DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pad and SP1

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_612482.2	Gene:	SP1 / 6667	HGNCID:	11205	Length:	785	Species:	Homo sapiens

Alignment Length:	926	Identity:	210/926 - (22%)
Similarity:	306/926 - (33%)	Gaps:	303/926 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LRATCRNSQTMLNNCLNIR-PAPSSDKLYIRDAVDETGKSLS--------VAQSAPPVPNGAQQS 131
            |.|||...::...|..|.: |:.|..    ...:|.|...||        ::.|:...|...:||
Human    64 LAATCSRIESPNENSNNSQGPSQSGG----TGELDLTATQLSQGANGWQIISSSSGATPTSKEQS 124

  Fly   132 GNLLNS------------------IIQAVNMQPQQQYTITMDNGVQQQQQQHQAMPEVQIKSERQ 178
            |:..|.                  :..|.|:|.||  .:|...|| ....|:|.:|:.|....:|
Human   125 GSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQ--VLTGLPGV-MPNIQYQVIPQFQTVDGQQ 186

  Fly   179 TALEEFIRLKPDIKITPLGKKEPISPAKPQQQHSLQSQTVTPTINPTQLQLQPQLGDQLQPLWQQ 243
                        ::....|       |:.||..|.|.| :.|..|...:..:...|:.:..:...
Human   187 ------------LQFAATG-------AQVQQDGSGQIQ-IIPGANQQIITNRGSGGNIIAAMPNL 231

  Fly   244 IQQLQLQQQLQQLTNQ-LQATTQYSVAQDDTSSSGDSKKPKLNFVLSSPTAPQ-----FTTSMPQ 302
            :||   ...||.|.|. |...||| |.....:.:|:.....:|.|.::...|.     .::|..|
Human   232 LQQ---AVPLQGLANNVLSGQTQY-VTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQ 292

  Fly   303 FGGSQPQIQLQLMPGSGGVTSAGTVPAQTQLNAAALLSSLAGPQS-TTNLLSPNKCFLPITIRDE 366
            ..||||            |||.      |.:::|:|:||.|...| .||
Human   293 ESGSQP------------VTSG------TTISSASLVSSQASSSSFFTN---------------- 323

  Fly   367 NSDQQIVAHIDTKNLVLPTTYQVQMKLQPQLATADGQPIMQLTPTSIPATLQ--LTPQTLGNPGS 429
                        .|....||            |.....||..|.:....|..  .|||.:    |
Human   324 ------------ANSYSTTT------------TTSNMGIMNFTTSGSSGTNSQGQTPQRV----S 360

  Fly   430 AFQGT---TVTQNQ-----FLAPQQPLTQLPNTAQVTSQQIIRSPHTSTTNSQLVIRNVTNIPPT 486
            ..||:   .:.|||     ..|.||  .:.....|...|||:..|.        :::....:...
Human   361 GLQGSDALNIQQNQTSGGSLQAGQQ--KEGEQNQQTQQQQILIQPQ--------LVQGGQALQAL 415

  Fly   487 PTTPTSSKKAPTFKTPSPKQKPMPS------PKS------KTTVGPSSGGSNGTSTNEFKRLITQ 539
            ...|.|.:   ||.|.:..|:.:.:      |.|      ..||||:  |.....|.:.:.|
Human   416 QAAPLSGQ---TFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPN--GQVSWQTLQLQNL--- 472

  Fly   540 TKPQPQVKQQQTAGLSASGAP-TATSANQAAMQRLSSNTTITKVPKQPASLPAPAPTSNPAKLPM 603
               |.|..|.||..|    || ...|..|.:    |||||:|.: ...||:||...|.|.|:|
Human   473 ---QVQNPQAQTITL----APMQGVSLGQTS----SSNTTLTPI-ASAASIPAGTVTVNAAQL-- 523

  Fly   604 LNKQNITISRISMQTAPKAQSKPSTTSPTPASQPIPVSVPALSQAQPPPLAAQHKKIVRKPPE-- 666
                                      |..|..|.|.:|....|..|..|:......|...|.:
Human   524 --------------------------SSMPGLQTINLSALGTSGIQVHPIQGLPLAIANAPGDHG 562

  Fly   667 -------------NQDTSGQKVKAARPPQQILPSPQQEGQNATHSGSEA---PTTSGLICPTCKR 715
                         :.||:|                .:||:|:..:..:|   .......||.||.
Human   563 AQLGLHGAGGDGIHDDTAG----------------GEEGENSPDAQPQAGRRTRREACTCPYCKD 611

  Fly   716 E--------FKKKEHLTQHVKLHAGLRPFKCSEEGCDKTFSRKEHLSRHLVSHSGQKMYTC--EV 770
            .        .|||:|:              |..:||.|.:.:..||..||..|:|::.:.|  ..
Human   612 SEGRGSGDPGKKKQHI--------------CHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSY 662

  Fly   771 CKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFATKLHYEKHREMHKKIRPESAAPGATASP 835
            |.|.|:|.|.|.:|:|.||   .|..:.|..|.|.|....|..||.:.|:.   :...||...|.
Human   663 CGKRFTRSDELQRHKRTHT---GEKKFACPECPKRFMRSDHLSKHIKTHQN---KKGGPGVALSV 721

  Fly   836 AAAPALTHVRSNGQVPNKAVFEIKQERSAQQTQTQQPPAQVMHVVTTQDLAGNTITITQAPDSNM 900
            ...|..:...|.|                  :.|..|.|    ::||..:|...|         .
Human   722 GTLPLDSGAGSEG------------------SGTATPSA----LITTNMVAMEAI---------C 755

  Fly   901 PGSLANYVQLGFSQFQ 916
            |..:|.....|.:..|
Human   756 PEGIARLANSGINVMQ 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871	4/10 (40%)
		C2H2 Zn finger	710..730	CDD:275368	8/27 (30%)
		zf-C2H2	736..760	CDD:278523	8/23 (35%)
		C2H2 Zn finger	738..760	CDD:275368	8/21 (38%)
		zf-H2C2_2	752..777	CDD:290200	10/26 (38%)
		zf-C2H2	766..788	CDD:278523	9/23 (39%)
		C2H2 Zn finger	768..788	CDD:275368	9/21 (43%)
		zf-H2C2_2	780..808	CDD:290200	10/27 (37%)
		C2H2 Zn finger	799..819	CDD:275368	7/19 (37%)
SP1	NP_612482.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		8/32 (25%)
		Repressor domain	2..82		6/17 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..141		6/31 (19%)
		Transactivation domain A (Gln-rich)	146..251		30/130 (23%)
		Transactivation domain B (Gln-rich)	261..495		71/320 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..395		20/83 (24%)
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	462..470		1/7 (14%)
		Transactivation domain C (highly charged)	496..610		33/162 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..598		7/46 (15%)
		VZV IE62-binding	619..785		51/204 (25%)
		C2H2 Zn finger	628..650	CDD:275368	8/21 (38%)
		zf-H2C2_2	642..669	CDD:290200	10/26 (38%)
		C2H2 Zn finger	658..680	CDD:275368	9/21 (43%)
		zf-H2C2_2	672..695	CDD:290200	9/25 (36%)
		zf-C2H2	686..708	CDD:278523	7/21 (33%)
		C2H2 Zn finger	688..708	CDD:275368	7/19 (37%)
		Domain D	708..785		18/98 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151672
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840