DRSC/TRiP Functional Genomics Resources

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Protein Alignment ss and Arnt

DIOPT Version :10

Sequence 1:NP_001163629.2 Gene:ss / 41988 FlyBaseID:FBgn0003513 Length:1015 Species:Drosophila melanogaster
Sequence 2:NP_036912.3 Gene:Arnt / 25242 RGDID:2153 Length:809 Species:Rattus norvegicus


Alignment Length:940 Identity:186/940 - (19%)
Similarity:318/940 - (33%) Gaps:319/940 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 KRRRRNGKSLKPPPKDGVTKSNPS---KRHRERLNAELDLLASLLPFEQNILSKLDRLSILRLSV 72
            :|..|:........|:.:.:.|.|   :|.|.::.|.:..|:.::|....:..|.|:|:|||::|
  Rat    72 ERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136

  Fly    73 SYLR---------TKSYFQVVMHKDKEDNGVLPHIHAHDGYRTRELGAFEHGLLDGDMFLQALNG 128
            |:::         |...::.....|:|    |.|                       :.|:|.:|
  Rat   137 SHMKSLRGTGNTSTDGSYKPSFLTDQE----LKH-----------------------LILEAADG 174

  Fly   129 FLMILTCE-GEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQL------LWNSFL-- 184
            ||.|::|| |.|.:.:.|:...|...||:....::|:.||.:|.::|:.||      |....|  
  Rat   175 FLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDL 239

  Fly   185 -------PADMSSMQLAETLAPDKALYLERSFTVRFRC-------LLDNTSGFLRLDIRGRIKVL 235
                   ....|||::        .:...|||..|.||       :..|...|||...|      
  Rat   240 KTGTVKKEGQQSSMRM--------CMGSRRSFICRMRCGTSSVDPVSMNRLSFLRNRCR------ 290

  Fly   236 HGQNRKTEEPPLALFAYCTPF---GPPSLLEIPHKE----------------------------- 268
            :|.....|..|..:..:||.:   .||:.:.:|..:                             
  Rat   291 NGLGSVKEGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMS 355

  Fly   269 -----NMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMGGYDLVHYDDLAYVASAHQELLK-TG 327
                 ..|.|:|.::.....:|.|....:||...||:.....:..|.:|...:..:.|:::| .|
  Rat   356 NICQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG 420

  Fly   328 ASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPD---FVICTHRQLMDEEGHDLLGKRTMDFKVSY 389
            ....:.:|::.|:.||.|::||| ..::|...|   ::|||:..:.:.....   :.|:...:..
  Rat   421 QVLSVMFRFRAKNREWLWMRTSS-FTFQNPYSDEIEYIICTNTNVKNSSQEP---RPTLSNTIQR 481

  Fly   390 LDTGLASTYFSEADQLVVPPSTSPTAHALPPPVTPTRPNRRYKTQLRDFLSTCRSKRKLQQQNQP 454
            ...|                   ||.:......|....:|:.:.|.:.     :.:::.|||.|.
  Rat   482 SQLG-------------------PTTNLSLEMGTGQLASRQQQQQQQQ-----QQQQQQQQQQQQ 522

  Fly   455 QTQQTSPLGGQVGSPAPA------VAVEYLPDPAAAVAAAYS------------NLNPMYT-TSP 500
            |.||.:.|....|....|      |:|:    |.|...:.:|            :.:|.:: ..|
  Rat   523 QQQQQTELDMVPGRDGLASYSHSQVSVQ----PVATAGSEHSKPLEKSEGLFVQDRDPRFSEIYP 583

  Fly   501 YASAADNLYMGSSMPANAFYPVSENLFHQYRLQGAVGGYYTDYPHSGAPASAYVANGFLSYDGYA 565
            ..||..:..:.||.     .|.::.||.|          .:.:|.:..||..:..:|.       
  Rat   584 NISADQSKGLSSST-----VPATQQLFSQ----------GSSFPPNPRPAENFRNSGL------- 626

  Fly   566 IASKADEKWQETGKYYSGYSSGYGSPTSTPQQIPLKTPKSSPQVMEVISCSSDGPSPVGGATPNG 630
                                        ||....::...|:.|::..||..|   :...|:.|..
  Rat   627 ----------------------------TPPVTIVQPSSSAGQILAQISRHS---NLTQGSAPTW 660

  Fly   631 VGSVTPKVELAGTTAAAAAGQDPYERQTVLMWGTTHSSGVPLNSHGGRTGAGNPASPQRSTPLGN 695
            ..|..|.......|.|.|               .|.||...:|:.  :|.:...|......|..:
  Rat   661 TSSTRPGFSAQLPTQATA---------------KTRSSQFGVNNF--QTSSSFSAMSLPGAPTAS 708

  Fly   696 GLGYASANNNNNDLEPATAAKWNGTKELPGKSGSASTPESYQMQHDDSGLYSASSHTTSPQQQQQ 760
                           |:|||    ...||.: ||...||:.|               |:.|.|  
  Rat   709 ---------------PSTAA----YPTLPNR-GSNFPPETGQ---------------TTGQFQ-- 736

  Fly   761 QQLQQSQRGVGSNVSAPSSSLTSTGTDQQAVHPSSCHQQQQQQQQQHHHAHPHPHSHHHHHHHHH 825
               .::..|||                   |.|      |.|.||.||.:        ..:..|.
  Rat   737 ---TRTAEGVG-------------------VWP------QWQGQQPHHRS--------SSNEQHV 765

  Fly   826 HETAHQHSSEIILTTHHQQQSQQQQQSLAG 855
            ..|:.|.||        |.:..|:..|:.|
  Rat   766 QPTSAQPSS--------QPEVFQEMLSMLG 787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ssNP_001163629.2 bHLH-PAS_spineless_like 24..87 CDD:381573 17/74 (23%)
PAS 123..178 CDD:214512 19/55 (35%)
PAS_3 282..366 CDD:430001 23/87 (26%)
ArntNP_036912.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 73..95 4/21 (19%)
bHLH-PAS_ARNT 86..150 CDD:381517 16/63 (25%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:P53762 88..128 8/39 (21%)
Required for heterodimer formation with EPAS1. /evidence=ECO:0000250|UniProtKB:P53762 112..264 43/186 (23%)
Required for heterodimer formation with HIF1A. /evidence=ECO:0000250|UniProtKB:P53762 112..168 15/82 (18%)
PAS 163..269 CDD:395786 33/140 (24%)
Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250|UniProtKB:P53762 167..171 1/3 (33%)
PAS_11 362..462 CDD:464214 27/100 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..487 2/43 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 545..575 5/33 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 653..685 10/46 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..735 13/70 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..809 15/56 (27%)
Blue background indicates that the domain is not in the aligned region.

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