DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and SV2A

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001315603.1	Gene:	SV2A / 9900	HGNCID:	20566	Length:	742	Species:	Homo sapiens

Alignment Length:	682	Identity:	132/682 - (19%)
Similarity:	216/682 - (31%)	Gaps:	266/682 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVDYVLEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSV 65
            :|..|  |.::.:.|. |::|:..:|:..|:.:..|:.:              |:.|.
Human   148 LAQQY--EAILRECGH-GRFQWTLYFVLGLALMADGVEV--------------FVVGF------- 188

  Fly    66 TPWNSSAILAAIPLKPNGELESCLMFDPSSPGTNTTINCERYVYDTTYYKTSRTIDWNFVCDRRW 130
                         :.|:.|.:.||  ..|:.|                                .
Human   189 -------------VLPSAEKDMCL--SDSNKG--------------------------------M 206

  Fly   131 MGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFMVARYLLGI 195
            :|.||    .||:..||...|||||::||:.....|.....:.....:|:..|.:|:..|.|.|
Human   207 LGLIV----YLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSG- 266

  Fly   196 VGSAGAYICGFVLTMELVGPTKRTVCG--ITFQAVF--AGGIMLVAGWGALIPDRQW---LQVIY 253
            ||..|:....|....|.:...||   |  :::..:|  .||:...|...|:||...|   :...|
Human   267 VGIGGSIPIVFSYFSEFLAQEKR---GEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAY 328

  Fly   254 GLHG-------CLF-----LGHWWWLDESPRWLWMQGRAAEAVDIVAK----GLRINGSGIPVDK 302
            ..|.       |.|     :|......||||:....|:..||..::.:    .:|..|....|..
Human   329 QFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFS 393

  Fly   303 EYYVQKAKQQ-AAAEEKSSAG---------------------LSDLFRTPNLRMKTLNVCLCWFA 345
            ..:::...|: ...|.:|..|                     ||..  .|..|..||.:...||.
Human   394 VTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCF--GPEYRRITLMMMGVWFT 456

  Fly   346 NSLVYYGLSL---------------SAGKLY---------------------------------- 361
            .|..||||::               |..|::
Human   457 MSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRL 521

  Fly   362 ------------------------------------------------------------GNP-- 364
                                                                        |.|
Human   522 KSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLD 586

  Fly   365 -----------YLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGG--LCCIVAAYIAQGS 416
                       |.:.|:..|...|..|....::|::||     ..||.|.  :.|:...:::.|:
Human   587 VTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGR-----LRMLAGSSVMSCVSCFFLSFGN 646

  Fly   417 TTSTAVVMA---GKLLIAGSFAVIYNYSAELFPTVVRNSAMG-LGSMCARLSGALTPLITLLDSF 477
            :.|..:.:.   |.:.|| |:..:...:.||:|:..|.:|.| |.::| :|:..|.  |::..||
Human   647 SESAMIALLCLFGGVSIA-SWNALDVLTVELYPSDKRTTAFGFLNALC-KLAAVLG--ISIFTSF 707

  Fly   478 --DPKIPAVLFGVVALISG-FWVMFLPETMNQ 506
              ..|...:||...||..| ...:.||||..|
Human   708 VGITKAAPILFASAALALGSSLALKLPETRGQ 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	129/668 (19%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	110/546 (20%)
SV2A	NP_001315603.1	synapt_SV2	1..742	CDD:130366	132/682 (19%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..144
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940