DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pad and sp3b

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_005165855.1	Gene:	sp3b / 322961	ZFINID:	ZDB-GENE-110815-3	Length:	783	Species:	Danio rerio

Alignment Length:	929	Identity:	206/929 - (22%)
Similarity:	323/929 - (34%)	Gaps:	299/929 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 RDAVDETGKSLSVAQSAPPVPNGAQQSGNLL-----NSIIQAV----------NMQPQQQY---- 150
            |.||...||:.|: ...|..||..:|..|.:     :.||:::          :...:.|:
Zfish     8 RCAVPSCGKTQSL-HGLPSDPNLRKQWVNFIFNEVPDRIIKSLFVCSLHFTTDSFTNKTQFDAGF 71

  Fly   151 ------------TITMDNGVQQQQQQHQAMPEVQIKSERQTALEEFIRLKPDIKITPLGKKEPIS 203
                        ||.....:|.|:..|:...|:..::|.....:...:..||:|...| |.||.|
Zfish    72 SERLKVKDDAVPTILDPKVMQPQRSSHKTSREMGCQTEELNTQDGQCQTFPDLKPHTL-KLEPRS 135

  Fly   204 -----PAKPQQQHSLQSQTVTPTINPTQLQ-LQPQLGDQLQPLWQQIQQLQLQQQLQQLTNQLQA 262
                 |||.|:..:|.       ::.:|.. |||..|.|             .||...|| .:|.
Zfish   136 ETPEQPAKQQEMAALD-------VDSSQSDFLQPASGAQ-------------DQQTTDLT-AIQM 179

  Fly   263 T---TQYSVAQDDTSSSGDSKKPKLNFV------------------LSSPTAPQFTTSMPQFGGS 306
            |   .::.|....:|..|:   |.:..|                  ::..|.|.|.|:.....|:
Zfish   180 TGSSDRWEVLTPVSSVKGE---PAVVHVPSGGLLGSNGQYVVPLQTMAGQTQPVFVTAGVDGTGA 241

  Fly   307 QPQIQLQLMP---GSGGV---------------TSAGTVPAQTQLNAAA--------LLS----- 340
            . .:|.|::|   |:.|.               |....:|..||..|.|        |||
Zfish   242 N-GVQYQVIPQLQGADGASLSYTASAADGSTLGTDIAILPDGTQGIATATNANDLQGLLSQSGHV 305

  Fly   341 ------SLAGP------QSTTNLLSPNKCFLPITIRDENSDQQIVAHIDTKNLVLPTTYQVQMKL 393
                  ||||.      |...|:..|..    ||:...||    ::::|.::|.|.....:...:
Zfish   306 QQIPTVSLAGSGFGTQGQVVANMGLPGN----ITLVPINS----LSNVDLESLGLAGAQTIATSV 362

  Fly   394 QPQLATADGQPIM-----------------------------QLTPTSIPATLQLTPQTLGNPGS 429
                 |||||.||                             ...||:..:|....|:|:...|.
Zfish   363 -----TADGQLIMTGPTTTTSDNQGESGKCTESLNANDANANAFVPTTTSSTSTSLPETIDGTGV 422

  Fly   430 AFQGTTVTQNQFLAPQQPLTQLPNTAQVTSQQIIR-SPHTSTTNSQLVIRNVTNIPPTPTTPTSS 493
            ..|.|.|:     |..|.|:.:........:|::: .|..:...:...:::|..:
Zfish   423 LTQATAVS-----AGHQDLSYIQQNHTTGGEQVVQLLPAQTADGAAQTLQSVQLL---------- 472

  Fly   494 KKAPTFKTPSPKQKPMPSPKSKTTVGPSSGGSNGTSTNEFKRLITQTKPQPQVKQQQTAGLSASG 558
             .|.||...:            .||.|:.            ::..||.....|:..|...|.|:|
Zfish   473 -NAGTFLIQA------------QTVSPTG------------QIQWQTFQVQGVQNLQNLQLPAAG 512

  Fly   559 APTATSANQAAMQRLSSNTTITKVPKQPASLPAPAPTSNPAKLPMLNKQNITISRISMQTAPKAQ 623
            .              .|:..||..|.|..||.....|....::|  |.|.:|::.:.     :.|
Zfish   513 G--------------VSSPQITLAPVQTLSLGQSGTTGALGQIP--NLQTVTVNSVG-----QYQ 556

  Fly   624 SKPSTTSPT-------PASQPIPVSVPALSQAQPPPLAAQHKKIVRKPPENQDTSGQKVKAARPP 681
            ...:|.|.|       |.|...|.|..:.|.     ||  |.: ||...|:.:.:||:.|..|..
Zfish   557 QDENTESHTDIQIKEEPESDDWPNSTLSTSD-----LA--HLR-VRLVEEDMEGTGQEGKRLRRV 613

  Fly   682 QQILPSPQQEGQNATHSGSEAPTTSGLIC--PTCKREFKKKEHLTQHVKLHAGLRPFKCSEEGCD 744
            ....|:.::.|...:..|.:...    ||  |.|.:.:.|..||..|::.|:|.|||.||...|.
Zfish   614 ACTCPNCKEAGGRGSSMGKKKQH----ICHIPGCGKVYGKTSHLRAHLRWHSGERPFICSWSYCG 674

  Fly   745 KTFSRKEHLSRHLVSHSGQKMYTCEVCKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFATK 809
            |.|:|.:.|.||..:|:|:|.:.|..|.|.|.|.|:|.||.:.|
Zfish   675 KRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTH--------------------- 718

  Fly   810 LHYEKHREMHKKIRPESAAPGATASPAAAPALTHVRSNGQVPNKAVFEIKQERSAQQTQTQQPPA 874
                    .:||....:...|.|  .||||:.|.:...|.....|        :.||..||.
Zfish   719 --------QNKKGLNSNTGVGQT--EAAAPSDTIITGGGATVILA--------NLQQAGTQD--- 762

  Fly   875 QVMHVVTTQDLAGNTITIT 893
                :::..||....:|::
Zfish   763 ----LLSNSDLPLQLVTVS 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871
		C2H2 Zn finger	710..730	CDD:275368	7/21 (33%)
		zf-C2H2	736..760	CDD:278523	10/23 (43%)
		C2H2 Zn finger	738..760	CDD:275368	9/21 (43%)
		zf-H2C2_2	752..777	CDD:290200	10/24 (42%)
		zf-C2H2	766..788	CDD:278523	9/21 (43%)
		C2H2 Zn finger	768..788	CDD:275368	9/19 (47%)
		zf-H2C2_2	780..808	CDD:290200	4/27 (15%)
		C2H2 Zn finger	799..819	CDD:275368	0/19 (0%)
sp3b	XP_005165855.1	THAP	8..85	CDD:283206	14/77 (18%)
		C2H2 Zn finger	638..660	CDD:275368	7/21 (33%)
		COG5048	<651..728	CDD:227381	32/105 (30%)
		zf-C2H2	666..690	CDD:278523	10/23 (43%)
		C2H2 Zn finger	668..690	CDD:275368	9/21 (43%)
		zf-H2C2_2	682..705	CDD:290200	9/22 (41%)
		zf-C2H2	696..718	CDD:278523	9/21 (43%)
		C2H2 Zn finger	698..718	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910