Protein Alignment ss and Ahr

DIOPT Version :10

• Sequence 1: NP_001163629.2
• Gene: ss / 41988
• FlyBaseID: FBgn0003513
• Length: 1015
• Species: Drosophila melanogaster
• Sequence 2: NP_038492.1
• Gene: Ahr / 11622
• MGIID: 105043
• Length: 805
• Species: Mus musculus
• Alignment Length: 962
• Identity: 277/962 - (28%)
• Similarity: 396/962 - (41%)
• Gaps: 312/962 - (32%)

  Fly     8 YATKRRRRN-GKSLKPPPKDGVTKSNPSKRHRERLNAELDLLASLLPFEQNILSKLDRLSILRLS 71
            ||:::||:. .|::||.|.:|: |||||||||:|||.|||.|||||||.|::::|||:||:||||
Mouse     9 YASRKRRKPVQKTVKPIPAEGI-KSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLS 72

  Fly    72 VSYLRTKSYFQVVMHKDKED-NGVLPHIHAHDGYRTRELGAFEHGLLDGDMFLQALNGFLMILTC 135
            |||||.||:|.|.:.....| ||......|    :.|:.    ..|.:|:..|||||||::::|.
Mouse    73 VSYLRAKSFFDVALKSTPADRNGGQDQCRA----QIRDW----QDLQEGEFLLQALNGFVLVVTA 129

  Fly   136 EGEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLW-----------NSFLPADMS 189
            :..||:|:.:|:.||||.|||::|||||||:|:|||.|.||||.|           .:..|...:
Mouse   130 DALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPDSAQGVDEAHGPPQAA 194

  Fly   190 SMQLAETLAPDKALYLERSFTVRFRCLLDNTSGFLRLDIRGRIKVLHGQNRKTEE-----PPLAL 249
            .....:.|.|:.|.::||.|..|.||||||:||||.::.:||:|.|||||:|.::     |.|||
Mouse   195 VYYTPDQLPPENASFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLAL 259

  Fly   250 FAYCTPFGPPSLLEIPHKENMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMG-GYDLVHYDDL 313
            ||..||..|||:|||..|..:|::||||||:.:..|.:|:.||||.:.||...| ||..:|..|:
Mouse   260 FAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCTRGSGYQFIHAADI 324

  Fly   314 AYVASAHQELLKTGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPDFVICTHRQLMDEEGHDLL 378
            .:.|.:|..::|||.|||..:|...|...|:|:|:::||:|:|.:||::|.|.|.|.||||.:.|
Mouse   325 LHCAESHIRMIKTGESGMTVFRLLAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDEEGREHL 389

  Fly   379 GKRTMDFKVSYLDTGLASTYFSEADQLVVPPSTSPTAHALPPPVTPTRPNRRYKTQLRDFLSTCR 443
            .||:......:. ||.|..|          ..:||.:..:.|....|:.|    |..:|:
Mouse   390 QKRSTSLPFMFA-TGEAVLY----------EISSPFSPIMDPLPIRTKSN----TSRKDW----- 434

  Fly   444 SKRKLQQQNQPQTQQTSPLGGQVGSPAPAVAVEYLPDPAAAVAAAYSNLNPMYTTSPYASAADNL 508
                        ..|::|
Mouse   435 ------------APQSTP----------------------------------------------- 440

  Fly   509 YMGSSMPANAFYPVSENLFHQYRLQGAVGGYYTDYPHSGAPASAYVANGFLSYDGYAIASKADEK 573
                          |::.||...|..|:                               .:.||
Mouse   441 --------------SKDSFHPSSLMSAL-------------------------------IQQDE- 459

  Fly   574 WQETGKYYSGYSSGYGSPTSTPQQIPLKTPKSSPQVMEVIS-CSSDGPSPVGGATPNGVGSVTPK 637
                        |.|..|.|:|..:      .|..:|..:| |                ||....
Mouse   460 ------------SIYLCPPSSPALL------DSHFLMGSVSKC----------------GSWQDS 490

  Fly   638 VELAGTTAAAAAGQDPYERQTVLMWGTTHSSGVPLNSHGGRTGAGNPASPQRSTPLGNGLGYASA 702
            ...||:.||....|            ..|:..|.|...||         |....|
Mouse   491 FAAAGSEAALKHEQ------------IGHAQDVNLALSGG---------PSELFP---------- 524

  Fly   703 NNNNNDLEPATAAKWNGTKELPGKSGSASTPESYQMQHDDSGLYSASSHTTSPQQQQQQQLQQSQ 767
            :|.||||                    .|...:..:..:|.            :..|.::..::.
Mouse   525 DNKNNDL--------------------YSIMRNLGIDFEDI------------RSMQNEEFFRTD 557

  Fly   768 RGVGSNV-----------------SAPSSSLTSTGTDQQAV--HPSSCHQQQQQQQQQHHHAHPH 813
            ......|                 |..:|:|.::...||.|  |.|...|::.|.:||.....|.
Mouse   558 STAAGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPVTQHLSCMLQERLQLEQQQQLQQPP 622

  Fly   814 PHSHHHHHHHHHHETAHQHSSEIILTTHHQQQSQQQ---QQSLAGYPLHHQLVGVGSGSPPPQPP 875
            |.:                       ...|||..|.   ||.|.  |.|.|:.|. ..|..|.||
Mouse   623 PQA-----------------------LEPQQQLCQMVCPQQDLG--PKHTQINGT-FASWNPTPP 661

  Fly   876 VALSRSPTTLPAVSSLLNGSASAGGASDIPY----------QQLAIVSAPLV 917
            |:.:.....|......   |:..|.|.:.||          |..|..:.||:
Mouse   662 VSFNCPQQELKHYQLF---SSLQGTAQEFPYKPEVDSVPYTQNFAPCNQPLL 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ss	NP_001163629.2	bHLH-PAS_spineless_like	24..87	CDD:381573	43/62 (69%)
		PAS	123..178	CDD:214512	33/54 (61%)
		PAS_3	282..366	CDD:430001	33/84 (39%)
Ahr	NP_038492.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		15/29 (52%)
		Nuclear localization signal 1. /evidence=ECO:0000250|UniProtKB:P35869	12..15		0/2 (0%)
		bHLH-PAS_AhR	27..87	CDD:381442	42/60 (70%)
		Nuclear localization signal 2. /evidence=ECO:0000250|UniProtKB:P35869	36..41		4/4 (100%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P35869	37..65		19/27 (70%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P35869	49..81		23/31 (74%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:P35869	63..71		5/7 (71%)
		PAS	111..>177	CDD:395786	37/65 (57%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561	116..124		6/7 (86%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561	260..262		1/1 (100%)
		PAS_3	291..376	CDD:430001	33/84 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..449		9/109 (8%)