DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mat89Ba and nol6

DIOPT Version :9

Sequence 1:	NP_650530.2	Gene:	Mat89Ba / 41973	FlyBaseID:	FBgn0261286	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001011358.1	Gene:	nol6 / 496825	XenbaseID:	XB-GENE-994692	Length:	1145	Species:	Xenopus tropicalis

Alignment Length:	1166	Identity:	375/1166 - (32%)
Similarity:	581/1166 - (49%)	Gaps:	140/1166 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GTQAIAHAGDHSDLDEPKPKIAKSDPPSTAIPKKNNFKQREGTKNVKPPTLEEMKELRDTQNLFH 88
            |..|:..|.|..::..| .|::|||                   ..||||.:|:..|::|::|||
Frog    36 GKSAVKRAPDADEVLRP-VKLSKSD-------------------LYKPPTNDELNRLKETEHLFH 80

  Fly    89 SNLFKLQVKEMLEELQLKQKYTDFIENWLESFTAFTRQLKD----GLMERTH---------LEVP 140
            :||.::|::|:|:|::||:|....|:.:|.........:.:    .|.::|.         |:||
Frog    81 TNLLRMQIEELLQEVKLKEKRRKTIDGFLREINTLLGTIPETPQTDLTDQTWLPDSIKVPILQVP 145

  Fly   141 MKLSEKPTGFVFSKPTREPYLIGAAATGTLLGPKIVVDVALEMPKESLHKEDYLNLRYDQKRALY 205
            .::..|   |.|..|: ...::|:...||.:.|:|.||:|:.||:|.|..:|.||.||.:|||||
Frog   146 YQVKGK---FCFLPPS-SIKVVGSYLLGTCIKPEINVDLAVTMPQEILQAKDNLNQRYSRKRALY 206

  Fly   206 LTYVTERMMESPDYAEDQFNFNYYANNPLKPVLELIPVTKQVNKHLQVRLFITAPLSSFKPGRFV 270
            |.::...:..:..::  ...|.|..:|.|||||.|.|..|. .|.:.||:.:..|...||..|..
Frog   207 LAHIASHLANNELFS--SVKFTYMNSNHLKPVLLLRPYGKD-EKLVTVRIHVCPPPGFFKISRLY 268

  Fly   271 PWNNNIRPSFYGDEWDEKDPLPSTQHYNANVLFDLTLSENQAQLDKAFKSRRNFQDGLLLLKVWL 335
            |..||:|.::|.::..|....|.|.|||..:|.||||..:...|..........:|.:.||||||
Frog   269 PNKNNVRTAWYTEQETEGVNEPPTPHYNNTILSDLTLEHHLHHLSNCASDFPGMKDAVALLKVWL 333

  Fly   336 RQRQLDIGYSGFGAHILAAFIVYLNTQRILHQSSSSYQVARTVWNQLANTDWT-KGISLSVAPIQ 399
            .|||||.||..|...:.|..|.||.::..:::..|.|||.|.....||.||.| .||:::.:...
Frog   334 HQRQLDKGYGCFNGFLAAMLISYLLSKNKINKVMSGYQVLRNTLQFLATTDLTVNGITMATSTDS 398

  Fly   400 T-EELNKFAEHYDVCFIDFTGQHNLCANIPLYLYQRVREEAKLAVELLNDMKLNSFPLIFMQKCP 463
            : ..|:.|.|.:.|.|:|..|..||||::....|.:::.||:.::::|:|...:.|.|:.|...|
Frog   399 SLPSLHDFHEAFQVVFVDPLGVVNLCADMTTNKYHQIQFEARESLKVLDDTSADGFHLLLMVPKP 463

  Fly   464 LYSRVDNILKISNYS-----C-----INQMLTLHSHPRIKYDFANYGYPQLLHLLTELLKKGLAE 518
            .....|::..::|.|     |     :||::....      |:.....|.:|    .:|.|||..
Frog   464 FVRTFDHVFHLTNVSKLQGTCKKMKLLNQLIDQGG------DYLATSLPYVL----SILSKGLGP 518

  Fly   519 RVHSILPLETATAAWPVEKKAPVIGKY-----IQLGLILQPEHAYQVLNKGPAANDDHEGAEEFR 578
            ||..:.........|.:.::.   .|:     :.:||:|:.|....||.|||||  |...|.:||
Frog   519 RVALLSHTLPHRPEWDIGEEP---AKHRDSSLLSVGLLLEAELHTSVLEKGPAA--DSSQALDFR 578

