DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pad and Zfp438

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_017456046.1	Gene:	Zfp438 / 307024	RGDID:	1307214	Length:	800	Species:	Rattus norvegicus

Alignment Length:	738	Identity:	150/738 - (20%)
Similarity:	242/738 - (32%)	Gaps:	225/738 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 PVPNGAQQSGNLLNSIIQAVNMQP----QQQYTITMDNGVQQQQQQHQAMPEVQIKSERQTALEE 183
            |.|:.....|:|      |:..:|    .|.|.:....| |:......|:|.|   :..|...:.
  Rat    55 PCPSSLSDQGSL------ALMSKPLGMHTQNYALMQVAG-QEGTFSLVALPNV---ASAQPVQKP 109

  Fly   184 FIRLKPDIKITPLGKKEPISPAKPQQQHSLQSQ---TVTPTINPTQL-------QLQPQLGDQLQ 238
            .:.:..::|: |:.:.:|:|....:::|.|.|.   :..|. .|.||       |..|:|..:..
  Rat   110 RMSIHENLKL-PIPRYQPLSSKGLRKKHDLSSPKGGSRDPP-GPAQLCHLSPSPQAHPELLHKPS 172

  Fly   239 PLWQQIQQLQLQQQLQQLTNQLQATTQYSVAQDD-----TSSSGDSKKPKLNFVLSSPTAPQFTT 298
            | |:::..|.     ...||...||...::.|.|     |.|.||         |..|..|.::|
  Rat   173 P-WKRMPTLN-----PSPTNINTATVTSAIGQGDLSPLETDSCGD---------LEPPAIPAYST 222

  Fly   299 SMPQFGGSQPQIQLQLMPGSGGVTSAGTVPAQTQLNAAALLSSLAGPQSTTNLLSPNKCFLPITI 363
            .     .|.|    |.:|.|  :..||....:|                      |.|   |...
  Rat   223 E-----NSSP----QSLPAS--MQKAGCARKET----------------------PTK---PAVA 251

  Fly   364 RDENSDQQIVAHIDTKNLVLPTTYQVQMKLQPQLATADGQPIMQLTPTSIPATLQLTPQTLGNPG 428
            .:|..:|...||    ::|..|...|      .:.|.|..||:..:.......:::.|.. .|..
  Rat   252 SEELQEQVAPAH----SVVSSTVQSV------SVVTKDKLPILPSSRVKTTEVVKVEPDA-ENAE 305

  Fly   429 SAFQGTTVTQNQFLAPQQ---PLTQLPNTAQV---TSQQIIRSPHTSTTNSQLVIRNVTNIPPTP 487
            |:..|......:.|:..:   ..|::.|....   :.|...:|.....|...|         ...
  Rat   306 SSSSGCRANCEERLSITEGFDAATEIANKTPALHGSKQSACKSAFCPVTKLDL---------NRK 361

  Fly   488 TTPTSSKKAPTFKTPSPKQKPMPSPKSKTTVGPSSGGSNGTSTNEFKRLITQTKPQPQVKQQQTA 552
            ..|:|..|....|...|........|.:..:....|.|...:.|        ..|:|:.::
  Rat   362 AKPSSGVKRRGRKWKVPDDILALQGKRRRCIIGMCGDSIERARN--------NPPEPRDQK---- 414

  Fly   553 GLSASGAPTATSANQAAMQRLSSNTTITKVPKQPASLPAPAPTSNPAKLPMLNKQNITISRISMQ 617
                   |.|||....::           :||....|.|.||.::||  .||::
  Rat   415 -------PRATSRKYRSI-----------MPKPVIVLSALAPLASPA--AMLSQ----------- 448

  Fly   618 TAPKAQSKPSTTSPTPASQPIPVSVPALSQAQPPPLAAQHKKIVRKPPENQDTSGQKVKAARPPQ 682
                        :|:...|.:      |:.|.||                      |..:::...
  Rat   449 ------------APSGLGQDV------LNNALPP----------------------KCLSSKQSD 473

  Fly   683 QILPSPQQEGQNATHSGSEAPTTSGLICPTCKREFKKKEHLTQHVKLHAGLRPFKCSEEGCDKTF 747
            .:.|.|....:|. .||.:.|..   :||.|...|:.|.||..|:..|...||:.|..  |.||:
  Rat   474 NLAPKPSSALRNG-FSGIKKPWH---MCPVCNYHFQFKHHLLDHMNTHTNRRPYSCGI--CRKTY 532

  Fly   748 SRKEHLSRHLVSHSGQKMYTCEVCKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFA-TKLH 811
            .|...||.|:..|.|                ||..|           .|.||:.|.|.|. .:::
  Rat   533 VRPGSLSAHMKLHHG----------------DNRPK-----------KLVCCEFCAKVFGHVRVY 570

  Fly   812 YEKHREMHKKIRPESAAPGATAS 834
            :...:|:|:.:......|....|
  Rat   571 FGHLKEVHRVVISTEPTPSELQS 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871
		C2H2 Zn finger	710..730	CDD:275368	8/19 (42%)
		zf-C2H2	736..760	CDD:278523	8/23 (35%)
		C2H2 Zn finger	738..760	CDD:275368	8/21 (38%)
		zf-H2C2_2	752..777	CDD:290200	5/24 (21%)
		zf-C2H2	766..788	CDD:278523	3/21 (14%)
		C2H2 Zn finger	768..788	CDD:275368	3/19 (16%)
		zf-H2C2_2	780..808	CDD:290200	8/28 (29%)
		C2H2 Zn finger	799..819	CDD:275368	5/20 (25%)
Zfp438	XP_017456046.1	C2H2 Zn finger	497..517	CDD:275368	8/19 (42%)
		zf-H2C2_2	509..534	CDD:290200	10/26 (38%)
		C2H2 Zn finger	525..545	CDD:275368	8/21 (38%)
		C2H2 Zn finger	557..575	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000