DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_445989.2	Gene:	Slc22a7 / 89776	RGDID:	621699	Length:	535	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	171/535 - (31%)
Similarity:	263/535 - (49%)	Gaps:	38/535 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNSSA 72
            |||:.|:|.||.:|.....|..|..:...||.|..|.:||||.|.|.:.|...:......|
  Rat     4 EDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLLPVFMAAVPAHHCALPGAPANLSHQDLW---- 64

  Fly    73 ILAAIPLKPNGELESCLMF-------------------DPSSPGTNTTINCER-YVYDTTYYKTS 117
            :.|.:|.:.:|...|||.|                   :|.  |...|:.|.: :.||.:.:.::
  Rat    65 LEAHLPRETDGSFSSCLRFAYPQTVPNVTLGTEVSNSGEPE--GEPLTVPCSQGWEYDRSEFSST 127

  Fly   118 RTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPE 182
            ...:|:.||.:|.:..|..|.|.:||..|||..|.|:|:.||:.:...:.:..|::|:..|....
  Rat   128 IATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAYVSSLVLGLMSAASIN 192

  Fly   183 YFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQ 247
            |..|:|.|.|.| ...||..|....|.:|.:....|||.|:.....::||::|:|..|.||...:
  Rat   193 YIMFVVTRTLTG-SALAGFTIIVLPLELEWLDVEHRTVAGVISTVFWSGGVLLLALVGYLIRSWR 256

  Fly   248 WLQVIYGL---HGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDKEYYVQKA 309
            ||.:...|   .|.:.:   ||:.||.|||..|||..||...:....::||.  ||.:....|:|
  Rat   257 WLLLAATLPCVPGIISI---WWVPESARWLLTQGRVEEAKKYLLSCAKLNGR--PVGEGSLSQEA 316

  Fly   310 KQQAAAEEKSSAGLS--DLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMG 372
            .......|::....|  |||||..||..:|...:.||..:..||||:|....|..|.|....:.|
  Rat   317 LNNVVTMERALQRPSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTLDVSGLGLNVYQTQLLFG 381

  Fly   373 LVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIA-QGSTTSTAVVMAGKLLIAGSFAV 436
            .||.||.|.:.|::.|||||...:.::||..|....:..:: :..:..||:|:.||.....:|..
  Rat   382 AVELPSKIMVYFLVRRLGRRLTEAGMLLGAALTFGTSLLVSLETKSWITALVVVGKAFSEAAFTT 446

  Fly   437 IYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLP 501
            .|.:::||:|||:|.:.:||.::..||..:|.||..|||.....:|.|.:|.:||::....:.||
  Rat   447 AYLFTSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLPKVAYGGIALVAACTALLLP 511

  Fly   502 ETMNQPMPESIEDGE 516
            ||....:||:|:|.|
  Rat   512 ETKKAQLPETIQDVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	162/520 (31%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	123/376 (33%)
Slc22a7	NP_445989.2	2A0119	11..521	CDD:273328	163/521 (31%)
Slc22a7	NP_445989.2	MFS	144..511	CDD:119392	123/372 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020