DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pad and Zscan10

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001100451.1	Gene:	Zscan10 / 302962	RGDID:	1310745	Length:	778	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	160/781 - (20%)
Similarity:	262/781 - (33%)	Gaps:	255/781 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 PAKPQQQHS----LQSQTV---TPTINPTQLQLQPQLGDQLQPLWQQIQQLQLQQ---QLQQLTN 258
            |..|:|:||    |:...|   .|  .|.:.:.:|::..||...:|..:.:..:.   :|::|.|
  Rat     7 PDAPEQEHSGAVKLEEDEVGEEDP--RPAESRPRPEVAHQLFRCFQYQEDMGPRASLGRLRELCN 69

  Fly   259 QLQATTQYSVAQDDTSSSGDSKKPKLNFVLSSPTAPQFTTSMPQFGGS----QP----QIQLQLM 315
            .......::..|                :|......||.:.:|....|    ||    :..:||:
  Rat    70 HWLRPALHTKKQ----------------ILELLVLEQFLSVLPPHVLSRLHGQPLRNGEEMVQLL 118

  Fly   316 PGSGGVTSAGTVPAQTQLNAAALLSSLAGPQSTTNLLSPNKCFLPITIRDE-NSDQQIVAHIDTK 379
                    .|..|..|........|..||..:            |:.:.:| :|..|:.:|  :.
  Rat   119 --------EGVTPRDTSHTGPLDFSFSAGKNA------------PVDVSEEQSSPSQVPSH--SP 161

  Fly   380 NLVLPTTYQVQMKLQPQLATADGQPI---------MQLTPTS------IPATLQLTPQTLGNPGS 429
            ...||:  :....|.|....:..||:         .:|.|:|      .|..:...||. .||
  Rat   162 QTELPS--EESPALHPLNELSPSQPVPTKPAESEEWKLAPSSNWPMSPEPQEILQDPQE-SNP-- 221

  Fly   430 AFQGTT----VTQNQFLA-----------------PQQPL---TQLPNTAQVTSQQIIRSPHTST 470
             .||.:    .:::|.||                 |..||   :::|.:.::..::  |.|....
  Rat   222 -MQGPSGLEEDSRDQELAAVLESLTFEDTSEKRAWPANPLGVGSRMPGSEELKVEE--RKPAAIG 283

  Fly   471 TNSQLVIRNVTNIPPTPTTPTSSKKAPTFKTPSPKQKPMPSPKSKTTVGPSSGGSNGTSTNEFKR 535
            ..||                       |.| |....:|:.....|.|..|.|||:...|....:.
  Rat   284 AESQ-----------------------TDK-PGGAGEPLTQTLGKETSSPDSGGTPADSGEVVEV 324

  Fly   536 LITQTKPQPQVKQQQTAGLSASGAPTATSANQAAMQRLSSNTTITKVPKQPASLPAPAP------ 594
            ..|...|:||.:.|...        ||...|.:.|..|.::    ::...|:|.|.|:.
  Rat   325 RGTADAPKPQAEVQFIC--------TACGVNFSQMSHLQAH----QLQSHPSSQPHPSSRSFRCL 377

  Fly   595 -------TSNPAKLPM-----------------------LNKQNIT----------------ISR 613
                   .|:..||.|                       |.|..:|                ..|
  Rat   378 WCGKTFGRSSILKLHMRTHTDERPHACHLCSHRFRQSSHLRKHLLTHFSEPTFRCAECNQGFRRR 442

  Fly   614 ISMQTAPKAQSKPSTTSPTPASQPIPVSVPALSQA---------QPPPLAAQHKKIVRKPPENQD 669
            .|:.....|.::....:|.|..:   ..|||::..         |......:|.:|..|..::..
  Rat   443 SSLMQHLMAHAQEQIPTPNPEGK---TKVPAVAAVLCSHCGQTFQRRSSLKRHLRIHAKDKDHHQ 504

  Fly   670 TS-----------------GQKVKAARPPQQIL----------------------PSPQQEGQNA 695
            :|                 ....|..|..:.::                      .:.|......
  Rat   505 SSEDPGNLSSHQESESYVCSDCGKVFRQSEHLITHRRVHTRERPFSCQVCGRCFTQNSQLINHQQ 569

  Fly   696 THSGSEAPTTSGLICPTCKREFKKKEHLTQHVKLHAGLRPFKCSEEGCDKTFSRKEHLSRHLVSH 760
            .|:| |.|..    ||.|.:.|.::..|.:|:..|.||||:.|::  |.|:|.:...|:|||..|
  Rat   570 VHTG-EKPHA----CPQCSKRFVRRAGLARHLLTHGGLRPYHCAQ--CGKSFCQMRDLTRHLRCH 627

  Fly   761 SGQKMYTCEVCKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFATKLHYEKHREMHKKIRPE 825
            :|:|...|..|.:.||:..:|.:||||||   .|..:.||.|...|....:..:||..|...||.
  Rat   628 TGEKPCRCNECGEGFSQNAHLARHRRIHT---GEKPHACDTCGHRFRNSSNLARHRRSHTGERPY 689

  Fly   826 S 826
            |
  Rat   690 S 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871
		C2H2 Zn finger	710..730	CDD:275368	6/19 (32%)
		zf-C2H2	736..760	CDD:278523	8/23 (35%)
		C2H2 Zn finger	738..760	CDD:275368	8/21 (38%)
		zf-H2C2_2	752..777	CDD:290200	10/24 (42%)
		zf-C2H2	766..788	CDD:278523	8/21 (38%)
		C2H2 Zn finger	768..788	CDD:275368	8/19 (42%)
		zf-H2C2_2	780..808	CDD:290200	12/27 (44%)
		C2H2 Zn finger	799..819	CDD:275368	6/19 (32%)
Zscan10	NP_001100451.1	SCAN	39..123	CDD:153421	18/107 (17%)
		C2H2 Zn finger	341..368	CDD:275368	7/38 (18%)
		COG5048	347..770	CDD:227381	78/361 (22%)
		C2H2 Zn finger	376..396	CDD:275368	4/19 (21%)
		C2H2 Zn finger	404..424	CDD:275368	2/19 (11%)
		C2H2 Zn finger	432..452	CDD:275368	2/19 (11%)
		C2H2 Zn finger	476..496	CDD:275368	2/19 (11%)
		zf-C2H2	521..543	CDD:278523	2/21 (10%)
		C2H2 Zn finger	523..543	CDD:275368	2/19 (11%)
		zf-H2C2_2	535..560	CDD:290200	0/24 (0%)
		C2H2 Zn finger	551..571	CDD:275368	1/19 (5%)
		zf-H2C2_2	564..588	CDD:290200	8/28 (29%)
		C2H2 Zn finger	579..599	CDD:275368	6/19 (32%)
		C2H2 Zn finger	607..627	CDD:275368	8/21 (38%)
		zf-H2C2_2	619..644	CDD:290200	10/24 (42%)
		C2H2 Zn finger	635..655	CDD:275368	8/19 (42%)
		zf-H2C2_2	647..672	CDD:290200	12/27 (44%)
		C2H2 Zn finger	663..683	CDD:275368	6/19 (32%)
		zf-H2C2_2	675..700	CDD:290200	6/16 (38%)
		C2H2 Zn finger	691..711	CDD:275368	160/781 (20%)
		zf-C2H2	723..744	CDD:278523
		C2H2 Zn finger	724..744	CDD:275368
		zf-C2H2	750..772	CDD:278523
		C2H2 Zn finger	752..772	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100