DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment asun and ints-13

DIOPT Version :9

Sequence 1:	NP_524379.2	Gene:	asun / 41971	FlyBaseID:	FBgn0020407	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_499881.1	Gene:	ints-13 / 176839	WormBaseID:	WBGene00019822	Length:	782	Species:	Caenorhabditis elegans

Alignment Length:	807	Identity:	194/807 - (24%)
Similarity:	317/807 - (39%)	Gaps:	161/807 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFERNQKTIFVLDHTRYFSIASEEYISMDFLKGKPSADGGATGAAGNATGSGGSQFSKSLWTCAC 65
            |.:|:.||:|:||.:..|.....|...:...:|.....               .||.|::||...
Worm     1 MEQRDMKTVFLLDRSAKFVENCNETFDVTIREGPKQKK---------------LQFEKTIWTWCL 50

  Fly    66 ESSIEYCRVVWDLFP-GKKHVRFIVSDTAAHIVNT-WRPSTQNMAHVMNAMLIVGVPSRNVPTSS 128
            |...|..|::.|::| |...:||.::|....:::| |.........:...:..|..||.   .::
Worm    51 EGIFEMHRILSDVYPRGTLQLRFALADFMGKMLDTQWTDGFLTREELGELIETVSRPSE---ANT 112

  Fly   129 DYSVIHGLRAAIEALAEPTDEQLAAMADF----------------------GTDELPRIPNKGRV 171
            |.:.|.||..||||||..:.||.....|.                      |...||.:.|.|.:
Worm   113 DITPIGGLTMAIEALAVQSPEQRNYNYDVRYSANKRTAQNSEVIRVTRELRGLPPLPTVQNAGNL 177

  Fly   172 ICITSARDNTSMKSLEDIFNTVLVQQNTLAAPPSKKGLV-IDHCHLVILNIVPLGVESLVTNRSL 235
            |..|.......|:.|:.....::|.:|.:|..||.|... |....|.|:|....|.|..|...||
Worm   178 IMYTRLNTQEEMEQLQTEIVELVVSRNKIADAPSNKTFCPITSLRLFIVNYYATGDECTVKTHSL 242

  Fly   236 LKIS--PLLDVEIHTVSAPDISYKLTHLILNHYDLASTTVTNIPMKEEQNANSSANYDVEILHSR 298
            ....  |||.:.:.:..|.|:...:..|:::.:||.|||||.|||||:.  ..|:|||||:.||.
Worm   243 QAHPDLPLLKIWVISRKAADMCDAIHSLLVDAFDLGSTTVTKIPMKEDN--RGSSNYDVELFHSG 305

  Fly   299 RAHSITCGPDFSLPTSIK----QGATYETVTLKWCT-PRG-------CGSADLQPCLGQFLVTPV 351
            :.|::....:.....|.|    :|.||:|:.|.|.| |:.       .|:|  .||      |..
Worm   306 KVHAMLKENNLIDTVSKKGDSDKGVTYDTMRLTWTTAPKTKWSLFPYHGAA--VPC------TTA 362

  Fly   352 DVTSRPSSCLINFLLNGRSVLLEMPRKT------GSKATSHMLSARGGEIFVHSLCITRSCMD-- 408
            ...||||:||..|:.:||.|:|:..:.|      ..|..||:|.|..|.||:..:...:...|
Worm   363 QAYSRPSACLTQFVRDGRCVMLDSEKTTELGMNMHEKLVSHLLIANRGRIFIQEIDFMQKKADRI 427

  Fly   409 ----EAPSITDGPGGRVS------DYRTAELGQLIK--MSRVVPLK-------VKDPSAPPLTRR 454
                :.|.:...|...::      .|:..||..:.|  |...:..|       :|:.......:|
Worm   428 AGKLKRPRVLHAPEDPINMNQLRHTYKQLELRFVAKNRMDDNLTEKETEKWTGLKNSDLKKRFQR 492

  Fly   455 LPRYFPLTTSSSILFHLQRHISWLPHFLHLLVKEDMDKQDEVRCQQHIHELYKSASRGDVLPFTH 519
            :.:..|...:.:.:|: ::....|...:.|:.|..:.:.|..:|:|.|..||:..:...   :..
Worm   493 ISKNIPCFAADTFIFN-EKVTPKLEPLISLITKTTLSENDVDKCKQCIVTLYQMKNERQ---YVI 553

  Fly   520 TNGARLKLSKAK------DQYRLLYREL--------------EQLIQLNATTMHHKNLLE-SLQS 563
            :..:.:|:|..:      :|.|:.:.||              :::.:...||::...||| .|..
Worm   554 SPESDIKISSVRNLKDPDEQLRVTFVELAKHIMKYVTFSEKHKEIYKTYMTTLNVDKLLEVDLDD 618

  Fly   564 LRAA---------YG--DAPLKSEPGASLLRTYTESPL-SPERLEPISSVGASGSSSSNSLL-KA 615
            ..|.         :|  |...|::..........|..| ||...:....|.|........|. :.
Worm   619 DEAVDKMFVKFSFFGKSDTASKTDEDEDSSDDEDEEILKSPALKKLFGYVDARDERKYEELYGQG 683

  Fly   616 SKRRMSSCGQRSL-------LDIISS----AERSQSNKRLDFSGRLCTPLGQVAKLYPDFGTK-- 667
            .|::.....::.:       :||.|:    .|..:|..|.:|.||  ...|.:|.|||....|
Worm   684 FKKKKPEVEEKPIVMAKEIKVDIFSNMCDMLEVKESKIRREFVGR--ETHGNIAPLYPQLAEKLE 746

  Fly   668 --------------DKDTVTTGASITP 680
                          .::|...|.|.||
Worm   747 RPASPAATERGTERVRNTAERGGSGTP 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
asun	NP_524379.2	DUF2151	5..665	CDD:287224	186/770 (24%)
ints-13	NP_499881.1	DUF2151	2..744	CDD:370894	187/775 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156452
Domainoid	1	1.000	144	1.000	Domainoid score	I2858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10043
Inparanoid	1	1.050	145	1.000	Inparanoid score	I3027
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46401
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007401
OrthoInspector	1	1.000	-	-		oto19937
orthoMCL	1	0.900	-	-		OOG6_106582
Panther	1	1.100	-	-	LDO	PTHR12955
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3526
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890