Protein Alignment CG17929 and SLC2A4

DIOPT Version :10

• Sequence 1: NP_650532.2
• Gene: CG17929 / 41978
• FlyBaseID: FBgn0038415
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_001033.1
• Gene: SLC2A4 / 6517
• HGNCID: 11009
• Length: 509
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 116/539 - (21%)
• Similarity: 199/539 - (36%)
• Gaps: 140/539 - (25%)

  Fly    34 QINSSTSNPGSVRQINKQINVACAVFFLYVYGGMDFAHSAG------------WNQ--------- 77
            ||.|....|...|...   .:..|||.. |.|.:.|.::.|            :|:
Human     7 QIGSEDGEPPQQRVTG---TLVLAVFSA-VLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPE 67

  Fly    78 -----------TLNTTATQVFK-----CSWFIGVLA---GAALASLTMTFLPKLPFYVLGG-LMQ 122
                       ||...:..:|.     .|:.||:::   |...|.|....|.     |||| ||.
Human    68 GPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLA-----VLGGSLMG 127

  Fly   123 LTGSIIFTCKPFDYGCLLAARYVAGAGIGLIT--VPFLIHSAEVATDNHRGVSGSMEQCGLALGI 185
            |..:..      .|..|:..|::.||..||.:  ||..:  .|:|..:.||..|::.|..:.:||
Human   128 LANAAA------SYEMLILGRFLIGAYSGLTSGLVPMYV--GEIAPTHLRGALGTLNQLAIVIGI 184

  Fly   186 AIQVIYDTQWVDDKEASVNEVHGIIGI--VFSIIGLGMTALSI-----------ESPIYYLRIKQ 237
            .|             |.|..:..::|.  ::.:: ||:|.|..           |||.|...|:.
Human   185 LI-------------AQVLGLESLLGTASLWPLL-LGLTVLPALLQLVLLPFCPESPRYLYIIQN 235

  Fly   238 KE-KARKCHAKLLGSFNHSVDQEFEEIQLYVAE--SQKRTFCQELRISVVPFIKLLLYRGFVAFS 299
            .| .|||...:|.|         :.::...:||  .:||...:|..:|::..:....:|..:..:
Human   236 LEGPARKSLKRLTG---------WADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIA 291

  Fly   300 FSLPLSESL---------IKSALLTEGFISCWPVTVW-GLVRLLGALVAQGFLDKLGRKFVSLVG 354
            ..|.||:.|         ..|...|.|.......|:. |:|..:..||:...:::.||:.:.|:|
Human   292 VVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLG 356

  Fly   355 L--LCMAILMLCMAASYANPANALMTYYMYQVWRLGLAFQAFAGLFVCSSSVYLGEAFPIKVKPF 417
            |  :|...:::.:|........| |:|...      :|...|...|         |..|..:..|
Human   357 LAGMCGCAILMTVALLLLERVPA-MSYVSI------VAIFGFVAFF---------EIGPGPIPWF 405

  Fly   418 FVGYIIGFEQTIHIINIVGYNKGYENFF----YHY---------YLSVGIILLVGVVFFGIVIPE 469
            .|..:.........:.:.|::....||.    :.|         :|...::||...:|..:.:||
Human   406 IVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPE 470

  Fly   470 TKKTTLREATKLFQRLQNI 488
            |:..|..:.:..|.|..::
Human   471 TRGRTFDQISAAFHRTPSL 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17929	NP_650532.2	MFS	90..477	CDD:475125	98/433 (23%)
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269|PubMed:16647043	7..13		3/5 (60%)
		MFS_GLUT_Class1	26..474	CDD:340989	108/500 (22%)
		Dileucine internalization motif. /evidence=ECO:0000269|PubMed:8300557	489..490		0/1 (0%)