Protein Alignment CG6126 and Sv2a

DIOPT Version :9

• Sequence 1: NP_650528.1
• Gene: CG6126 / 41967
• FlyBaseID: FBgn0038407
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_071313.1
• Gene: Sv2a / 64051
• MGIID: 1927139
• Length: 742
• Species: Mus musculus
• Alignment Length: 682
• Identity: 132/682 - (19%)
• Similarity: 214/682 - (31%)
• Gaps: 266/682 - (39%)

  Fly     1 MAVDYVLEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSV 65
            :|..|  |.::.:.|. |::|:..:|:..|:.:..|:.:              |:.|.
Mouse   148 LAQQY--ETILRECGH-GRFQWTLYFVLGLALMADGVEV--------------FVVGF------- 188

  Fly    66 TPWNSSAILAAIPLKPNGELESCLMFDPSSPGTNTTINCERYVYDTTYYKTSRTIDWNFVCDRRW 130
                         :.|:.|.:.||  ..|:.|                                .
Mouse   189 -------------VLPSAEKDMCL--SDSNKG--------------------------------M 206

  Fly   131 MGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFMVARYLLGI 195
            :|.||    .||:..||...|||||::||:.....|.....:.....:|:..|.:|:..|.|.|
Mouse   207 LGLIV----YLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSG- 266

  Fly   196 VGSAGAYICGFVLTMELVGPTKRTVCG--ITFQAVF--AGGIMLVAGWGALIPDRQW---LQVIY 253
            ||..|:....|....|.:...||   |  :::..:|  .||:...|...|:||...|   :...|
Mouse   267 VGIGGSIPIVFSYFSEFLAQEKR---GEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAY 328

  Fly   254 GLHG-------CLF-----LGHWWWLDESPRWLWMQGRAAEAVDIVAK----GLRINGSGIPVDK 302
            ..|.       |.|     :|......||||:....|:..||..::.:    .:|..|....|..
Mouse   329 QFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFS 393

  Fly   303 EYYVQKAKQQ-AAAEEKSSAG---------------------LSDLFRTPNLRMKTLNVCLCWFA 345
            ..:::...|: ...|.:|..|                     ||..  :|..|..||.:...||.
Mouse   394 VTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCF--SPEYRRITLMMMGVWFT 456

  Fly   346 NSLVYYGLS---------------------------------------LSAGKLYGNP------- 364
            .|..||||:                                       :..|..|.|.
Mouse   457 MSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRL 521

  Fly   365 ----------------------------------------------------------------- 364
                                                                             
Mouse   522 KSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGCPLD 586

  Fly   365 -----------YLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGG--LCCIVAAYIAQGS 416
                       |.:.|:..|...|..|....::|::||     ..||.|.  |.|:...:::.|:
Mouse   587 VTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGR-----LRMLAGSSVLSCVSCFFLSFGN 646

  Fly   417 TTSTAVVMA---GKLLIAGSFAVIYNYSAELFPTVVRNSAMG-LGSMCARLSGALTPLITLLDSF 477
            :.|..:.:.   |.:.|| |:..:...:.||:|:..|.:|.| |.::| :|:..|.  |::..||
Mouse   647 SESAMIALLCLFGGVSIA-SWNALDVLTVELYPSDKRTTAFGFLNALC-KLAAVLG--ISIFTSF 707

  Fly   478 --DPKIPAVLFGVVALISG-FWVMFLPETMNQ 506
              ..|...:||...||..| ...:.||||..|
Mouse   708 VGITKAAPILFASAALALGSSLALKLPETRGQ 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	129/668 (19%)
		MFS	130..501	CDD:119392	110/546 (20%)
Sv2a	NP_071313.1	synapt_SV2	1..742	CDD:130366	132/682 (19%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..145

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030