DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pad and Sp1

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_038700.2	Gene:	Sp1 / 20683	MGIID:	98372	Length:	781	Species:	Mus musculus

Alignment Length:	922	Identity:	208/922 - (22%)
Similarity:	298/922 - (32%)	Gaps:	302/922 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LRATCRNSQTMLNNCLNIR-PAPSSDKLYIRDAVDETGKSLS--------VAQSAPPVPNGAQQS 131
            |.|||...::...|..|.: |:.|..    ...:|.|...||        ::.|:...|...:||
Mouse    66 LAATCSRIESPNENSNNSQGPSQSGG----TGELDLTAAQLSQGANGWQIISSSSGATPTSKEQS 126

  Fly   132 GNLLNSIIQAVNMQPQ-QQYTITMDNGVQQQQQ-----------QHQAMPEVQIKSERQTALEEF 184
            ||..|....:.|.... .||.:.....:|.||.           |:|.:|:.|....:|
Mouse   127 GNSTNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQ------ 185

  Fly   185 IRLKPDIKITPLGKKEPISPAKPQQQHSLQSQTVTPTINPTQLQLQPQLGDQLQPLWQQIQQLQL 249
                  ::....|       |:.||..|.|.| :.|..|.   |:.|..|.....:......||.
Mouse   186 ------LQFAATG-------AQVQQDGSGQIQ-IIPGANQ---QIIPNRGSGGNIIAAMPNLLQQ 233

  Fly   250 QQQLQQLTNQ-LQATTQYSVAQDDTSSSGDSKKPKLNFVLSSPTAPQFTTSMPQFGGSQPQIQLQ 313
            ...||.|.|. |...||| |.....:.:|:.....:|.|.::...|..........|||.
Mouse   234 AVPLQGLANNVLSGQTQY-VTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQE----- 292

  Fly   314 LMPGSGGVTSAGTVPAQTQLNAAALLSSLAGPQS-TTNLLSPNKCFLPITIRDENSDQQIVAHID 377
                    :|:..|.:.|.:::|:|:||.|...| .||
Mouse   293 --------SSSQPVTSGTAISSASLVSSQASSSSFFTN--------------------------- 322

  Fly   378 TKNLVLPTTYQVQMKLQPQLATADGQPIMQLTPTSIPATLQ--LTPQTLG--------------N 426
             .|....||            |.....||..|.:....|..  .|||.:|              .
Mouse   323 -ANSYSTTT------------TTSNMGIMNFTSSGSSGTSSQGQTPQRVGGLQGSDSLNIQQNQT 374

  Fly   427 PGSAFQGT----------TVTQNQFLAPQ--------QPLTQLPNTAQVTSQQIIRSPHTSTTNS 473
            .|.:.||:          |..|...:.||        |.|...|.:.|..:.|.|    :..|..
Mouse   375 SGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAI----SQETLQ 435

  Fly   474 QLVIRNVTNIPPTPTTPTSSKKAPTFKTPSPKQKPMPSPKSKTTVGPSSGGSNGTSTNEFKRLIT 538
            .|.::.|.|..|.           ..:||              ||||:  |.....|.:.:.|
Mouse   436 NLQLQAVQNSGPI-----------IIRTP--------------TVGPN--GQVSWQTLQLQNL-- 471

  Fly   539 QTKPQPQVKQQQTAGLSASGAP-TATSANQAAMQRLSSNTTITKVPKQPASLPAPAPTSNPAKL- 601
                |.|..|.||..|    || ...|..|.:    |||||:|.: ...||:||...|.|.|:|
Mouse   472 ----QVQNPQAQTITL----APMQGVSLGQTS----SSNTTLTPI-ASAASIPAGTVTVNAAQLS 523

  Fly   602 PMLNKQNITISRISMQTAPKAQSKPSTTSPTPASQPIPVSVPALSQAQPPPLAAQHKKIVRKPPE 666
            .|...|.|.:|.:.             ||.....|     :|.|      |||     |...|.:
Mouse   524 SMPGLQTINLSALG-------------TSGIQVHQ-----LPGL------PLA-----IANTPGD 559

  Fly   667 NQDTSGQKVKAARPPQQILPSPQQEGQNATHSGSEAPTTSGL-------------ICPTCKRE-- 716
            :....|            |.....:|.:...:|.|...:|.|             .||.||..
Mouse   560 HGTQLG------------LHGSGGDGIHDETAGGEGENSSDLQPQAGRRTRREACTCPYCKDSEG 612

  Fly   717 ------FKKKEHLTQHVKLHAGLRPFKCSEEGCDKTFSRKEHLSRHLVSHSGQKMYTC--EVCKK 773
                  .|||:|:              |..:||.|.:.:..||..||..|:|::.:.|  ..|.|
Mouse   613 RASGDPGKKKQHI--------------CHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGK 663

  Fly   774 PFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFATKLHYEKHREMHKKIRPESAAPGATASPAAA 838
            .|:|.|.|.:|:|.||   .|..:.|..|.|.|....|..||.:.|:.   :...||...|....
Mouse   664 RFTRSDELQRHKRTHT---GEKKFACPECPKRFMRSDHLSKHIKTHQN---KKGGPGVALSVGTL 722

  Fly   839 PALTHVRSNGQVPNKAVFEIKQERSAQQTQTQQPPAQV------MHVVTTQDLAG------NTIT 891
            |..:...|.|                    |..|.|.:      |..:..:.:|.      |.:.
Mouse   723 PLDSGAGSEG--------------------TATPSALITTNMVAMEAICPEGIARLANSGINVMQ 767

  Fly   892 ITQAPDSNMPGS 903
            :|:....|:.|:
Mouse   768 VTELQSINISGN 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871	4/10 (40%)
		C2H2 Zn finger	710..730	CDD:275368	8/27 (30%)
		zf-C2H2	736..760	CDD:278523	8/23 (35%)
		C2H2 Zn finger	738..760	CDD:275368	8/21 (38%)
		zf-H2C2_2	752..777	CDD:290200	10/26 (38%)
		zf-C2H2	766..788	CDD:278523	9/23 (39%)
		C2H2 Zn finger	768..788	CDD:275368	9/21 (43%)
		zf-H2C2_2	780..808	CDD:290200	10/27 (37%)
		C2H2 Zn finger	799..819	CDD:275368	7/19 (37%)
Sp1	NP_038700.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95		8/32 (25%)
		Repressor domain. /evidence=ECO:0000250	2..84		6/17 (35%)
		Transactivation domain A (Gln-rich). /evidence=ECO:0000250	145..250		29/127 (23%)
		Transactivation domain B (Gln-rich). /evidence=ECO:0000250	260..494		66/327 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..300		5/33 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..395		14/76 (18%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P08047	461..469		1/7 (14%)
		Transactivation domain C (highly charged). /evidence=ECO:0000250	495..608		37/158 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..595		7/43 (16%)
		VZV IE62-binding. /evidence=ECO:0000250	617..781		49/203 (24%)
		C2H2 Zn finger	626..648	CDD:275368	8/21 (38%)
		COG5048	<639..710	CDD:227381	26/76 (34%)
		zf-H2C2_2	640..667	CDD:290200	10/26 (38%)
		C2H2 Zn finger	656..678	CDD:275368	9/21 (43%)
		zf-H2C2_2	670..693	CDD:290200	9/25 (36%)
		zf-C2H2	684..706	CDD:278523	7/21 (33%)
		C2H2 Zn finger	686..706	CDD:275368	7/19 (37%)
		Domain D. /evidence=ECO:0000250	706..781		16/97 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841786
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840