Protein Alignment Manf and Manf

DIOPT Version :10

• Sequence 1: NP_477445.1
• Gene: Manf / 41983
• FlyBaseID: FBgn0027095
• Length: 173
• Species: Drosophila melanogaster
• Sequence 2: NP_083379.2
• Gene: Manf / 74840
• MGIID: 1922090
• Length: 179
• Species: Mus musculus
• Alignment Length: 166
• Identity: 84/166 - (50%)
• Similarity: 117/166 - (70%)
• Gaps: 7/166 - (4%)

  Fly     8 VVIGFLATLAQTSLALKEEDCEVCVKTVRRFADSLDDSTKKDY----KQIETAFKKFCKAQKNKE 68
            :.:....::...|.||:..|||||:..:.||...|.|   :|.    ..||....|||:..:.||
Mouse     7 LAVALALSVLPDSRALRPGDCEVCISYLGRFYQDLKD---RDVTFSPATIEEELIKFCREARGKE 68

  Fly    69 HRFCYYLGGLEESATGILNELSKPLSWSMPAEKICEKLKKKDAQICDLRYEKQIDLNSVDLKKLK 133
            :|.|||:|..:::||.|:||:||||:..:|.|||||||||||:|||:|:|:|||||::||||||:
Mouse    69 NRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKLR 133

  Fly   134 VRDLKKILNDWDESCDGCLEKGDFIKRIEELKPKYS 169
            |::|||||:||.|.|.||.||.|:|::|.||.|||:
Mouse   134 VKELKKILDDWGEMCKGCAEKSDYIRKINELMPKYA 169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Manf	NP_477445.1	ARMET_N	27..122	CDD:466306	49/98 (50%)
		ARMET_C	126..168	CDD:462997	26/41 (63%)
Manf	NP_083379.2	ARMET_N	26..122	CDD:466306	50/99 (51%)
		Interacts with ERN1, EIF2AK3 and ATF6. /evidence=ECO:0000250|UniProtKB:P55145	93..155		42/61 (69%)
		Interacts with HSPA5. /evidence=ECO:0000269|PubMed:30710085	126..169		28/43 (65%)
		ARMET_C	126..168	CDD:462997	27/41 (66%)