DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ss and Ahr

DIOPT Version :9

Sequence 1:NP_001163629.2 Gene:ss / 41988 FlyBaseID:FBgn0003513 Length:1015 Species:Drosophila melanogaster
Sequence 2:NP_038492.1 Gene:Ahr / 11622 MGIID:105043 Length:805 Species:Mus musculus


Alignment Length:962 Identity:277/962 - (28%)
Similarity:396/962 - (41%) Gaps:312/962 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 YATKRRRRN-GKSLKPPPKDGVTKSNPSKRHRERLNAELDLLASLLPFEQNILSKLDRLSILRLS 71
            ||:::||:. .|::||.|.:|: |||||||||:|||.|||.|||||||.|::::|||:||:||||
Mouse     9 YASRKRRKPVQKTVKPIPAEGI-KSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLS 72

  Fly    72 VSYLRTKSYFQVVMHKDKED-NGVLPHIHAHDGYRTRELGAFEHGLLDGDMFLQALNGFLMILTC 135
            |||||.||:|.|.:.....| ||......|    :.|:.    ..|.:|:..|||||||::::|.
Mouse    73 VSYLRAKSFFDVALKSTPADRNGGQDQCRA----QIRDW----QDLQEGEFLLQALNGFVLVVTA 129

  Fly   136 EGEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLW-----------NSFLPADMS 189
            :..||:|:.:|:.||||.|||::|||||||:|:|||.|.||||.|           .:..|...:
Mouse   130 DALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPDSAQGVDEAHGPPQAA 194

  Fly   190 SMQLAETLAPDKALYLERSFTVRFRCLLDNTSGFLRLDIRGRIKVLHGQNRKTEE-----PPLAL 249
            .....:.|.|:.|.::||.|..|.||||||:||||.::.:||:|.|||||:|.::     |.|||
Mouse   195 VYYTPDQLPPENASFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLAL 259

  Fly   250 FAYCTPFGPPSLLEIPHKENMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMG-GYDLVHYDDL 313
            ||..||..|||:|||..|..:|::||||||:.:..|.:|:.||||.:.||...| ||..:|..|:
Mouse   260 FAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCTRGSGYQFIHAADI 324

  Fly   314 AYVASAHQELLKTGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPDFVICTHRQLMDEEGHDLL 378
            .:.|.:|..::|||.|||..:|...|...|:|:|:::||:|:|.:||::|.|.|.|.||||.:.|
Mouse   325 LHCAESHIRMIKTGESGMTVFRLLAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDEEGREHL 389

  Fly   379 GKRTMDFKVSYLDTGLASTYFSEADQLVVPPSTSPTAHALPPPVTPTRPNRRYKTQLRDFLSTCR 443
            .||:......:. ||.|..|          ..:||.:..:.|....|:.|    |..:|:     
Mouse   390 QKRSTSLPFMFA-TGEAVLY----------EISSPFSPIMDPLPIRTKSN----TSRKDW----- 434

  Fly   444 SKRKLQQQNQPQTQQTSPLGGQVGSPAPAVAVEYLPDPAAAVAAAYSNLNPMYTTSPYASAADNL 508
                        ..|::|                                               
Mouse   435 ------------APQSTP----------------------------------------------- 440

  Fly   509 YMGSSMPANAFYPVSENLFHQYRLQGAVGGYYTDYPHSGAPASAYVANGFLSYDGYAIASKADEK 573
                          |::.||...|..|:                               .:.|| 
Mouse   441 --------------SKDSFHPSSLMSAL-------------------------------IQQDE- 459

  Fly   574 WQETGKYYSGYSSGYGSPTSTPQQIPLKTPKSSPQVMEVIS-CSSDGPSPVGGATPNGVGSVTPK 637
                        |.|..|.|:|..:      .|..:|..:| |                ||....
Mouse   460 ------------SIYLCPPSSPALL------DSHFLMGSVSKC----------------GSWQDS 490

  Fly   638 VELAGTTAAAAAGQDPYERQTVLMWGTTHSSGVPLNSHGGRTGAGNPASPQRSTPLGNGLGYASA 702
            ...||:.||....|            ..|:..|.|...||         |....|          
Mouse   491 FAAAGSEAALKHEQ------------IGHAQDVNLALSGG---------PSELFP---------- 524

  Fly   703 NNNNNDLEPATAAKWNGTKELPGKSGSASTPESYQMQHDDSGLYSASSHTTSPQQQQQQQLQQSQ 767
            :|.||||                    .|...:..:..:|.            :..|.::..::.
Mouse   525 DNKNNDL--------------------YSIMRNLGIDFEDI------------RSMQNEEFFRTD 557

  Fly   768 RGVGSNV-----------------SAPSSSLTSTGTDQQAV--HPSSCHQQQQQQQQQHHHAHPH 813
            ......|                 |..:|:|.::...||.|  |.|...|::.|.:||.....|.
Mouse   558 STAAGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPVTQHLSCMLQERLQLEQQQQLQQPP 622

  Fly   814 PHSHHHHHHHHHHETAHQHSSEIILTTHHQQQSQQQ---QQSLAGYPLHHQLVGVGSGSPPPQPP 875
            |.:                       ...|||..|.   ||.|.  |.|.|:.|. ..|..|.||
Mouse   623 PQA-----------------------LEPQQQLCQMVCPQQDLG--PKHTQINGT-FASWNPTPP 661

  Fly   876 VALSRSPTTLPAVSSLLNGSASAGGASDIPY----------QQLAIVSAPLV 917
            |:.:.....|......   |:..|.|.:.||          |..|..:.||:
Mouse   662 VSFNCPQQELKHYQLF---SSLQGTAQEFPYKPEVDSVPYTQNFAPCNQPLL 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ssNP_001163629.2 HLH 35..76 CDD:197674 30/40 (75%)
PAS 123..178 CDD:214512 33/54 (61%)
PAS_3 282..366 CDD:285623 33/84 (39%)
PAS <291..369 CDD:238075 33/78 (42%)
AhrNP_038492.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38 15/29 (52%)
HLH 36..77 CDD:238036 30/40 (75%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:P35869 37..65 19/27 (70%)
PAS 111..177 CDD:214512 37/65 (57%)
PAS 111..>177 CDD:279347 37/65 (57%)
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000269|PubMed:24001774 116..124 6/7 (86%)
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000269|PubMed:24001774 260..262 1/1 (100%)
PAS 276..380 CDD:238075 43/103 (42%)
PAS_3 291..376 CDD:285623 33/84 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 421..449 9/109 (8%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837322
Domainoid 1 1.000 100 1.000 Domainoid score I7016
eggNOG 1 0.900 - - E1_KOG3560
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004717
OrthoInspector 1 1.000 - - oto93073
orthoMCL 1 0.900 - - OOG6_107946
Panther 1 1.100 - - O PTHR10649
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5400
SonicParanoid 1 1.000 - - X3318
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.730

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