DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment asun and ints13

DIOPT Version :9

Sequence 1:	NP_524379.2	Gene:	asun / 41971	FlyBaseID:	FBgn0020407	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	XP_017210439.1	Gene:	ints13 / 334292	ZFINID:	ZDB-GENE-030131-6224	Length:	712	Species:	Danio rerio

Alignment Length:	738	Identity:	269/738 - (36%)
Similarity:	399/738 - (54%)	Gaps:	124/738 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFERNQKTIFVLDHTRYFSIASEEYISMDFLKGKPSADGGATGAAGNATGSGGSQFSKSLWTCAC 65
            ||..:.||.||:||..|.:.:|.:.|..|.|  ..|...|....|         ..:|||||||.
Zfish     3 MFSVSHKTAFVVDHCPYMAESSRQLIECDML--TKSRSQGVIPLA---------PVAKSLWTCAV 56

  Fly    66 ESSIEYCRVVWDLFPGKKHVRFIVSDTAAHIVNTWRPSTQNMAHVMNAMLIVGVPS-RNVPTSSD 129
            |.|:||||:::|::|.||.|.:||||:..||:|:|:...||...:|:|:..||.|: |..|...
Zfish    57 ECSMEYCRILYDIYPTKKLVNYIVSDSEVHILNSWKQEDQNTHDLMSALAAVGPPNPRQDPECC- 120

  Fly   130 YSVIHGLRAAIEALAEPTDEQ------LAAMADFGTDELPRIPNKGRVICITSARDNTSMKSLED 188
             ||:|||.||:|:|.:.|:.|      |..|||       |:.|:||:||:|:|:.:|.::.|||
Zfish   121 -SVLHGLVAAVESLCKITEYQHESRTTLMDMAD-------RVANRGRIICLTNAKSDTHVRMLED 177

  Fly   189 IFNTVLVQQNTLAAPPSKKGLVIDHCHLVILNIVPLGVESLVTNRSLLKISPLLDVEIHTVSAPD 253
            .....:.:||.||| .|.:.:.|..|.||:::|.|.|.::||::|...::|.:|..|:|:|.|..
Zfish   178 CVLETIQEQNKLAA-GSDRLMPIQQCELVLVHIYPQGDDTLVSDRQKKELSSVLSSEVHSVRAGR 241

  Fly   254 -ISYKLTHLILNHYDLASTTVTNIPMK--------EEQNANSSANYDVEILHSRRAHS--ITCGP 307
             ::.||..|:..|:||||||:||||||        |||:||:|||||||:||.|.||.  |..|.
Zfish   242 YLACKLNVLVQQHFDLASTTITNIPMKPTLNVCEQEEQHANTSANYDVELLHHRDAHMEFIKSGD 306

  Fly   308 DFSLPTSIKQGATYETVTLKWCTPRGCGSADLQPCLGQFLVTPVDVTSRPSSCLINFLLNGRSVL 372
            .....::.:.....||||||||||| ..|.:|..|.|.:.::||||.|||||||.||||||||||
Zfish   307 LHMAGSTSRDSGLKETVTLKWCTPR-TNSVELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVL 370

  Fly   373 LEMPRKTGSKATSHMLSARGGEIFVHSLCITRSCMDEAPSITDGPGGRVSDYRTAELGQLIKMSR 437
            ||.|||:|||..|||||:.|||||:|.|..|||.:::.|||::|.||||:|||..:.|:.::.:|
Zfish   371 LEQPRKSGSKVISHMLSSHGGEIFLHVLNSTRSTLEDPPSISEGCGGRVTDYRITDFGEFMRENR 435

  Fly   438 VVPL---KVKDPSAPPLTR------RLPRYFPLTTSSSILFHLQRHISWLPHFLHLLVKEDMDKQ 493
            :.|.   .|......|:.|      |..||:|:..|.:.:|::|..:.    ..:|:||:.:.::
Zfish   436 LTPFPDSMVDAAGRAPIERAKSQLERHTRYWPMIISQTTIFNMQAVVP----LANLIVKDTLTEE 496

  Fly   494 DEVRCQQHIHELYKSASRGDVLPFTHTNGARLKLSKAKDQYRLLYRELEQLIQLN-ATTMHHKNL 557
            |.:.||:.::.|.....:.|.||.: |.|:|.|..|..:|||:::.|||.|::.: .|:..|:.:
Zfish   497 DVLTCQKTVYNLVDMERKSDPLPIS-TVGSRGKGPKRDEQYRIMWNELETLVKTHVGTSERHQRV 560

  Fly   558 LESLQSLRAAYGDAPLKSEPG---------------------------------------ASLLR 583
            ||.:.:.|:...:...:.:.|                                       .|...
Zfish   561 LECISACRSKPPEEEERKKRGRKREDKEDKTEKNGKDTEEKSWTADTERLKGVMDREKDEQSECE 625

  Fly   584 TYTESPLSPERLEPISSVGASGSSSSNSLLKASKRRMS---------SCGQRSLLDI-ISSAERS 638
            ...:||.|||.|.                   .|.|::         |.|..|||.: .:...::
Zfish   626 IIKDSPDSPEPLN-------------------KKPRLATEEQQPPEKSKGPVSLLALWTNRITQA 671

  Fly   639 QSNKRLDFSGRLCTPLGQVAKLY 661
            .|.|..:|:||| :.:...|:||
Zfish   672 NSRKHQEFAGRL-SSVNNKAELY 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
asun	NP_524379.2	DUF2151	5..665	CDD:287224	267/734 (36%)
ints13	XP_017210439.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574298
Domainoid	1	1.000	414	1.000	Domainoid score	I640
eggNOG	1	0.900	-	-		E1_KOG3711
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10043
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1785
OMA	1	1.010	-	-		QHG46401
OrthoDB	1	1.010	-	-		D300303at33208
OrthoFinder	1	1.000	-	-		FOG0007401
OrthoInspector	1	1.000	-	-		oto39390
orthoMCL	1	0.900	-	-		OOG6_106582
Panther	1	1.100	-	-	LDO	PTHR12955
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3526
SonicParanoid	1	1.000	-	-		X6285
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800