DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pad and Gfi1b

DIOPT Version :9

Sequence 1:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001153878.1	Gene:	Gfi1b / 14582	MGIID:	1276578	Length:	363	Species:	Mus musculus

Alignment Length:	393	Identity:	90/393 - (22%)
Similarity:	134/393 - (34%)	Gaps:	89/393 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   447 PLTQLPNTAQVTSQQIIRSPHTSTTNSQLVIRNVTNIPPTPTTPTSSKKAPTFKTPSPKQKPMPS 511
            ||...|..:|......|:.......|..|  ..:.:.|..|..           ||.|:....|.
Mouse    44 PLLSTPLPSQTLDWNTIKQEREMLLNQSL--PKMASAPEGPLV-----------TPQPQDGESPL 95

  Fly   512 PKSKTTVGPSSGGSNGTSTNEFKRLITQTKPQPQVKQQQTAGLSAS----GAPTATSANQAAMQR 572
            .:|.....||.  |..|..:.:....|||.     ...|:|.|..|    |:|...|.......|
Mouse    96 SESPPFYKPSF--SWDTLASSYSHSYTQTP-----STMQSAFLERSVRLYGSPLVPSTESPLDFR 153

  Fly   573 LSSN--------TTITKVPKQPASLPAPAPTSNPAKLP----MLNKQNITISRISMQTAPKAQSK 625
            |..:        ....||...|..|......|:....|    :..|.......:...|...:|..
Mouse   154 LRYSPGMDTYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDVCGKTFGHAVSLEQHTHVHSQGV 218

  Fly   626 PSTTSPTPASQPIPVSVPALSQAQPPPLAAQHKKIVRKPPENQDTSGQKVKAARPPQQILPSPQQ 690
            |:.:||||.     ::||.|.                                .||....|.|:.
Mouse   219 PAGSSPTPT-----LAVPGLE--------------------------------APPAPDPPGPRF 246

  Fly   691 EGQNATHSGSEAPTTSGLICPTCKREFKKKEHLTQHVKLHAGLRPFKCSEEGCDKTFSRKEHLSR 755
            ..|..:..           |..|.:.||:...|:.|:.:|:..||:.|  :.|.|.|.:|..:.:
Mouse   247 LRQERSFE-----------CRMCGKAFKRSSTLSTHLLIHSDTRPYPC--QFCGKRFHQKSDMKK 298

  Fly   756 HLVSHSGQKMYTCEVCKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFATKLHYEKHREMHK 820
            |...|:|:|.:.|:||.|.||:..||..|.|.||....   :.|::|.|.|..|:...:|||...
Mouse   299 HTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKP---FSCELCTKGFQRKVDLRRHRESQH 360

  Fly   821 KIR 823
            .::
Mouse   361 NLK 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pad	NP_650534.2	zf-AD	16..87	CDD:214871
		C2H2 Zn finger	710..730	CDD:275368	6/19 (32%)
		zf-C2H2	736..760	CDD:278523	6/23 (26%)
		C2H2 Zn finger	738..760	CDD:275368	6/21 (29%)
		zf-H2C2_2	752..777	CDD:290200	9/24 (38%)
		zf-C2H2	766..788	CDD:278523	10/21 (48%)
		C2H2 Zn finger	768..788	CDD:275368	10/19 (53%)
		zf-H2C2_2	780..808	CDD:290200	10/27 (37%)
		C2H2 Zn finger	799..819	CDD:275368	8/19 (42%)
Gfi1b	NP_001153878.1	C2H2 Zn finger	165..186	CDD:275368	4/20 (20%)
		C2H2 Zn finger	194..214	CDD:275368	2/19 (11%)
		zf-C2H2	253..275	CDD:278523	6/32 (19%)
		C2H2 Zn finger	255..275	CDD:275368	6/19 (32%)
		COG5048	263..>340	CDD:227381	27/81 (33%)
		C2H2 Zn finger	283..303	CDD:275368	6/21 (29%)
		zf-H2C2_2	295..320	CDD:290200	9/24 (38%)
		C2H2 Zn finger	311..331	CDD:275368	10/19 (53%)
		C2H2 Zn finger	339..356	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000