DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pad and Sp1

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_036787.2	Gene:	Sp1 / 24790	RGDID:	3738	Length:	786	Species:	Rattus norvegicus

Alignment Length:	933	Identity:	208/933 - (22%)
Similarity:	311/933 - (33%)	Gaps:	318/933 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LRATCRNSQTMLNNCLNIR-PAPSSDKLYIRDAVDETGKSLS--------VAQSAPPVPNGAQQS 131
            |.|||...::...|..|.: |:.|..    ...:|.|...||        ::.|:...|...:||
  Rat    65 LAATCSRIESPNENSNNSQGPSQSGG----TGELDLTATQLSQGANGWQIISSSSGATPTSKEQS 125

  Fly   132 GNLLNSIIQAVNMQPQQ----QYTITMDNGVQQQQQ-----------QHQAMPEVQIKSERQTAL 181
            ||..|....:.:.:.:.    ||.:.....:|.||.           |:|.:|:.|....:|
  Rat   126 GNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQ--- 187

  Fly   182 EEFIRLKPDIKITPLGKKEPISPAKPQQQHSLQSQTVTPTINPTQLQLQPQLGDQLQPLWQQIQQ 246
                     ::....|       |:.||..|.|.| :.|..|...:..:...|:.:..:...:||
  Rat   188 ---------LQFAATG-------AQVQQDGSGQIQ-IIPGANQQIITNRGSGGNIIAAMPNLLQQ 235

  Fly   247 LQLQQQLQQLTNQ-LQATTQYSVAQDDTSSSGDSKKPKLNFVLSSPTAPQ-----FTTSMPQFGG 305
               ...||.|.|. |...||| |.....:.:|:.....:|.|.::...|.     .::|..|..|
  Rat   236 ---AVPLQGLANNVLSGQTQY-VTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQESG 296

  Fly   306 SQPQIQLQLMPGSGGVTSAGTVPAQTQLNAAALLSSLAGPQS--------TTNLLSPNKCFLPIT 362
            |||            |||.      |.:::|:|:||.|...|        :|...:.|...:..|
  Rat   297 SQP------------VTSG------TAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFT 343

  Fly   363 IRD-----------------ENSDQQIVAHIDTKNLVL-----------PTTYQVQMKLQPQLAT 399
            ...                 :.||...:....|....|           ..|.|.|:.:||||..
  Rat   344 SSGSSGTSSQGQTSQRVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQ 408

  Fly   400 ADGQPIMQLTPTSIPATLQLTPQTLGNPGSAFQGTTVTQNQFLAPQQPLTQLPNTAQVTSQQIIR 464
            . ||.:.         .||..|.:    |..|                      |.|..||:.::
  Rat   409 G-GQALQ---------ALQAAPLS----GQTF----------------------TTQAISQETLQ 437

  Fly   465 SPHTSTTNSQLVIRNVTNIPPTPTTPTSSKKAPTFKTPSPKQKPMPSPKSKTTVGPSSGGSNGTS 529
            :         |.::.|.|..|.           ..:||              ||||:  |.....
  Rat   438 N---------LQLQAVQNSGPI-----------IIRTP--------------TVGPN--GQVSWQ 466

  Fly   530 TNEFKRLITQTKPQPQVKQQQTAGLSASGAP-TATSANQAAMQRLSSNTTITKVPKQPASLPAPA 593
            |.:.:.|      |.|..|.||..|    || ...|..|.:    |||||:|.: ...||:||..
  Rat   467 TLQLQNL------QVQNPQAQTITL----APMQGVSLGQTS----SSNTTLTPI-ASAASIPAGT 516

  Fly   594 PTSNPAKL-PMLNKQNITISRISMQTAPKAQSKPSTTSPTPASQPIPVSVPALSQAQPPPLAAQH 657
            .|.|.|:| .|...|.|.:|.:.             ||.....|     :|.|      |||
  Rat   517 VTVNAAQLSSMPGLQTINLSALG-------------TSGIQVHQ-----LPGL------PLA--- 554

