DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and CG16727

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_650818.1	Gene:	CG16727 / 42338	FlyBaseID:	FBgn0038719	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	132/574 - (22%)
Similarity:	244/574 - (42%)	Gaps:	67/574 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVDYVLEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSV 65
            |..|.|||    |.|.||::||:...|...:.:.:.:|..|...:...|||.|..:  |...|..
  Fly     1 MDFDRVLE----KCGNFGRFQFVILILYGYTNILSSLHYFSQTLITFTPEHWCSHD--DLMGLGA 59

  Fly    66 TPWNSSAILAAIPLKPNGELESCLMFDPSSPGTNTTI--NCERYVYDTTYYKTSRTIDWNFVCDR 128
            ....|        :..|....||.:......||....  :|:.::::......|.|.:..:|||:
  Fly    60 AELRS--------IYSNVSHPSCTLLSEVINGTGVASEESCQDWIFERENGYESLTTELKWVCDK 116

  Fly   129 RWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFS----FMVA 189
            ....|:.|:.|.||...|.::.|.|:|.:||......:||    .|....||..:..    |..:
  Fly   117 SHQPAVGQSFFFLGSVVGTISFGFLSDHIGRLPAMLMAAL----SGATGDFITSFVHTLPWFAFS 177

  Fly   190 RYLLGIVGSAGAYICGFVLTMELVGPTKRTV-CGITFQAVFAGGIML-------VAGWGALIPDR 246
            |::.|:......|:. ::|..|.:.|.:||. ..|.....:..|:|.       :..|...:
  Fly   178 RFVSGLSTDTMYYLM-YILVFEYLSPKRRTFGLNIILAVFYCFGLMTSPWIAMWIGNWRRYL--- 238

  Fly   247 QWLQ-------VIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIP---VD 301
             ||.       :||.|..|          ||.:||..:.:..|||..:.|..:.||..:.   .|
  Fly   239 -WLASLPALGVLIYPLLIC----------ESAQWLLTKKKYDEAVACLKKVAKFNGRQVEDSVFD 292

  Fly   302 K--EYYVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNP 364
            :  ::|.:|..:::...::....|. :|:||.||..|..:.:.....:|.|..::.:...|..:|
  Fly   293 EFVKHYREKMNEESKLNKQMDTFLG-MFKTPRLRRFTTTLLVKSVIITLSYDVINRNMEGLGSSP 356

  Fly   365 YLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAY-IAQGSTTSTAVVMA--- 425
            :.:..:...|..|:..||:.:.:::||:.:....:|.|.:...|..: ||....:..||::|
  Fly   357 FKLFSLTSSVYLPAGFTILLLQNKIGRKGMACGALLVGAIITAVTGFLIAVLDPSENAVLLALMV 421

  Fly   426 --GKLLIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGV 488
              |:.....|:.....|:||:.||.||..|:....:....|.:|...:..|..:...:|::...|
  Fly   422 GLGRFGTTVSYDAEIQYAAEIIPTSVRGQAVSNIHVVGLASSSLAFYVIYLAQYYKPLPSIFISV 486

  Fly   489 VALISGFWVMFLPETMNQPMPESIEDGENFGKGDT-WFSQCAGRKKRQNSVYPD 541
            :..:.....:.||||:::.:||::.|||.|...:: .:..|..:::...:.:.|
  Fly   487 LMFLGALLCLTLPETLHKKLPETLADGERFAMNESCLYFPCLHKRRESLTEHED 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	118/526 (22%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	88/400 (22%)
CG16727	NP_650818.1	2A0119	11..509	CDD:273328	119/527 (23%)
CG16727	NP_650818.1	MFS	125..499	CDD:119392	86/393 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	5	5.060