DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and slc22a13b

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_017209322.1	Gene:	slc22a13b / 556601	ZFINID:	ZDB-GENE-061013-532	Length:	549	Species:	Danio rerio

Alignment Length:	577	Identity:	191/577 - (33%)
Similarity:	280/577 - (48%)	Gaps:	73/577 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VDYVLEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTP 67
            :|:.  .::..:||||.:|........|..:....||...|..|....|.|
Zfish     2 IDFT--QILSSVGEFGAFQKRLLVAVCLPNIFTAFHMFGQVFTAISFPHYC-------------- 50

  Fly    68 WNSSAIL-------------AAIPLKPNGELESCLMFDP--------SSPGTNTTINC-ERYVYD 110
             |||.||             ..:||...|:.|||.||.|        ...|.|||.:| :.:||.
Zfish    51 -NSSWILRQAPNLTEEKQLNLTVPLDSKGQYESCKMFTPVEMDIEDIEHYGINTTTSCIDGWVYK 114

  Fly   111 TTYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGV 175
            .....::...:::.||:.:......|:::|.|:..||:..|.:|||.||:.....|...|.:.||
Zfish   115 APKDSSTLITEFDLVCENKVYSEASQSIYMAGLLVGALLFGPMADKYGRRFATLLSLFLQFLSGV 179

  Fly   176 GVAFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAG-- 238
            ||||.|..:.::..|:::|...| |..|..|||..|..|..||.:..|.....||.|:||::|
Zfish   180 GVAFSPNIYVYIALRFVVGTTIS-GISINTFVLGTEWCGSAKRALFTILSHCFFAIGLMLLSGVA 243

  Fly   239 WGALIPDRQW--LQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVD 301
            :|.    |.|  ||::......||..::|.|.||.|||..||:...|...:.|..||||..:
Zfish   244 YGI----RNWRVLQLVLSAPVGLFFIYYWILPESARWLLTQGKLDSAKREILKAARINGRKV--- 301

  Fly   302 KEYYVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYL 366
            .|..:.|.:.:..|:   |:.:.||||...||.:.|.:|..||..||||||:||:.|....:.||
Zfish   302 SENLLDKMEAENTAK---SSTMIDLFRVGYLRKRALIMCYMWFVTSLVYYGVSLNVGNFGLDIYL 363

  Fly   367 ILFIMGLVEFPSYITIVFVLDRLGRRSITS-TLMLGGGLCCIVAAYIAQGSTTSTAVVMAGKLLI 430
            ...|.|:.|||:.::...::.|.|||...| .|:|||..|.|:.|..|:.....|.:.:.||..:
Zfish   364 TQLIFGMAEFPARLSCFPLIQRFGRRICQSVVLLLGGTACLIIPAIPAKYPIVVTVIAVIGKFSL 428

  Fly   431 AGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGF 495
            |.||:::|.|:|||:|||||.:.:||.|||||::|.|.|||.|||.:...||.:::|.:..:.|.
Zfish   429 AASFSIVYVYTAELYPTVVRQNGVGLNSMCARVAGILAPLIGLLDVYHHAIPMIIYGSLPFVGGA 493

  Fly   496 WVMFLPETMNQ--------PMPESIEDGENFGKGDTWFSQCAGRKK---RQNSVYPD 541
            ....||||:|.        |..||:...|  .|.:.|     ||::   |:.|...|
Zfish   494 LTFLLPETLNTDLQDHTDIPADESMTVTE--VKLERW-----GRRRGWDRERSTSQD 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	180/529 (34%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	139/375 (37%)
slc22a13b	XP_017209322.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.060