DRSC/TRiP Functional Genomics Resources

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Protein Alignment pad and EGR1

DIOPT Version :9

Sequence 1:NP_650534.2 Gene:pad / 41981 FlyBaseID:FBgn0038418 Length:924 Species:Drosophila melanogaster
Sequence 2:NP_001955.1 Gene:EGR1 / 1958 HGNCID:3238 Length:543 Species:Homo sapiens


Alignment Length:534 Identity:132/534 - (24%)
Similarity:195/534 - (36%) Gaps:137/534 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   466 PHTSTTNSQLVIRNVTNIPPTPTTPTSSKKAPTFKTPSPKQKPMPSPKSKTTVGPSSGGSNGTST 530
            ||:.|         :.|.|........|..||.|...:...:...|..|.::.|...||..|:::
Human    24 PHSPT---------MDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGSNSSSSSSGGGGGGGGGSNS 79

  Fly   531 NEFKRLITQTKPQPQVKQQQTAGLSASGAPTATSANQAAMQRLSSNTTITKVPK---------QP 586
            :...   :...||....:|....|:|...|..:..|:..:...|..:..|::|.         :|
Human    80 SSSS---STFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETSYPSQTTRLPPITYTGRFSLEP 141

  Fly   587 A--------------------SLPAPAPTSNPAKLPMLNKQNITISRISMQTAPKAQSKPSTTS- 630
            |                    |:..|..:|:.|..|..:      |..:.|:.|.:.:.||..| 
Human   142 APNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAAS------SASASQSPPLSCAVPSNDSS 200

  Fly   631 -----------------PTPASQPIPVSVPALSQAQPP--PLAAQHKKIVRKP----PENQDTSG 672
                             |.|.||..|.|.....|..||  |.|....::...|    |:.|...|
Human   201 PIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPAAKGGFQVPMIPDYLFPQQQGDLG 265

  Fly   673 QKVKAARPPQQILPSPQQEGQN--------ATHSGSE---APTT---SGLICPTCKREFKKKEHL 723
            ......:|.|.:....||....        ||.|||:   |..|   |.||.|:..|::..:...
Human   266 LGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSK 330

  Fly   724 TQHVKLHAGLRPFKCSEEGCDKTFSRKEHLSRHLVSHSGQKMYTCEVCKKPFSRKDNLNKHRRIH 788
            |...:     ||:.|..|.||:.|||.:.|:||:..|:|||.:.|.:|.:.|||.|:|..|.|.|
Human   331 TPPHE-----RPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTH 390

  Fly   789 TQTSTETLYCCDVCNKNFATKLHYEKHREMH-----KKIRPESAAPGATASPAAAPALTHVRSNG 848
            |   .|..:.||:|.:.||.....::|.::|     ||......|..||:|.::.|         
Human   391 T---GEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSATSSLSSYP--------- 443

  Fly   849 QVPNKAVFEIKQERSAQQTQTQQPPAQVMHVVTTQDLAGNTITITQAPDS-NMPGSLANY---VQ 909
                          |...|....|      |.|:......|...:..|.| :.||| :.|   |.
Human   444 --------------SPVATSYPSP------VTTSYPSPATTSYPSPVPTSFSSPGS-STYPSPVH 487

  Fly   910 LGFSQFQNPSASVA 923
            .||     ||.|||
Human   488 SGF-----PSPSVA 496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
padNP_650534.2 zf-AD 16..87 CDD:214871
C2H2 Zn finger 710..730 CDD:275368 3/19 (16%)
zf-C2H2 736..760 CDD:278523 10/23 (43%)
C2H2 Zn finger 738..760 CDD:275368 10/21 (48%)
zf-H2C2_2 752..777 CDD:290200 10/24 (42%)
zf-C2H2 766..788 CDD:278523 9/21 (43%)
C2H2 Zn finger 768..788 CDD:275368 9/19 (47%)
zf-H2C2_2 780..808 CDD:290200 10/27 (37%)
C2H2 Zn finger 799..819 CDD:275368 6/19 (32%)
EGR1NP_001955.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..105 20/92 (22%)
DUF3446 135..209 CDD:314753 13/79 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 165..213 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..284 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 318..339 5/25 (20%)
zf-C2H2 338..362 CDD:306579 10/23 (43%)
C2H2 Zn finger 340..362 CDD:275368 10/21 (48%)
zf-H2C2_2 354..379 CDD:316026 10/24 (42%)
C2H2 Zn finger 370..390 CDD:275368 9/19 (47%)
zf-H2C2_2 382..407 CDD:316026 10/27 (37%)
C2H2 Zn finger 398..418 CDD:275368 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 409..487 21/107 (20%)
DUF3432 447..530 CDD:288743 19/62 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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