DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pad and sp4

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_956418.1	Gene:	sp4 / 387291	ZFINID:	ZDB-GENE-031202-3	Length:	714	Species:	Danio rerio

Alignment Length:	800	Identity:	187/800 - (23%)
Similarity:	287/800 - (35%)	Gaps:	254/800 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 RDAVDETGKSLSVAQSAPPVPNGAQQSGNLLNSIIQAVNMQPQQQYTITMDNGVQQQQQ------ 163
            :|::.:.|.:.:.:::|         :|..:.::  ..|...|||:.|     :|.|..
Zfish   105 KDSIQQAGANAASSEAA---------AGRKVKAV--GSNNAAQQQFQI-----IQVQNLPNSSGG 153

  Fly   164 -QHQAMP--------EVQIKSERQTALEEFIRLKPD-IKITPLGKKEPISPAKPQQQHS---LQS 215
             |:|.:|        ::||......||.    ::|: |::...|..:.|. |.||:..|   :|:
Zfish   154 IQYQVIPHLQTADGQQIQISPSNPAALS----VQPEQIQLISTGNNQAIL-ATPQRTGSASIVQN 213

  Fly   216 QTVTPTINPT-QLQLQPQLGDQLQ----------------PLWQQIQQLQLQQQLQQLT------ 257
            ||:...|.|: .||||...|.|..                |:...:.......||.|.:
Zfish   214 QTIPLQIRPSFPLQLQTIQGTQAPMVTTLPINLGGVTLALPVINNVAGAGGSVQLLQSSDGSISN 278

  Fly   258 -NQLQATTQYSVAQDDTSSSGDSKKPKLNFVLSSPTAPQFTTSMPQFGGSQPQIQLQLMPGSGGV 321
             |||..|...|.| |.|.||                     ||.....||...:    :..:.|:
Zfish   279 GNQLITTVTTSTA-DSTGSS---------------------TSTTTATGSDSVV----VTSADGL 317

  Fly   322 TSAGTVPAQTQLNAAALLSSLAGPQSTTNLLSPNKCFLPITIRDENSDQQIVAHIDTKNLVLPTT 386
            ::...|.|::..:..|.|:...|.|||:......:.|            |||.|        |..
Zfish   318 STTSMVSAESPKDNEADLTQSNGLQSTSEQAGQIQQF------------QIVGH--------PVL 362

  Fly   387 YQVQMKLQPQLATADGQPIMQLTPTSIPATLQLTPQTLGNPGSAFQGTTVTQNQFLAPQQPLTQL 451
            .|:|:: .||      |.::|       .::|:.|                 .|.|.|.|...||
Zfish   363 QQIQIQ-SPQ------QQVVQ-------GSIQIQP-----------------GQTLQPVQQNLQL 396

  Fly   452 ---PNTAQVTSQQIIRSPHTSTTNSQLVIRNVTNIPPTPTTPTSSKKAPTFKTPSPKQKPMPSPK 513
               .|.|||    :||:| |.|.:.|:                      :::|...:...||...
Zfish   397 QAFQNPAQV----LIRTP-TLTPSGQI----------------------SWQTVQVQNAGMPQQL 434

  Fly   514 SKTTVGPSSGGSNGTSTNEFKRLITQTKPQPQVKQQQTAGLSASGAPTATSANQAAMQRLSSNTT 578
            :...|..|:||  ||..                   |.|.|:..|:|...||
Zfish   435 TLAPVASSAGG--GTFA-------------------QIAPLTLGGSPITLSA------------- 465

  Fly   579 ITKVPKQPASLPAPA--PTSNPAKLPM--LNKQNITISRISMQTAPKAQSKPSTTSPTPASQPIP 639
                    |.|||.:  .|.|.|.|..  :..|.:.::...:|...:.|.....     .|.|:.
Zfish   466 --------AQLPAGSGVQTVNIAGLGAAGVQVQGVPLTITGVQGQQQGQDGVKV-----QSAPVT 517

  Fly   640 VSVPALSQAQPPPLAAQHKKIVRKPPENQDTSGQKVKAARPPQQILPSPQQ-EGQNATHSGSEAP 703
            |:|..:|.|..|....|    |:.|   .|..||..|..|......|:.:. ||:|    .|:..
Zfish   518 VTVGNISNAVSPEQMGQ----VQSP---SDQEGQPSKRLRRVACSCPNCRDGEGRN----NSDPS 571

  Fly   704 TTSGLIC--PTCKREFKKKEHLTQHVKLHAGLRPFKCSEEGCDKTFSRKEHLSRHLVSHSGQKMY 766
            .....:|  ..|.:.:.|..||..|::.|.|.|||.|:...|.|.|:|.:.|.||..:|:|:|.:
Zfish   572 KKKQHVCHMEGCGKVYGKTSHLRAHLRWHTGERPFVCNWIFCGKRFTRSDELQRHRRTHTGEKRF 636

  Fly   767 TCEVCKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFATKLHYEKHREMHKKIRPESAAPG- 830
            .|..|.|.|.|.|:|:||.:.|.             ||.....|......||.:::.....:|.
Zfish   637 ECPECSKRFMRSDHLSKHIKTHQ-------------NKKGGAALTIITTDEMEEEVDEVLGSPRI 688

  Fly   831 ---ATASPAAAPALTHVRSN 847
               ||.|..:.|| |...||
Zfish   689 VTVATLSHDSNPA-TPTTSN 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871
		C2H2 Zn finger	710..730	CDD:275368	6/21 (29%)
		zf-C2H2	736..760	CDD:278523	9/23 (39%)
		C2H2 Zn finger	738..760	CDD:275368	8/21 (38%)
		zf-H2C2_2	752..777	CDD:290200	10/24 (42%)
		zf-C2H2	766..788	CDD:278523	9/21 (43%)
		C2H2 Zn finger	768..788	CDD:275368	9/19 (47%)
		zf-H2C2_2	780..808	CDD:290200	6/27 (22%)
		C2H2 Zn finger	799..819	CDD:275368	4/19 (21%)
sp4	NP_956418.1	COG5048	<566..656	CDD:227381	33/93 (35%)
		C2H2 Zn finger	578..600	CDD:275368	6/21 (29%)
		zf-H2C2_2	592..619	CDD:290200	12/26 (46%)
		C2H2 Zn finger	608..630	CDD:275368	8/21 (38%)
		zf-H2C2_2	622..645	CDD:290200	9/22 (41%)
		zf-C2H2	636..658	CDD:278523	9/21 (43%)
		C2H2 Zn finger	638..658	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910