Protein Alignment CG17930 and SLC2A3

DIOPT Version :10

• Sequence 1: NP_650533.1
• Gene: CG17930 / 41979
• FlyBaseID: FBgn0038416
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 107/507 - (21%)
• Similarity: 186/507 - (36%)
• Gaps: 156/507 - (30%)

  Fly    89 AVSANTL-EFQYSWFIGVI----------IGAVVS----------AITSAFLPKIVFYGLGGVMN 132
            |::..|: .||:.:..|||          |...::          .:||.:...:..:.:||::.
Human    13 AITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIG 77

  Fly   133 LIDAIIFVS--------------------------APYEYESILAARYVGGVGIGLIT--VPFLI 169
            .....:||:                          .....|.::..|.|.|:..||.|  ||..|
Human    78 SFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYI 142

  Fly   170 HSAEIASSTNRGTCCALEQYGLALGVAIQVIY--------DSQWSQGLGMTINRVHGIFGIVFTA 226
              .||:.:..||....|.|.|:.:|:.:..|:        :..|...||.||          ..|
Human   143 --GEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTI----------LPA 195

  Fly   227 IALGSVAITI--DSPIF-YIRQNQEQKARASVKQLMGSYWTREAGDRAYDEAKLYVVEGSAQGVG 288
            | |.|.|:..  :||.| .|.:.:|:.|:..:::|.|:                   :..:|.:.
Human   196 I-LQSAALPFCPESPRFLLINRKEEENAKQILQRLWGT-------------------QDVSQDIQ 240

  Fly   289 EQLGES--MMPFLKLLLFRCFVAFTFSVPLSYSI-LTTTELVEG--TLHSWPTIIF--------- 339
            |...||  |....::.:...|...::..|:..|| |..::.:.|  .:..:.|.||
Human   241 EMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPI 305

  Fly   340 ------GLLRLIGALITFAVLDTVGRKFVSLLGLMCMA--------GLMLGMAGVYGDYGHIFDD 390
                  |::..|..:::..:::..||:.:.::||..||        .|:|.            |:
Human   306 YATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLK------------DN 358

  Fly   391 Y-FMWQVCRLGMAFQFFAGF---------FICSSSAYLGEAFPMRVKPFLIGLIVCLEQVIHIIV 445
            | .|..|| :|....|.|.|         ||      :.|.|....:|..:.:..|.....:.:|
Human   359 YNGMSFVC-IGAILVFVAFFEIGPGPIPWFI------VAELFSQGPRPAAMAVAGCSNWTSNFLV 416

  Fly   446 IVKFVPTAEFY---YTYFVAVGIIMVIGLVAFAVL-MPETRGLTLRQAGERF 493
            .:.| |:|..|   |.:.:..|.:  |..:||... :|||||.|.......|
Human   417 GLLF-PSAAHYLGAYVFIIFTGFL--ITFLAFTFFKVPETRGRTFEDITRAF 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17930	NP_650533.1	MFS	98..488	CDD:475125	103/490 (21%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	104/496 (21%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)