Protein Alignment CG6126 and SLC22A3

DIOPT Version :9

• Sequence 1: NP_650528.1
• Gene: CG6126 / 41967
• FlyBaseID: FBgn0038407
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 169/573 - (29%)
• Similarity: 279/573 - (48%)
• Gaps: 76/573 - (13%)

  Fly     8 EDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSV----TP- 67
            ::.:.::||||::|...|.|..|:|:|.....:.:|.:...|:| .:..|...::|:.    :|
Human     5 DEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDH-YWCRGPSAAALAERCGWSPE 68

  Fly    68 --WNSSAILAAIPLKPNGELESCLMFDPSSPGTNTTINCERYVYDTT------------------ 112
              ||.:|..:..| :|           |...|     .|:||:.:..
Human    69 EEWNRTAPASRGP-EP-----------PERRG-----RCQRYLLEAANDSASATSALSCADPLAA 116

  Fly   113 ----------------YYKTSRTI--DWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGR 159
                            |.:...||  :::.||...||..:.|.:..||..|||.|||..||:.||
Human   117 FPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGR 181

  Fly   160 KTVFCWSALFQLIIGVGVAFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGIT 224
            ..::..|.|...:.||.|||.|.:..|::.|:|.|:.|. |.::..:|:..|:||..:|.:.||.
Human   182 IVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGK-GTWMTCYVIVTEIVGSKQRRIVGIV 245

  Fly   225 FQAVFAGGIMLVAGWGALIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAK 289
            .|..|..||:::.|....||:.|.:|:...|...|||.::|.:.||||||..:.:..:|:.|:.:
Human   246 IQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRR 310

  Fly   290 GLRINGSGIPVDKEYYVQKAKQQAAA--EEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYG 352
            ..:.||.        |:.....:...  ||.|:....||.|||.:|..||.:...||.:::||.|
Human   311 IAKCNGK--------YLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQG 367

  Fly   353 LSLSAGKLYGNPYLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQG-S 416
            |.:..|.:.||.|:..||.|:||.|..:.|:..::|||||...:...:..|:.|:|.|::.:| :
Human   368 LVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIA 432

  Fly   417 TTSTAVVMAGKLLIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTP-LITLLDSFDPK 480
            ...|.|...|:|.|..:|.::|..::||:||.:||..:.|.|......|.:.| |:..|.:...:
Human   433 WLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLE 497

  Fly   481 IPAVLFGVVALISGFWVMFLPETMNQPMPESIEDGENFGKGDTWFSQCAGRKK 533
            :|.::||::|.|.|..||.||||....:||:::|.|..|...:  .:|...||
Human   498 LPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHS--CKCGRNKK 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	161/541 (30%)
		MFS	130..501	CDD:119392	126/374 (34%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	162/542 (30%)
		MFS	149..518	CDD:119392	126/377 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.030