DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and SLC22A13

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_004247.2	Gene:	SLC22A13 / 9390	HGNCID:	8494	Length:	551	Species:	Homo sapiens

Alignment Length:	570	Identity:	169/570 - (29%)
Similarity:	272/570 - (47%)	Gaps:	65/570 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNSSAIL 74
            ::.::|:||::|.....|..:....:..:..:.|.:.....|.|.:..|.|.:.:::.  :..::
Human     7 VLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLSA--AEQLV 69

  Fly    75 AAIPLKPNGELESCLMFDPSSPGTNTTINCERYVYDTTYYKTSRT----IDW------------- 122
            .::||...|..|.||||.|  |..|.::.      |...::.:.|    :.|
Human    70 LSVPLDTAGHPEPCLMFRP--PPANASLQ------DILSHRFNETQPCDMGWEYPENRLPSLKNE 126

  Fly   123 -NFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSF 186
             |.||||:.:....|:|||.|:..|.:..|.|.|::|||.......|...:||:..||:|.:..:
Human   127 FNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELY 191

  Fly   187 MVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAG--WGALIPDRQW- 248
            |..|:.:. ...||.......|..|.|||:.||...:..|..|:.|.|::||  :|.    |.|
Human   192 MALRFAVA-TAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGF----RNWR 251

  Fly   249 -LQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDKEYYVQKAKQQ 312
             ||:.....|.|...::|.|.||.|||..:||..||:.::.|...:|       :.....:...|
Human   252 LLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVN-------RRKLSPELMNQ 309

  Fly   313 AAAEEKSSAGLS-DLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMGLVEF 376
            ...|:...:|.: ||||.|.||..||.:...||.:||.||||||..|....:.||...|.|.||.
Human   310 LVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEV 374

  Fly   377 PSYITIVFVLDRLGRR-SITSTLMLGGGLCCIVAAYIAQGSTTSTAVVMAGKLLIAGSFAVIYNY 440
            |:..:.:|::.|.||: |...||:|||.:|.|:....|......|.:.:.||:..|.:|.:.|.|
Human   375 PARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVY 439

  Fly   441 SAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLPETMN 505
            |||||||::|.:.|||..:.:|:.|.||||:.||..:...:|.:::|.:.:::|.....||||..
Human   440 SAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHG 504

  Fly   506 QPMPESIEDGENFGKGDTWFSQCAGRKKRQNSVYPDDPEQMVPLKNIESK 555
            |.:.::::|.| .|.                  :|..|:.:...|..|:|
Human   505 QGLKDTLQDLE-LGP------------------HPRSPKSVPSEKETEAK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	161/518 (31%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	127/376 (34%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	161/519 (31%)
		MFS	139..500	CDD:119392	127/372 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551		8/44 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		otm41229
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	8.060