DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment asun and Ints13

DIOPT Version :9

Sequence 1:	NP_524379.2	Gene:	asun / 41971	FlyBaseID:	FBgn0020407	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_001349035.1	Gene:	Ints13 / 71177	MGIID:	1918427	Length:	740	Species:	Mus musculus

Alignment Length:	753	Identity:	272/753 - (36%)
Similarity:	408/753 - (54%)	Gaps:	121/753 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFERNQKTIFVLDHTRYFSIASEEYISMDFL-KGKPSADGGATGAAGNATGSGGSQFSKSLWTCA 64
            :|..:.||:||:||..|.:.:..:::..|.| |.:..   |....|         ..|||||||:
Mouse     3 IFSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQ---GIIPLA---------PISKSLWTCS 55

  Fly    65 CESSIEYCRVVWDLFPGKKHVRFIVSDTAAHIVNTWRPSTQNMAHVMNAMLIVGVPS-RNVPTSS 128
            .|||:||||:::|:||.||.|.|||||:.||::|:|....||:..:|.|:..||.|: |..|...
Mouse    56 VESSMEYCRIMYDIFPFKKLVNFIVSDSGAHVLNSWTQEDQNLQELMAALATVGPPNPRADPECC 120

  Fly   129 DYSVIHGLRAAIEALAEPTDEQLAAMADFGTDELPRIPNKGRVICITSARDNTSMKSLEDIFNTV 193
              |::|||.||:|.|.:.|:.|..|.. ...:...|:.|:||:||||:|:.::.::.|||.....
Mouse   121 --SILHGLVAAVETLCKITEYQHEART-LLMENAERVGNRGRIICITNAKSDSHVRMLEDCVQET 182

  Fly   194 LVQQNTLAAPPSKKGLVIDHCHLVILNIVPLGVESLVTNRSLLKISPLLDVEIHTVSA-PDISYK 257
            :.:.|.||| .|...:.|..|.||:::..|:|.:|||::|...::||:|..|:|:|.| ..::.|
Mouse   183 IHEHNKLAA-NSDHLMQIQKCELVLIHTYPVGEDSLVSDRPKKELSPVLTSEVHSVRAGRHLATK 246

  Fly   258 LTHLILNHYDLASTTVTNIPMK--------EEQNANSSANYDVEILHSRRAH--SITCGPDFSLP 312
            |..|:..|:||||||:||||||        |||:||:|||||||:||.:.||  .:..|...| .
Mouse   247 LNVLVQQHFDLASTTITNIPMKPTFSVFEQEEQHANTSANYDVELLHHKDAHVDFLRSGDSHS-G 310

  Fly   313 TSIKQGATYETVTLKWCTPRGCGSADLQPCLGQFLVTPVDVTSRPSSCLINFLLNGRSVLLEMPR 377
            :|.::|...||||||||||| ..|.:|..|.|.:.::||||.|||||||.||||||||||||.||
Mouse   311 SSSREGPFKETVTLKWCTPR-TNSIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPR 374

  Fly   378 KTGSKATSHMLSARGGEIFVHSLCITRSCMDEAPSITDGPGGRVSDYRTAELGQLIKMSRVVPL- 441
            |:|||..|||||:.|||||:|.|..:||.:::.|||::|.||||:|||..:.|:.::.:|:.|.
Mouse   375 KSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLTPFL 439

  Fly   442 ----KVKDPSAPPLTR------RLPRYFPLTTSSSILFHLQRHISWLPHFLHLLVKEDMDKQDEV 496
                |:......||.|      :..||:|:..|.:.:|::|..:.    ...::|||.:.::|.:
Mouse   440 DPRYKIDASLEIPLERAKDQLEKHTRYWPMIISQTTIFNMQAVVP----LAGVIVKESLTEEDVL 500

  Fly   497 RCQQHIHELYKSASRGDVLPFTHTNGARLKLSKAKDQYRLLYRELEQLIQLN-ATTMHHKNLLES 560
            .||:.|:.|.....:.|.||.: |.|.|.|..|..:|||:::.|||.|::.: :.:..|:.:||.
Mouse   501 NCQKTIYNLVDMERKNDPLPVS-TVGTRGKGPKRDEQYRIMWNELETLVRAHISNSEKHQRVLEC 564

  Fly   561 LQSLR-------------------------AAYGDAPLKSEPGASLLRTYTE------------- 587
            |.:.|                         |.......|:.|.|..|:...|
Mouse   565 LMACRSKPPEEEERKKRGRKREDREDKSEQAGKEHGTEKARPDADRLKGILERGKEELAEAEVIK 629

  Fly   588 -SPLSPE--RLEPISSVGASGSSSSNSLLKASKRRMSSCGQRSLLDIISS-AERSQSNKRLDFSG 648
             ||.|||  ..:|:.      .:.....::.||      |..|||.:.|: ...:.|.|..:|:|
Mouse   630 DSPDSPEPPNKKPLV------ETDETPHMEKSK------GPVSLLSLWSNRINTANSRKHQEFAG 682

  Fly   649 RLCTPLGQVAKLYPDFGTKDKDTVTTGASITPNVKEES 686
            ||                   ::|...|.:..::|||:
Mouse   683 RL-------------------NSVNNRAELYQHLKEEN 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
asun	NP_524379.2	DUF2151	5..665	CDD:287224	266/726 (37%)
Ints13	NP_001349035.1	DUF2151	7..698	CDD:313450	268/744 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	572..658		14/97 (14%)
		Nuclear localization signal (NLS). /evidence=ECO:0000269\|PubMed:23904267	580..590		0/9 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831314
Domainoid	1	1.000	414	1.000	Domainoid score	I668
eggNOG	1	0.900	-	-		E1_KOG3711
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10043
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1799
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46401
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007401
OrthoInspector	1	1.000	-	-		oto94043
orthoMCL	1	0.900	-	-		OOG6_106582
Panther	1	1.100	-	-	LDO	PTHR12955
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3526
SonicParanoid	1	1.000	-	-		X6285
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790