  Fly   579 RFWGEKSNLRRFQDGSITEAVVWGTAQDSPAKKRLIVRQIVLHLLEHHLQLDSKEVQYIGGELDQ 643
            .||||||.|||||||||.|||||  ...|..:||.:...||.:|||.|..:....:.|.|..||.
Frog   579 AFWGEKSELRRFQDGSICEAVVW--PGSSLCEKRKVPELIVKYLLELHADIPESCISYTGNVLDC 641

  Fly   644 VYQLSPWFKVNKLKTKLPLGQD--TDAEALSPHVIRCYDELARQLHGLNDLPLEIVSISGVSPIF 706
            |               |..|::  |:.|.: ..:|:.||:|:|:|..|.||||.:.|:.|..|..
Frog   642 V---------------LTRGKEAGTEEEKM-VGIIQSYDDLSRKLWNLTDLPLTVTSVQGTHPCL 690

  Fly   707 RYCE---PQPVLPQ----ALLVENRILASSIQ----------RVVIQLGQSGKWPTELGALRALK 754
            ||.:   |.||.|.    .||.|.:.|..:.:          :|:..:..|||||.:..|::.:|
Frog   691 RYSDVFPPLPVKPDWSSYQLLREKKCLVPNPEKPCPAYVAPVKVICHMEGSGKWPQDKDAIKRVK 755

  Fly   755 TAFLIEIGEKLEAQCRLHWVMSADGLLVLKQGYCFLIELAHNKELALLKQEVTERGITTYIDNAA 819
            .||.|.:.|.|.||.:|....||....|.|.||.|.:::|:::|...:|:.||..|:..|.|...
Frog   756 AAFQIRLAELLRAQHQLLCNPSATHTDVYKDGYVFRVQVAYHREPQYMKEIVTPEGMLKYQDTEE 820

  Fly   820 SRSLERQHYILPKVSGALHSLHQTYSAFGSTVLLAKRWLATQLLDDGLWPDMATELLVAHLF--Q 882
            |..||.:...||.::..||.|||.:.|||.|..:||||:.:|||.|. :.:...:|||||||  .
Frog   821 SLQLELETLHLPSLTSTLHGLHQQHPAFGGTSRMAKRWIHSQLLGDS-FSEECVDLLVAHLFLHP 884

  Fly   883 QRYAPQSIAAPQTGFIRFLQLLSHSDFNGELFLLNFNNSWQEQQIADLEHNYRSNRQSYPPLAVA 947
            ..|:|.|  :||.||:|||.||:..|:.....::|.|...:.....::::::.|.|...|.:.:|
Frog   885 APYSPPS--SPQVGFLRFLHLLATFDWKNSPLIVNLNGELKGPDYTEIQNDFISARAQLPVMFIA 947

  Fly   948 TSYDMQHAGRLWTSDQSPSQRVLGHVTRLARHALEIIETSLM----SKDLRFVRPAQLFRASNEG 1008
            |..|.:.:  |||..| |:.::|..:..|...:|..:|..||    |:|.:..     ||...:.
Frog   948 TPKDKKDS--LWTKTQ-PTAQILQRLIVLCLESLRALEQQLMDPSGSQDYKMT-----FRPPLDL 1004

  Fly  1009 YDLVIQFKPDLVPNSLSYDLGSPFVSFSQ---------PNFSLPRAGSDYIARIVGLLRSAYSDF 1064
            ||::|:..|..:|.... .:..|..||.:         .:...|..|.|.:...:..||.||.:|
Frog  1005 YDILIRLNPKQIPRHRE-AVDQPAKSFFRGLLKEGAQVKDLMFPVVGYDPVQCYLQELREAYGEF 1068

  Fly  1065 AAFFYNPHGGKELGIVWRPPTEFAAKPFKVTELQACSPCGNKKVQVL---KETLLEDFKLL 1122
            |.||::.|||..:|::|: |:.|..:|||.|.:......|.....:|   .|.::|||::|
Frog  1069 ALFFHDKHGGDVIGVLWK-PSGFEPQPFKTTNMTGRVMDGKSAKPLLVPNVEAIVEDFEIL 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mat89Ba	NP_650530.2	Nrap	166..1130	CDD:281764	335/1011 (33%)
nol6	NP_001011358.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		3/9 (33%)
nol6	NP_001011358.1	Nrap	165..1137	CDD:281764	335/1013 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41505
Inparanoid	1	1.050	509	1.000	Inparanoid score	I1287
OMA	1	1.010	-	-		QHG54062
OrthoDB	1	1.010	-	-		D148067at33208
OrthoFinder	1	1.000	-	-		FOG0003992
OrthoInspector	1	1.000	-	-		otm47676
Panther	1	1.100	-	-	LDO	PTHR17972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1619
SonicParanoid	1	1.000	-	-		X2755
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110