DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and slc22a7a

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001077330.1	Gene:	slc22a7a / 794188	ZFINID:	ZDB-GENE-050506-52	Length:	560	Species:	Danio rerio

Alignment Length:	540	Identity:	164/540 - (30%)
Similarity:	258/540 - (47%)	Gaps:	45/540 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDN--SSLSVTPWNS 70
            ||::.::|.|.|:|||..::..|..:...:|.|....::.||.|.|.:..:|.  |:........
Zfish     4 EDVLREIGGFNKFQFLVLYILWLPRVILPLHFLLHNFISGVPPHHCALPRLDGRFSASGAEKEEL 68

  Fly    71 SAILA-AIPLKPNGELESCLM------FDPSSP-------GTNTTINCER-YVYDTTYYKTSRTI 120
            :.|:| .||...:|...||.|      ||.:..       .:|.::.|:. :|||.:.:.::...
Zfish    69 AQIVALGIPRNSDGSYSSCKMYTMPMDFDLNGDLSVLYGNRSNVSVPCQNGWVYDRSQFTSTTAT 133

  Fly   121 DWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFS 185
            :|:.|||.:.:...:.|.|.:||..|||..|.|:||.|||.:...|.:...:.|:..||...|..
Zfish   134 EWDLVCDNKKLNQALATFFFIGVTMGAVVFGQLSDKFGRKPMIQVSFVSSAVFGIIEAFSSSYVM 198

  Fly   186 FMVARYLLGIVGSAGAYICGFVLT----------MELVGPTKRTVCGITFQAVFAGGIMLVAGWG 240
            |.:||.|           |||.||          :|......||..|......::.|.||:|...
Zfish   199 FAIARTL-----------CGFALTGMSITTVALCVEWTDVKHRTFTGTIISLGWSVGNMLLALLA 252

  Fly   241 ALIPDRQWLQVIYGLHGCLFLG--HWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDKE 303
            .||  |.|..:|..:.....:|  .|||:.||.|||...||..||...:....::||. ....|:
Zfish   253 YLI--RDWRHLILVVTSPCLVGIIAWWWIPESARWLLANGRVEEAQKYLINCAKMNGK-YSYTKK 314

  Fly   304 YYVQKAKQQAAAEEKS-SAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLI 367
            ..::..|:...||:.: :....||.|||.||...|...:.|||.:..|||:|.:......|.||.
Zfish   315 LDIENLKKITIAEDSNKNHSYLDLVRTPKLRKIVLCSGIFWFAVAFTYYGISFNITGFGLNIYLT 379

  Fly   368 LFIMGLVEFPSYITIVFVLDRLGRRSITS-TLMLGGGLCCIVAAYIAQGSTTSTAVVMAGKLLIA 431
            .||.|::|.|:.:.....|||:|||:..: :|::.|.|..:.:....:.:...|.:.:.||....
Zfish   380 QFIYGVIEVPAKVGTYLTLDRIGRRNGQAWSLIIAGALIGLNSVIPTEFAAVRTGIAVIGKGFSE 444

  Fly   432 GSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFW 496
            .:|.:.:.|::||:|||:|...:|..|..||:.|:|.|::.|.:......|.|:|...|:.||..
Zfish   445 AAFTIAFLYTSELYPTVLRQCGLGYTSFIARIGGSLAPMVILFEDIWHYGPPVVFSATAVFSGCV 509

  Fly   497 VMFLPETMNQPMPESIEDGE 516
            |..||||.|..:||:|.|.|
Zfish   510 VFLLPETTNVQLPENILDVE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	157/525 (30%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	118/384 (31%)
slc22a7a	NP_001077330.1	2A0119	11..523	CDD:273328	157/525 (30%)
slc22a7a	NP_001077330.1	MFS	148..514	CDD:119392	118/379 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.050