DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pad and AZF1

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_014756.3	Gene:	AZF1 / 854280	SGDID:	S000005639	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	966	Identity:	195/966 - (20%)
Similarity:	317/966 - (32%)	Gaps:	272/966 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 ETGKSLSVAQSAPPVPNGAQQSGN----LLNSIIQAVNMQPQQQYTITMDNGVQQQQQQHQAMPE 170
            :.|::.|..||:.......|:.|.    :||. .|..:.||            |.|||:::::..
Yeast    13 QAGQNESQNQSSGEAGEQNQEHGQGPTPILNQ-SQPASSQP------------QHQQQRNESISY 64

  Fly   171 V----QIKSERQTALEEFIRLKPDIKITPLGKKEPISPAKPQQQHSLQSQTVTPTINPTQLQLQP 231
            .    |.:.....::..|:.:..::.:|..|     .|:......:|...:.:.|..|..|.
Yeast    65 YTNFNQPRYSTDASINSFLNISDNVPVTSTG-----GPSSGGAYSNLPRLSTSSTHQPPDLS--- 121

  Fly   232 QLG------DQLQPLWQQIQQLQLQQQLQQLTNQLQ---------------ATTQYS-VAQDDTS 274
            |:|      :.|.|..||:|....|||.||.....|               :::||. :.::|.:
Yeast   122 QIGRGFSIVNNLFPQQQQLQNQHRQQQQQQQQQSHQQPPFKTPSFSTGLTGSSSQYQFLPRNDNT 186

  Fly   275 SSGDSKKPKLNFVLSSPT-APQFT-TSMPQFGGSQPQIQLQLMPGSGGVTSAGTVPAQTQLNAAA 337
            |...||:   |.|...|. .|.|. .||.|  ..|||.|......|..:.....:||.|..:.
Yeast   187 SQPPSKR---NSVYLGPNDGPDFEFFSMQQ--SQQPQFQPSSRRESNSMRPPLLIPAATTKSQ-- 244

  Fly   338 LLSSLAGPQSTTNLLSPNKCFLPITIRDENSDQQIVAHIDTKNLVL---PTTYQVQMKLQPQL-- 397
              |:........|..:..:.|......:.||:|. ...:.::|..|   |..:..|.|.:...
Yeast   245 --SNGTNNSGNMNTNADYESFFNTGTNNSNSNQN-PYFLSSRNNSLKFNPEDFDFQFKRRNSFVR 306

  Fly   398 ATADGQPIMQLTPTSIPATLQLTPQTLGNPGSAFQGTTVTQNQFLAPQQPLTQLPNTAQVTSQQI 462
            .|.|........|.|...:|.:..:..|:|        |..|           :.|..:..|.::
Yeast   307 GTLDHSSQNAFIPESRLNSLSVNNKANGDP--------VADN-----------VTNNMKGKSNEV 352

  Fly   463 IRSPHTSTTNSQLVIRN-----------------------VTNIP--------PTPTTPTSSKKA 496
            .......::|:.....|                       .||||        .|.||..|.|..
Yeast   353 DNDDGNDSSNNNNNNNNNNNNENNNDNNNDNNDNSINSATSTNIPNQEDHSLASTDTTSNSRKDL 417

  Fly   497 PTFKTPSPK--------QKPMPSPKSKTTVGPSSGGSNGTSTNEFKRLITQTKPQPQV----KQQ 549
            ...:....|        ...:..|..|..|...|.|.|        :.|.::..||.:    |:.
Yeast   418 KEIEQRLRKHLNDEDNYSSAISRPLDKNDVIEGSEGLN--------KHIDESGMQPNIIKKRKKD 474

  Fly   550 QTAGLSASGAP---------TATSANQAAMQRLSSNTTITKVPKQPASLPAPAPTSNPAKLPMLN 605
            .:.....:..|         .:|||..|||...|.        |:|     |.|
Yeast   475 DSTVYVKNEMPRTDPPMSKDNSTSAEGAAMANFSG--------KEP-----PIP----------- 515

  Fly   606 KQNITISRISMQTAPKAQSKPSTTSPTPASQPIPVSVPALSQAQPPPLAAQHKKIVRKPPENQDT 670
                .||.:|       ....:....|...|.:.:            :.|:.|....|....||.
Yeast   516 ----DISSVS-------DDATNLIGATKVDQLMLI------------IQARKKGFTEKVNTTQDG 557

  Fly   671 S---GQKVKAARPPQQILPSPQQ-EGQNATHSGSEAPTTSGLICPTCKREFKKKEHLTQHVKLHA 731
            .   .|.:....|..:::...:: :|...|.:..:..      ||.|.|.|.:..||..||:.|.
Yeast   558 DLLFNQTMDILPPKSELVGGVEKPKGTQNTRAVKKHE------CPYCHRLFSQATHLEVHVRSHI 616

  Fly   732 GLRPFKCSEEGCDKTFSRKEHLSRHLVSHSGQKMYTCEVCKKPFSRKDNLNKHRRIHTQTSTETL 796
            |.:||.|  :.|.|.|::..:|..|...|:|:|.|:|::|.|.||||.||..|...|.:...
Yeast   617 GYKPFVC--DYCGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAHLVTHQKLKP--- 676

  Fly   797 YCCDV--CNKNFATKLHYEKHR-EMHK-----------KIRPESAAP------------------ 829
            :.|.:  |||.|....:.:.|: ..||           ::.|....|
Yeast   677 FVCKLENCNKTFTQLGNMKAHQNRFHKETLNALTAKLAEMNPSENIPLEERQLLEYFASIYKNSN 741

  Fly   830 --------------GATASPAAAPALT----HVRSNGQVPNKAVFEIKQERSAQQTQTQQPPAQV 876
                          ...:||...||.|    :..:|..:.|.:......|.:...:....|.:..
Yeast   742 RGIKGRGKGVGTKKSTISSPENHPASTILNPNTNANNAIANDSENNGNPEGNIDSSSNSNPGSHS 806

  Fly   877 MHVVTTQDLAGNTI-----------TITQAPDSNMPGSLANYVQLGFSQFQNPSAS 921
            |...|.:|:  .|:           ::..:..||.|....||..|..|:..:.|:|
Yeast   807 MISPTQKDM--GTLQSQFIQNNFNNSVNSSNPSNQPIINYNYTTLPHSRLGSSSSS 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871
		C2H2 Zn finger	710..730	CDD:275368	9/19 (47%)
		zf-C2H2	736..760	CDD:278523	7/23 (30%)
		C2H2 Zn finger	738..760	CDD:275368	6/21 (29%)
		zf-H2C2_2	752..777	CDD:290200	10/24 (42%)
		zf-C2H2	766..788	CDD:278523	11/21 (52%)
		C2H2 Zn finger	768..788	CDD:275368	10/19 (53%)
		zf-H2C2_2	780..808	CDD:290200	9/29 (31%)
		C2H2 Zn finger	799..819	CDD:275368	6/22 (27%)
AZF1	NP_014756.3	COG5048	342..768	CDD:227381	98/491 (20%)
		C2H2 Zn finger	595..615	CDD:275368	9/19 (47%)
		C2H2 Zn finger	623..643	CDD:275368	6/21 (29%)
		C2H2 Zn finger	651..671	CDD:275368	10/19 (53%)
		C2H2 Zn finger	679..702	CDD:275368	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910