DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and Orct2

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	206/568 - (36%)
Similarity:	293/568 - (51%)	Gaps:	56/568 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSS--LSVTPWNSSAILAA 76
            ||:||:||.:.:||..|:.:....|.|:.|.:.|.|:.||.:...:.||  |....||.|
  Fly    10 LGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWNLS----- 69

  Fly    77 IPLKPNGELESCLMFD------------PSSPGTNTTINCERYVYDTTYYKTSRTIDWNFVCDRR 129
            .|     |.|.|..:|            |.|  :|.|..|..||||.:.|..|...:||.||.|.
  Fly    70 YP-----ENERCSYYDVDYTEEYLNGSIPRS--SNETKTCSSYVYDRSKYLNSAVTEWNLVCGRD 127

  Fly   130 WMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFMVARYLLG 194
            :|.|...::|||||..|::..|.|:||.|||.:...|.:.|::.||.....||||::..||.::|
  Fly   128 FMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVG 192

  Fly   195 IVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQWLQVIYGLHGCL 259
            .. ::|.::..:|:.||:|||.||...||.....|:.|.||.|.:...:.|.:|||:...|.|.:
  Fly   193 AT-TSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLI 256

  Fly   260 FLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRING--------SGIPVDKEYYVQKAKQQAAAE 316
            |:.::|.:.||.|||.::||...|:..:.|..|.|.        |.:..:.|...:||||:...:
  Fly   257 FMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENSEEKAKQKLEDQ 321

  Fly   317 EKSSA---GLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMGLVEFPS 378
            |....   .:.|||..||||.|||.:.|.|...|.||||||.:...|.||..|...|.|.||.|:
  Fly   322 ELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAVEIPA 386

  Fly   379 YITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQG-STTSTAVVMAGKLLIAGSFAVIYNYSA 442
            ||.::..|:|.|||||....::..||..:....|.|. .|...|..|.|||.|..|:..:|.:||
  Fly   387 YIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITASYGTVYIFSA 451

  Fly   443 ELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLPETMNQP 507
            |.|||||||.|:|..||.||:||.:.|.:..|.:....:|.::.|.:.|::|...:.||||.|:|
  Fly   452 EQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKP 516

  Fly   508 MPESIEDGENFGKGDTWFSQCAGRKKRQNSVYPDDPEQM-----VPLK 550
            |.|:|.|||.||            ||.:..||.:..:::     .|||
  Fly   517 MLETIADGERFG------------KKTKADVYLETGQELRAPEAQPLK 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	191/520 (37%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	142/382 (37%)
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	191/521 (37%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	141/376 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I682
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13331at6656
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm11112
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
	9	9.100