DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pad and ZSCAN10

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_116194.2	Gene:	ZSCAN10 / 84891	HGNCID:	12997	Length:	780	Species:	Homo sapiens

Alignment Length:	743	Identity:	150/743 - (20%)
Similarity:	251/743 - (33%)	Gaps:	216/743 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 LGKKEPISPAKPQQQHSLQSQTVTPTINPTQLQLQPQLGDQLQPLWQQIQQLQLQQQLQQLTNQL 260
            |.::|.:||..|::..|               :|:|::..||...:|..:.:..:..|.:|
Human    20 LEEEEAVSPEDPRRPES---------------RLRPEVAHQLFRCFQYQEDMGPRASLSRL---- 65

  Fly   261 QATTQYSVAQDDTSSSGDSKKPKLNF---VLSSPTAPQFTTSMPQFGGSQPQI--QLQLMPGSGG 320
                        ....|...:|.|:.   :|......||.:.:|      |.:  :||..|...|
Human    66 ------------RELCGHWLRPALHTKKQILELLVLEQFLSVLP------PHLLGRLQGQPLRDG 112

  Fly   321 VTSAGTVPAQTQLNAAALLSSL------AGPQSTTNLLSPNKCFLPITIRDENSDQQIVAHIDTK 379
            .            ....||..:      |||...:.....:.....:|:.::....|:.:|...|
Human   113 E------------EVVLLLEGIHREPSHAGPLDFSCNAGKSCPRADVTLEEKGCASQVPSHSPKK 165

  Fly   380 NLVLPTTYQVQMKLQPQLATADGQPIMQLTPTSIPATLQLTPQTLGNPGSAFQGTTVTQNQFLAP 444
            .  ||..       :|.:          |.|:..|...|........||           |:..|
Human   166 E--LPAE-------EPSV----------LGPSDEPPRPQPRAAQPAEPG-----------QWRLP 200

  Fly   445 ---QQPLTQLPNTAQVTSQQIIRSPHTSTTNSQLVIRNVTNIPPTPTTPTSSK--------KAPT 498
               :|||:..|   |.|.|.:..|....               |:|....||:        :..|
Human   201 PSSKQPLSPGP---QKTFQALQESSPQG---------------PSPWPEESSRDQELAAVLECLT 247

  Fly   499 FKTPSPKQKPMPSPKSKTTVGPSSGGSNGTSTNEFKRLITQTK----PQPQVKQQQTAGLSASGA 559
            |: ..|:.|..|:       .|...||......|||:  .:.|    |.|.:.:.|.......|.
Human   248 FE-DVPENKAWPA-------HPLGFGSRTPDKEEFKQ--EEPKGAAWPTPILAESQADSPGVPGE 302

  Fly   560 PTATSANQAAMQ-------RLSSNTTITKVPKQPASLPAPAPTSNPAKLPMLNKQNITISRISMQ 617
            |.|.|..:.|..       .|..::.|.:| |....:|.|    ||....:.....::..::|..
Human   303 PCAQSLGRGAAASGPGEDGSLLGSSEILEV-KVAEGVPEP----NPELQFICADCGVSFPQLSRL 362

  Fly   618 TAPKAQSKP-------------------------STTSPTPAS---------QPIPVSVPALSQA 648
            .|.:.:|.|                         :.|...|.:         |...:|...|:.:
Human   363 KAHQLRSHPAGRSFLCLCCGKSFGRSSILKLHMRTHTDERPHACHLCGHRFRQSSHLSKHLLTHS 427

  Fly   649 QPPP-LAAQHKKIVRKPPENQDTSGQKVKAARPPQQILPSPQQEGQNATHSGSEAPTTSGLICPT 712
            ..|. |.|:..:            |.:.:|:.....:..:..|:...|..|.:|||..:.::|..
Human   428 SEPAFLCAECGR------------GFQRRASLVQHLLAHAQDQKPPCAPESKAEAPPLTDVLCSH 480

  Fly   713 CKREFKKKEHLTQHVKLHA------------------GLRPFKCSEEGCDKTFSRKEHLSRHLVS 759
            |.:.|:::..|.:|:::||                  ..|||.||:  |.|.|.|.|||..|...
Human   481 CGQSFQRRSSLKRHLRIHARDKDRRSSEGSGSRRRDSDRRPFVCSD--CGKAFRRSEHLVAHRRV 543

  Fly   760 HSGQKMYTCEVCKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFATKLHYEKHREMHKKIRP 824
            |:|::.::|:.|.:.|::...|..|:|:||   .|..|.|..|.|.|..:....:|...|...||
Human   544 HTGERPFSCQACGRSFTQSSQLVSHQRVHT---GEKPYACPQCGKRFVRRASLARHLLTHGGPRP 605

  Fly   825 ESAAPGATASPAAAPALTHVRSN-GQVP 851
            ........:.........|.||: |:.|
Human   606 HHCTQCGKSFGQTQDLARHQRSHTGEKP 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871
		C2H2 Zn finger	710..730	CDD:275368	5/19 (26%)
		zf-C2H2	736..760	CDD:278523	11/23 (48%)
		C2H2 Zn finger	738..760	CDD:275368	10/21 (48%)
		zf-H2C2_2	752..777	CDD:290200	8/24 (33%)
		zf-C2H2	766..788	CDD:278523	6/21 (29%)
		C2H2 Zn finger	768..788	CDD:275368	6/19 (32%)
		zf-H2C2_2	780..808	CDD:290200	11/27 (41%)
		C2H2 Zn finger	799..819	CDD:275368	5/19 (26%)
ZSCAN10	NP_116194.2	SCAN	40..124	CDD:153421	20/117 (17%)
		PHA03418	156..>314	CDD:177646	46/215 (21%)
		C2H2 Zn finger	349..370	CDD:275368	2/20 (10%)
		C2H2 Zn finger	378..398	CDD:275368	0/19 (0%)
		zf-H2C2_2	391..415	CDD:290200	2/23 (9%)
		COG5048	400..774	CDD:227381	60/251 (24%)
		C2H2 Zn finger	406..426	CDD:275368	3/19 (16%)
		C2H2 Zn finger	434..454	CDD:275368	3/31 (10%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		zf-C2H2	522..544	CDD:278523	11/23 (48%)
		C2H2 Zn finger	524..544	CDD:275368	10/21 (48%)
		zf-H2C2_2	536..561	CDD:290200	8/24 (33%)
		C2H2 Zn finger	552..572	CDD:275368	6/19 (32%)
		zf-H2C2_2	565..589	CDD:290200	11/26 (42%)
		C2H2 Zn finger	580..600	CDD:275368	5/19 (26%)
		zf-H2C2_2	592..615	CDD:290200	4/22 (18%)
		C2H2 Zn finger	608..628	CDD:275368	2/19 (11%)
		zf-H2C2_2	620..645	CDD:290200	5/14 (36%)
		C2H2 Zn finger	636..656	CDD:275368
		zf-H2C2_2	648..673	CDD:290200
		C2H2 Zn finger	664..684	CDD:275368
		zf-H2C2_2	676..701	CDD:290200
		C2H2 Zn finger	692..712	CDD:275368
		C2H2 Zn finger	728..746	CDD:275368
		zf-H2C2_2	738..763	CDD:290200
		zf-C2H2	752..774	CDD:278523
		C2H2 Zn finger	754..774	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010