sapiens
• Alignment Length: 831
• Identity: 176/831 - (21%)
• Similarity: 293/831 - (35%)
• Gaps: 248/831 - (29%)

  Fly    11 KRRRRNGKSLKPPPKDGVTKSNPS---KRHRERLNAELDLLASLLPFEQNILSKLDRLSILRLSV 72
            :|..|:........|:.:.:.|.|   :|.|.::.|.:..|:.::|....:..|.|:|:|||::|
Human    72 ERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136

  Fly    73 SYLR---------TKSYFQVVMHKDKEDNGVLPHIHAHDGYRTRELGAFEHGLLDGDMFLQALNG 128
            |:::         |...::.....|:|    |.|                       :.|:|.:|
Human   137 SHMKSLRGTGNTSTDGSYKPSFLTDQE----LKH-----------------------LILEAADG 174

  Fly   129 FLMILTCE-GEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQL------LWNSFL-- 184
            ||.|::|| |.|.:.:.|:...|...||:....::|:.||.:|.::|:.||      |....|
Human   175 FLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDL 239

  Fly   185 -------PADMSSMQLAETLAPDKALYLERSFTVRFRCLLDNTSGFLRLD---------IRGRIK 233
                   ....|||::        .:...|||..|.||      |...:|         :|.|.:
Human   240 KTGTVKKEGQQSSMRM--------CMGSRRSFICRMRC------GSSSVDPVSVNRLSFVRNRCR 290

  Fly   234 VLHGQNRKTEEPPLALFAYCTPF---GPPSLLEIPHKE--------------------------- 268
              :|.....:..|..:..:||.:   .||:.:.:|..:
Human   291 --NGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTD 353

  Fly   269 -------NMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMGGYDLVHYDDLAYVASAHQELLK- 325
                   ..|.|:|.::.....:|.|....:||...||:.....:..|.:|...:..:.|:::|
Human   354 MSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKL 418

  Fly   326 TGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPD---FVICTHRQLMD---------------- 371
            .|....:.:|::.|:.||.|::||| ..::|...|   ::|||:..:.:
Human   419 KGQVLSVMFRFRSKNQEWLWMRTSS-FTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRP 482

  Fly   372 ----------EEGHDLLGKRTMDFKVSYLD-----TGLASTYFSEADQLVVPPSTSPTAHALPPP 421
                      |.|...|..|... :.:.||     .||||...|   |:|.|.:|:...|:
Human   483 QLGPTANLPLEMGSGQLAPRQQQ-QQTELDMVPGRDGLASYNHS---QVVQPVTTTGPEHS---- 539

  Fly   422 VTPTRPNRRYKTQLRD--------FLSTCRSKRKLQQQNQPQTQQTSPLGGQVGSPAPAVAVEYL 478
             .|...:.....|.||        .::..:|| .:.....|.|||....|.           .:.
Human   540 -KPLEKSDGLFAQDRDPRFSEIYHNINADQSK-GISSSTVPATQQLFSQGN-----------TFP 591

  Fly   479 PDPAAAVAAAYSNLNPMYT-TSPYASAADNLYMGSSMPANAFYPVSENLFHQYRLQGAVGGYYTD 542
            |.|..|.....|.|.|..| ..|.|||...|...|.              |....|||. ..:|.
Human   592 PTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISR--------------HSNPTQGAT-PTWTP 641

  Fly   543 YPHSGAPASAYVANGFLSYDGYAIASKADEKWQETGKYYSGYSSGYGSPTSTPQQIPLKTPKSSP 607
            ...||             :....:|::|..| ..|.::..|   .:.:|:|.........|.:||
Human   642 TTRSG-------------FSAQQVATQATAK-TRTSQFGVG---SFQTPSSFSSMSLPGAPTASP 689

  Fly   608 QVMEVISCSSDGP--SPVGG--------ATPNGVGSVTPKVELAGTTAAAAAGQDPYERQTVLMW 662
            ......|.::.|.  :|..|        .|..||| |.|:.:          ||.|:.|.:
Human   690 GAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVG-VWPQWQ----------GQQPHHRSS---- 739

  Fly   663 GTTHSSGVPLNSHGGRTGAGNPASPQRSTPLGNGLGYASANNNNNDLEPAT 713
                ||    ..|..:..|..|..|:....:.:.||..|.:.||.:....|
Human   740 ----SS----EQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPDLT 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ss	NP_001163629.2	bHLH-PAS_spineless_like	24..87	CDD:381573	17/74 (23%)
		PAS	123..178	CDD:214512	19/55 (35%)
		PAS_3	282..366	CDD:430001	23/87 (26%)
ARNT	NP_001659.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..97		5/24 (21%)
		bHLH-PAS_ARNT	86..150	CDD:381517	16/63 (25%)
		DNA-binding. /evidence=ECO:0000269|PubMed:28396409	88..128		8/39 (21%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250|UniProtKB:P53762	112..264		43/186 (23%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250|UniProtKB:P53762	112..168		15/82 (18%)
		PAS	163..269	CDD:395786	33/140 (24%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250|UniProtKB:P53762	167..171		1/3 (33%)
		PAS_11	362..462	CDD:464214	27/100 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	465..492		0/26 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	672..789		31/134 (23%)