DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pad and egr3

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001002647.1	Gene:	egr3 / 436920	ZFINID:	ZDB-GENE-040718-394	Length:	422	Species:	Danio rerio

Alignment Length:	356	Identity:	89/356 - (25%)
Similarity:	143/356 - (40%)	Gaps:	85/356 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 PSPKSKTTVGPSSGGSNGTSTNEFKRLITQTKPQPQVKQQQTAGLSASGAPTATSANQAAMQRLS 574
            |||.:.||...||.||.|..:::.:::..     |.:....|.|                 :...
Zfish   124 PSPGNITTQTSSSSGSMGGQSSDMEQVYA-----PPLPAYSTCG-----------------EIYP 166

  Fly   575 SNTTITKVPKQPASLPAPA----PTSNP----AKLPMLNKQNITISRISMQTAPKAQSKPSTTSP 631
            ...|....|...:|||.|:    .||.|    :...|:...|:...:..:..   .:.||..|
Zfish   167 EQVTFHHSPATSSSLPYPSSDYHTTSKPGMDGSLFSMIPDYNLFHHQGDVGV---MEHKPFQT-- 226

  Fly   632 TPASQPIPVSVPALSQAQPPPLAAQHKKIVRKPPENQDTSGQKVKAARPPQQILPSPQQEGQNAT 696
               ..||.|:        |||:                |..:.::|.:..|||.|......|:.
Zfish   227 ---MDPIRVN--------PPPI----------------TPLETIRAFKDKQQIHPGFLGGQQHV- 263

  Fly   697 HSGSEAPTTSGLICPTCKREFKKKEHLTQHVKLHAGLRPFKCSEEGCDKTFSRKEHLSRHLVSHS 761
             |....|:.:..:.|...|::..:...|   .:|.  ||..|..|.||:.|||.:.|:|||..|:
Zfish   264 -SQHHQPSQTLALKPIRPRKYPNRPSKT---PVHE--RPHACPAENCDRRFSRSDELTRHLRIHT 322

  Fly   762 GQKMYTCEVCKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFATKLHYEKHREMH-----KK 821
            |.|.:.|.:|.:.|||.|:|..|.|.||   .|..:.|:.|.:.||.....::|.::|     ||
Zfish   323 GHKPFQCRICMRSFSRSDHLTTHIRTHT---GEKPFSCEFCGRKFARSDERKRHAKVHLKQKDKK 384

  Fly   822 IRPESAAPGA----TASP----AAAPALTHV 844
            ...:.::.||    |:.|    :|.|:.|::
Zfish   385 PTDKGSSAGAGGNHTSPPSSCGSAGPSSTNI 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871
		C2H2 Zn finger	710..730	CDD:275368	3/19 (16%)
		zf-C2H2	736..760	CDD:278523	11/23 (48%)
		C2H2 Zn finger	738..760	CDD:275368	11/21 (52%)
		zf-H2C2_2	752..777	CDD:290200	10/24 (42%)
		zf-C2H2	766..788	CDD:278523	9/21 (43%)
		C2H2 Zn finger	768..788	CDD:275368	9/19 (47%)
		zf-H2C2_2	780..808	CDD:290200	9/27 (33%)
		C2H2 Zn finger	799..819	CDD:275368	5/19 (26%)
egr3	NP_001002647.1	DUF3446	88..158	CDD:288757	11/38 (29%)
		C2H2 Zn finger	299..321	CDD:275368	11/21 (52%)
		zf-H2C2_2	313..338	CDD:290200	10/24 (42%)
		COG5048	325..>405	CDD:227381	25/82 (30%)
		C2H2 Zn finger	329..349	CDD:275368	9/19 (47%)
		zf-H2C2_2	341..366	CDD:290200	9/27 (33%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000