DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ss and AHR

DIOPT Version :9

Sequence 1:	NP_001163629.2	Gene:	ss / 41988	FlyBaseID:	FBgn0003513	Length:	1015	Species:	Drosophila melanogaster
Sequence 2:	NP_001612.1	Gene:	AHR / 196	HGNCID:	348	Length:	848	Species:	Homo sapiens

Alignment Length:	929	Identity:	274/929 - (29%)
Similarity:	411/929 - (44%)	Gaps:	208/929 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SQLGTVYATKRRRRN-GKSLKPPPKDGVTKSNPSKRHRERLNAELDLLASLLPFEQNILSKLDRL 65
            |.....||:::||:. .|::||.|.:|: |||||||||:|||.|||.|||||||.|::::|||:|
Human     4 SSANITYASRKRRKPVQKTVKPIPAEGI-KSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKL 67

  Fly    66 SILRLSVSYLRTKSYFQVVMHKD-KEDNGVLPHIHAHDGYRTRELGAFEHG--LLDGDMFLQALN 127
            |:|||||||||.||:|.|.:... .|.||      ..|..|...   |..|  |.:|:..|||||
Human    68 SVLRLSVSYLRAKSFFDVALKSSPTERNG------GQDNCRAAN---FREGLNLQEGEFLLQALN 123

  Fly   128 GFLMILTCEGEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLWNSFLPADMS--- 189
            ||::::|.:..||:|:.:|:.||||.|||::|||||||:|:|||.|.||||.| :..|:..:
Human   124 GFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHW-ALNPSQCTESG 187

  Fly   190 -----SMQLAET--------LAPDKALYLERSFTVRFRCLLDNTSGFLRLDIRGRIKVLHGQNRK 241
                 :..|.:|        :.|:.:..:||.|..|.||||||:||||.::.:|::|.||||.:|
Human   188 QGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKK 252

  Fly   242 TEE-----PPLALFAYCTPFGPPSLLEIPHKENMFKSKHKLDFSLVSMDQRGKHILGYADAELVN 301
            .::     |.|||||..||..|||:|||..|..:|::||||||:.:..|.:|:.:|||.:|||..
Human   253 GKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCT 317

  Fly   302 MG-GYDLVHYDDLAYVASAHQELLKTGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPDFVICT 365
            .| ||..:|..|:.|.|.:|..::|||.||||.:|...|:..|.|:|:::||:|||.:||::|.|
Human   318 RGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYKNGRPDYIIVT 382

  Fly   366 HRQLMDEEGHDLLGKRTMDFKVSYL-DTGLASTYFSEADQLVVPPSTSPTAHALPP-PV-----T 423
            .|.|.||||.:.|.||  :.|:.:: .||.|..|          .:|:|....:.| |:     |
Human   383 QRPLTDEEGTEHLRKR--NTKLPFMFTTGEAVLY----------EATNPFPAIMDPLPLRTKNGT 435

  Fly   424 PTRPNRRYKTQLRDFLSTCRSKRKLQQQNQ-------PQTQQTSPLGGQVGSPAPAVAVEYLPDP 481
            ..:.:....|..:|.|:.......:.||::       ..|..|:|......:.:......:..:.
Human   436 SGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAPFENNFFNESMNECRNWQDNT 500

  Fly   482 AAA---VAAAYSNLNPMYTTSPYASAADNLYMGSSMPANAFYPVSENL--------------FHQ 529
            |..   ....:..::.....:.:|.....|:..|.  .:..|.:.:||              |.:
Human   501 APMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSK--NSDLYSIMKNLGIDFEDIRHMQNEKFFR 563

  Fly   530 YRLQGAVGGYYTD-------YPHSGAPASAYVANGFLSYDGYAIASK------------------ 569
            ....|.|.....|       |.......|.::.:.:......|:.|.
Human   564 NDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQQQQSLALNSSCMVQEHLHLEQQQQHHQK 628

  Fly   570 ---ADEKWQETGKYYSGYSSGYGSPTSTPQQIPLKTPKSSPQVMEVISCSSDGPSPVGGATPNGV 631
               .:.:.|...|......:|.....::.|.:|...|:..||...|.:            ..:|:
Human   629 QVVVEPQQQLCQKMKHMQVNGMFENWNSNQFVPFNCPQQDPQQYNVFT------------DLHGI 681

  Fly   632 GSVTP-KVELAGTTAAAAAGQDPYERQTVLMWGTTHSSGVPLNSHGGRTGAGNPASPQRS--TPL 693
            ....| |.|:...         ||.:..:                    ....|..||.|  |.|
Human   682 SQEFPYKSEMDSM---------PYTQNFI--------------------SCNQPVLPQHSKCTEL 717

  Fly   694 GNGLG------YASAN-------------NNNNDLEPATAAKWNGTKELPGKSGSASTPESYQMQ 739
            ...:|      |.:.:             |..:.|.|.:|.       :..::..|.....||.|
Human   718 DYPMGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAI-------ITPQTCYAGAVSMYQCQ 775

  Fly   740 HDDSGLYSASSHTTSPQQQ-------QQQQLQQSQRGVGSNVSAPSSSLTSTGTDQQAVHPSSCH 797
            .:       ..||...|.|       ||..|.:.|.|| .|.:.| :.|.:....|...|
Human   776 PE-------PQHTHVGQMQYNPVLPGQQAFLNKFQNGV-LNETYP-AELNNINNTQTTTH----- 826

  Fly   798 QQQQQQQQQHH--HAHPHP 814
                 .|..||  .|.|.|
Human   827 -----LQPLHHPSEARPFP 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ss	NP_001163629.2	HLH	35..76	CDD:197674	30/40 (75%)
		PAS	123..178	CDD:214512	33/54 (61%)
		PAS_3	282..366	CDD:285623	36/84 (43%)
		PAS	<291..369	CDD:238075	36/78 (46%)
AHR	NP_001612.1	HLH	37..78	CDD:238036	30/40 (75%)
		PAS	113..227	CDD:279347	46/114 (40%)
		PAS	122..224	CDD:238075	40/102 (39%)
		PAS_3	297..382	CDD:285623	36/84 (43%)
		PAS	298..386	CDD:238075	38/87 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147390
Domainoid	1	1.000	88	1.000	Domainoid score	I7944
eggNOG	1	0.900	-	-		E1_KOG3560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004717
OrthoInspector	1	1.000	-	-		oto89502
orthoMCL	1	0.900	-	-		OOG6_107946
Panther	1	1.100	-	-	O	PTHR10649
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5400
SonicParanoid	1	1.000	-	-		X3318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.730