DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pad and egr2a

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001315333.1	Gene:	egr2a / 368241	ZFINID:	ZDB-GENE-030723-6	Length:	393	Species:	Danio rerio

Alignment Length:	332	Identity:	83/332 - (25%)
Similarity:	128/332 - (38%)	Gaps:	76/332 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 TTVGPSSGGSNGTSTNEFKRLITQTKPQPQVKQQQTAGLSASGAPTAT-SANQAAMQRLSSNTTI 579
            |:.|..|.||.....::..:::...   |.::...|      |.|..| ||.......:..:||.
Zfish   119 TSPGSFSTGSPAGPPSDCSKIVQNL---PNMEHMYT------GPPPYTCSAEGYQDPSVYLSTTT 174

  Fly   580 TKVPKQPASLPAPAPTSNPAKLPMLNK-----QNITISRISMQTAPKAQSKPSTTSPTPASQPIP 639
            ..:...|.|..||..|.:.|...::..     ||.:..|.:|......:               |
Zfish   175 CPITYAPPSYSAPKSTIDGALFSIIPDYGGFYQNSSCQRDNMAVFQDIK---------------P 224

  Fly   640 VSVPALSQAQPPPLAAQHKKIVRKPPEN---QDTSGQKVKAARPPQQILPSPQQEGQNATHSGSE 701
            .|....|...||||.          |.|   ..|....|..:|||        .:|.|
Zfish   225 FSCSLESIRVPPPLT----------PLNTIRNFTLACPVDGSRPP--------LDGTN------- 264

  Fly   702 APTTSGLICPTCKREFKKKEHLTQHVKLHAGLRPFKCSEEGCDKTFSRKEHLSRHLVSHSGQKMY 766
             |....|     :...:.:::..:..|.....||:.|..||||:.|||.:.|:||:..|:|.|.:
Zfish   265 -PQNVPL-----RPILRPRKYPNRPCKTPVHERPYPCPAEGCDRRFSRSDELTRHVRIHTGHKPF 323

  Fly   767 TCEVCKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFA--------TKLHYEKHREMHKKIR 823
            .|.:|.:.|||.|:|..|.|.||   .|..:.||.|.:.||        ||:| ::|::....:.
Zfish   324 QCRICMRSFSRSDHLTTHIRTHT---GEKPFSCDFCGRKFARSDERRRHTKIH-QRHKDRKLSVG 384

  Fly   824 PESAAPG 830
            |.|::.|
Zfish   385 PHSSSAG 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871
		C2H2 Zn finger	710..730	CDD:275368	1/19 (5%)
		zf-C2H2	736..760	CDD:278523	11/23 (48%)
		C2H2 Zn finger	738..760	CDD:275368	11/21 (52%)
		zf-H2C2_2	752..777	CDD:290200	9/24 (38%)
		zf-C2H2	766..788	CDD:278523	9/21 (43%)
		C2H2 Zn finger	768..788	CDD:275368	9/19 (47%)
		zf-H2C2_2	780..808	CDD:290200	11/35 (31%)
		C2H2 Zn finger	799..819	CDD:275368	9/27 (33%)
egr2a	NP_001315333.1	zf-C2H2	293..317	CDD:278523	11/23 (48%)
		C2H2 Zn finger	295..317	CDD:275368	11/21 (52%)
		zf-H2C2_2	309..334	CDD:290200	9/24 (38%)
		COG5048	321..>382	CDD:227381	22/64 (34%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
		zf-H2C2_2	337..362	CDD:290200	10/27 (37%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910