DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and CG14857

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	141/554 - (25%)
Similarity:	257/554 - (46%)	Gaps:	58/554 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVDYVLEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSV 65
            |..|.:||    |.|..|:||:|...|......|..:|..|...:..||:|.|:.|.::|.|...
  Fly     1 MDFDQILE----KCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFEE 61

  Fly    66 TPWNSSAILAAIPLKPNGELESCLMFDPSSPGTNTTIN---CERYVYDTTYYKTSRTIDWNFVCD 127
                    :||| ..|.|:..||...| ...|...|::   |:|::|:..:...|...:.|:||:
  Fly    62 --------IAAI-YAPFGKEASCTRLD-KIEGDRVTVSNETCQRWIYNYDFGFRSMNAELNWVCN 116

  Fly   128 RRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFS------- 185
            ..:...|.|::|.||...|..|.|.|.|::||        :..:|:.....|:.::.:
  Fly   117 DAYKARIGQSLFFLGSLMGTFTFGVLGDRIGR--------VRAVILANQCGFVGDFLTTYASNLV 173

  Fly   186 -FMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVC-----GITF--QAVFAGGIMLVAG-WGA 241
             |.:.|.:.|:..:|..|:. |:|.:|.:.|..|.:.     ||.|  .|:.|..:.::|| |..
  Fly   174 QFAIFRCISGLAATANYYLM-FILVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAGNWRI 237

  Fly   242 LIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGI-PVDKEYY 305
            .:.....||::..|       .::.:.||.:||..:.....|:..:......||..: ..|.|.:
  Fly   238 YLTCSALLQLVVAL-------FYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAF 295

  Fly   306 VQK--AKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLIL 368
            .:.  .|::.:.:.:.:||:.||.||||||..:|.|...:...||.:..:|.:...:..:|:::.
  Fly   296 RRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVF 360

  Fly   369 FIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGL--CCIVAAYIAQGSTTSTAVVMA----GK 427
            .:..:|..||......:..|:||::.....||..||  |.:..|...:|:..:..:::|    .:
  Fly   361 SLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMR 425

  Fly   428 LLIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALI 492
            |.|:..:.|...:::||.||.||:..:....:.|..:..::|.:..|.:.....|:::..::.|.
  Fly   426 LGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLT 490

  Fly   493 SGFWVMFLPETMNQPMPESIEDGENFGKGDTWFS 526
            :....:.||||.|:.:|.::.|||.||||::..|
  Fly   491 ASGCTLMLPETNNRQLPITLADGEAFGKGESMLS 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	127/522 (24%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	89/395 (23%)
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	128/523 (24%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	84/359 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	4	4.060