DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pad and Phs

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_648789.3	Gene:	Phs / 39697	FlyBaseID:	FBgn0036522	Length:	971	Species:	Drosophila melanogaster

Alignment Length:	980	Identity:	192/980 - (19%)
Similarity:	318/980 - (32%)	Gaps:	355/980 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LSVAQSAPPV-----PNGAQQSGNLLNSIIQAVNMQPQQQYTITMDNGVQQQQQQHQAMPEV--Q 172
            :::|..|.|:     .||.::|        ...:|:.:::         .::.::...:|:|  |
  Fly     4 MAMANGANPLQTMKKANGDEES--------DESDMEEEEE---------DEEDEEEDDLPDVALQ 51

  Fly   173 IKSERQTALE-EFIRLKPD--IKITPLGKKEPISPAKPQQQHSLQSQTVTPTINPTQLQLQPQLG 234
            |.||.:..|| :.|||..:  .|.|...:||.
  Fly    52 IDSEDEAELEAQRIRLVEEEAAKTTKKAEKER--------------------------------- 83

  Fly   235 DQLQPLWQQIQQLQLQQQLQ-QLTN----QLQATTQYSVAQDDTSSSGDSKKPKLNFVLSSPTAP 294
                      ||||.:||.| |::|    ||:.|.:         .|.:.:|.:
  Fly    84 ----------QQLQQKQQRQAQVSNGNEEQLEETQK---------PSNNKRKAR----------- 118

  Fly   295 QFTTSMPQFGGSQPQIQLQLMPGSGGVTSAGT-VPAQTQLNAAALLSSLAGPQSTTNLLSPNKCF 358
                     |..:.:|.......|..:.|:.| |.||.          ||..:|...:.|...|
  Fly   119 ---------GRPKRKISTSSQASSASIASSATLVAAQV----------LADQKSRRFIYSCTSC- 163

  Fly   359 LPITIRDENSDQQIVAHIDTKNLVLPTTYQVQ-----MKLQPQLATADGQPIMQLTPTSIPATL- 417
                          ..|.| .||:|...:|::     .:.:.:...|..:|:  :||..|...|
  Fly   164 --------------THHYD-DNLILSRHFQLEHVEKSKRKRGKTKAAAEEPM--VTPPLIIDPLE 211

  Fly   418 --QLTP--QTLGNPGSAFQGTTVTQNQF-------------------LAPQQPLTQLPNTAQVTS 459
              ||.|  |.|....|..|......:||                   |.|::..|.||..|.||
  Fly   212 MGQLKPCAQLLVQGESVLQLCLACNSQFVDVVRFQEHLSQQHGYFQLLVPKEEPTDLPPHAMVT- 275

  Fly   460 QQIIRSPHTSTTNSQLVIRNVTNIP-PTPTTP---TSSKKAP----------------------- 497
              |..:...:..|:||      .:| |.|.||   ...|:||
  Fly   276 --IPGALALNKANAQL------QLPIPAPETPPPEQDGKEAPPSNASNDKEDLTMINDMVAVIAA 332

  Fly   498 --TFKTPSPK------QKPMPSPKSKTTVGPSS---GGSNGTSTNEFKRLITQTKPQPQVKQQQT 551
              ..||.|.|      :.|||..:.:....|.|   ...|...|::.|:|..:...||.::..|.
  Fly   333 ERVKKTSSSKVNKMIIKLPMPKKRGRKRTKPESLRDEQDNAEKTDKKKKLNKEEGQQPVLEPLQA 397

  Fly   552 AGLSASGAPTATSANQAAMQRLSSNTTITKVPKQPASLPAPAPTSNPAKL------------PML 604
            ...|......||.:|...  ::..|   .|..|:..:..|....:||..|            .:.
  Fly   398 KKTSNQAENGATQSNNVV--KVQQN---AKGSKKDGTQSAQKSETNPKHLENAETNSKDNTESVA 457

  Fly   605 NKQNITISRISMQTAPKAQSKPSTTS------PTPASQPIPVSVPALSQAQPPPLAAQHKKIVRK 663
            .|:.|...::::..|.||.::....|      .:.|:......|..:.|..|...|..|:::..:
  Fly   458 LKETIHDKQLTIDEAGKAGTQKDDNSNQKQLDKSEANAGKSKMVDQVHQQMPVESAKDHQQMTEE 522

  Fly   664 PPEN-QDTSGQKVKAARPP-------QQILPSPQ------------------------------- 689
            |..: :...|:|.:.:..|       ::|...|:
  Fly   523 PTNSTKRKRGRKERKSPTPVLIPLGDKEIKEEPELPERRMRKSRQHVDYVVEIKDEEEDDDEVEE 587

  Fly   690 ---QEGQNATHS----------------GSEAPTTSGL----ICPTCKREFKKKEHLTQHVKLHA 731
               .:..:||.|                .||....:|:    .|..|.:.||:...:..|::||.
  Fly   588 AEVDDDSSATISPHNSSTDESFTSIKRESSEESQHNGIGGIHTCNFCGKTFKRFSRMQDHLRLHT 652

  Fly   732 GLRPFKCSEEG------------------------------------------------------ 742
            |.:|:.|.:.|
  Fly   653 GEKPYVCGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKCDK 717

  Fly   743 CDKTFSRKEHLSRHLVSHSGQKMYTCEVCKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFA 807
            |:|.|.|...||.|:..|:|:|.|:|::|.|.|..:.||..|||.|.   .:....|::|:|.||
  Fly   718 CNKGFVRSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHL---GDKPIQCELCDKRFA 779

  Fly   808 TKLHYEKHREMHKKIRPESAAPGATASPAAAPALTH-VRSNG---QVPNKAVFEIKQERSAQQTQ 868
            .|:....|...|...:|.:.........:....|.| .|.:|   |||.....:.|..::|.:.:
  Fly   780 RKIDMRVHMRRHTGEKPYNCDACQRGYSSRVNLLRHQEREHGIEEQVPGSGQADKKHTKTATENE 844

  Fly   869 TQQPP 873
            .:..|
  Fly   845 QENEP 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871
		C2H2 Zn finger	710..730	CDD:275368	5/19 (26%)
		zf-C2H2	736..760	CDD:278523	9/77 (12%)
		C2H2 Zn finger	738..760	CDD:275368	9/75 (12%)
		zf-H2C2_2	752..777	CDD:290200	11/24 (46%)
		zf-C2H2	766..788	CDD:278523	10/21 (48%)
		C2H2 Zn finger	768..788	CDD:275368	9/19 (47%)
		zf-H2C2_2	780..808	CDD:290200	10/27 (37%)
		C2H2 Zn finger	799..819	CDD:275368	7/19 (37%)
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	44/195 (23%)
		C2H2 Zn finger	631..651	CDD:275368	5/19 (26%)
		zf-H2C2_2	644..666	CDD:290200	7/21 (33%)
		zf-H2C2_2	699..724	CDD:290200	3/24 (13%)
		zf-C2H2	713..735	CDD:278523	7/21 (33%)
		C2H2 Zn finger	715..735	CDD:275368	7/19 (37%)
		zf-H2C2_2	727..750	CDD:290200	10/22 (45%)
		C2H2 Zn finger	743..763	CDD:275368	9/19 (47%)
		zf-H2C2_2	755..780	CDD:290200	10/27 (37%)
		C2H2 Zn finger	771..791	CDD:275368	7/19 (37%)
		zf-H2C2_2	783..808	CDD:290200	3/24 (13%)
		C2H2 Zn finger	799..816	CDD:275370	1/16 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010