DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and slc22a6l

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_996960.2	Gene:	slc22a6l / 404609	ZFINID:	ZDB-GENE-040426-2249	Length:	560	Species:	Danio rerio

Alignment Length:	541	Identity:	180/541 - (33%)
Similarity:	272/541 - (50%)	Gaps:	36/541 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNSSAI 73
            ||:.::|..|::|.|...|..:..|....|.|....|||||.|.|    ..:::||::..::..:
Zfish     5 DLLEQVGSTGRFQVLHVTLLSMPILMMASHNLLQNFVAAVPPHHC----QPHANLSMSSTDAMDV 65

  Fly    74 L-AAIPLKPNGELESC-----------------LMFDPSSPGTNTTINCE-RYVYDTTYYKTSRT 119
            | |.:||..||:||.|                 .::|.|...|.|. :|| .:.|:.|...::..
Zfish    66 LRATVPLGLNGKLERCKRYTTPQWQILSLNTSESLWDESMAETETQ-SCEDGWFYNMTEMSSTII 129

  Fly   120 IDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYF 184
            .:|:.|||.|.:..:.||.:|.||..||:..|||:|:.||:.:...|.|...|.|..|||...:.
Zfish   130 TEWDLVCDYRALKQMSQTTYMGGVLVGAIVFGGLSDRFGRRVLLLISNLMMAIGGTCVAFSTSFT 194

  Fly   185 SFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQWL 249
            .|.|.|...|:..| |..:..|.|.:|.:....|||.|......:..|.:::|.....|.|.:||
Zfish   195 MFCVFRVCCGMALS-GLVLNSFSLIVEWIPTRVRTVVGTGTGYCYTTGQLILAAVAYCIRDWRWL 258

  Fly   250 QVIYGLHGCL-FLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRING---SGIPVDKEYYVQKAK 310
            .:...|...: ||..||:| ||.|||.:..:..:||..:....||||   .|..:|.|...:..|
Zfish   259 TLAVSLPFYVSFLYSWWFL-ESARWLVLTKKPEQAVKNLKTVARINGRSAEGDKIDLEMLQESMK 322

  Fly   311 QQAAAEEKSSAGLSDLFRTPNLRMKTLNVCL--CWFANSLVYYGLSLSAGKLYGNPYLILFIMGL 373
            ::.|..:.|.:.| ||.||..  |:|:.:||  .||:.|..|||||:...|...:.|||..|.|.
Zfish   323 KEMACSKGSYSAL-DLLRTST--MRTITICLSAVWFSTSFAYYGLSMDLQKFGVSIYLIQIIFGA 384

  Fly   374 VEFPSYITIVFVLDRLGRR-SITSTLMLGGGLCCIVAAYIAQGSTTSTAVVMAGKLLIAGSFAVI 437
            |:.|:.|.:...:..|||| |....|:|.|.:..|.....:......|::.:.||..:|.||...
Zfish   385 VDIPAKIIVTICMSMLGRRPSQCGALVLAGIMILINLLVPSDLQMLRTSLAVIGKGCLAASFNCC 449

  Fly   438 YNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLPE 502
            |.|:.||:|||:|.|.||..||.||....:.|::.||....|.||..::|...::||.:..||||
Zfish   450 YLYAGELYPTVIRQSGMGWVSMMARFGAMVAPMVLLLGDDYPWIPGFIYGGAPIVSGIFAFFLPE 514

  Fly   503 TMNQPMPESIEDGENFGKGDT 523
            |::||:|::|:|.::.|...|
Zfish   515 TLSQPLPDTIQDIDDRGLART 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	173/520 (33%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	128/377 (34%)
slc22a6l	NP_996960.2	2A0119	11..523	CDD:273328	174/521 (33%)
slc22a6l	NP_996960.2	MFS	116..513	CDD:119392	135/401 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.060