  Fly   658 KKIVRKPPE---------------NQDTSGQKVKAARPPQQILPSPQQEGQNATHSGSEAPTTSG 707
              |...|.:               :.:|:|.:      ..:..|.||.:....|.  .||.|
  Rat   555 --IANTPGDHGAQLGLHGPGGDGIHDETAGGE------EGENSPDPQPQAGRRTR--REACT--- 606

  Fly   708 LICPTCKRE--------FKKKEHLTQHVKLHAGLRPFKCSEEGCDKTFSRKEHLSRHLVSHSGQK 764
              ||.||..        .|||:|:              |..:||.|.:.:..||..||..|:|::
  Rat   607 --CPYCKDSEGRGSGDPGKKKQHI--------------CHIQGCGKVYGKTSHLRAHLRWHTGER 655

  Fly   765 MYTC--EVCKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFATKLHYEKHREMHKKIRPESA 827
            .:.|  ..|.|.|:|.|.|.:|:|.||   .|..:.|..|.|.|....|..||.:.|:.   :..
  Rat   656 PFMCNWSYCGKRFTRSDELQRHKRTHT---GEKKFACPECPKRFMRSDHLSKHIKTHQN---KKG 714

  Fly   828 APGATASPAAAPALTHVRSNGQVPNKAVFEIKQERSAQQTQTQQPPAQV------MHVVTTQDLA 886
            .||...|....|..:...|.|                  :.|..|.|.:      |..:..:.:|
  Rat   715 GPGVALSVGTLPLDSGAGSEG------------------SGTATPSALITTNMVAMEAICPEGIA 761

  Fly   887 G------NTITITQAPDSNMPGS 903
            .      |.:.:|:....|:.|:
  Rat   762 RLANSGINVMQVTELQSINISGN 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871	4/10 (40%)
		C2H2 Zn finger	710..730	CDD:275368	8/27 (30%)
		zf-C2H2	736..760	CDD:278523	8/23 (35%)
		C2H2 Zn finger	738..760	CDD:275368	8/21 (38%)
		zf-H2C2_2	752..777	CDD:290200	10/26 (38%)
		zf-C2H2	766..788	CDD:278523	9/23 (39%)
		C2H2 Zn finger	768..788	CDD:275368	9/21 (43%)
		zf-H2C2_2	780..808	CDD:290200	10/27 (37%)
		C2H2 Zn finger	799..819	CDD:275368	7/19 (37%)
Sp1	NP_036787.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94		8/32 (25%)
		Repressor domain. /evidence=ECO:0000250	2..83		6/17 (35%)
		SP1-4_N	55..628	CDD:425404	162/737 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..143		7/32 (22%)
		Transactivation domain A (Gln-rich). /evidence=ECO:0000250	147..252		27/127 (21%)
		Transactivation domain B (Gln-rich). /evidence=ECO:0000250	262..496		67/333 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..303		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..397		7/64 (11%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P08047	463..471		1/7 (14%)
		Transactivation domain C (highly charged). /evidence=ECO:0000250	497..611		39/160 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..600		5/43 (12%)
		VZV IE62-binding. /evidence=ECO:0000250	620..786		49/203 (24%)
		zf-C2H2	627..651	CDD:395048	9/37 (24%)
		C2H2 Zn finger	629..651	CDD:275368	8/21 (38%)
		zf-H2C2_2	643..670	CDD:404364	10/26 (38%)
		C2H2 Zn finger	659..681	CDD:275368	9/21 (43%)
		zf-H2C2_2	673..696	CDD:404364	9/25 (36%)
		zf-C2H2	687..709	CDD:395048	7/21 (33%)
		C2H2 Zn finger	689..709	CDD:275368	7/19 (37%)
		Domain D. /evidence=ECO:0000250	709..786		16/97 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345164
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840