DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and slc22a4

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	540	Identity:	165/540 - (30%)
Similarity:	260/540 - (48%)	Gaps:	52/540 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DYVLEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFI-EGVDNSSLSVTP 67
            ||  :|:...||.:|.:|...|....:|.|..|...|.:|.|...|.|.|.| |.::.||:
Zfish     3 DY--DDITSFLGTWGPFQLTVFLALAISILPNGFVGLYIVFVGDTPAHECLIPEQINISSV---- 61

  Fly    68 WNSSAILAAIPLK-PNGELE--SC-------------LMFDPSSPGTNTTINCERYV----YDTT 112
            |..    ||||.: .:|.|:  ||             |.:.|:.....:.|..|..|    |...
Zfish    62 WRD----AAIPTQMQDGVLKRSSCSRYRLDTLRQLSMLNYTPNVEVNLSQIETEPCVDGWSYSQE 122

  Fly   113 YYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGV 177
            :|:::...:|:.||:|.:.|.:..:::..||..|....|.::|:.||:.|.......|.|..:..
Zfish   123 FYQSTIVTEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMALQTITILIQ 187

  Fly   178 AFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGAL 242
            .|.|.:..|....:.:|..|.:. |:..:||..|::.|..|.:.|       :.|:.:.:|.|.:
Zfish   188 MFSPSWEVFSAIYFFVGFSGFSN-YVVAYVLGSEILSPASRVLFG-------SLGVFMGSGIGQM 244

  Fly   243 --------IPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIP 299
                    |...:||.:...|.|.|:...||::.||||||..|||.|||..::.:....|....|
Zfish   245 FFPLAAYFIRSWRWLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRVTAP 309

  Fly   300 VDKEYYVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVC-LCWFANSLVYYGLSLSAGKLYGN 363
              :..:.....::||.:......:.|:....| .:.|:.:| |.|...::.||.|.|:...|:||
Zfish   310 --EVIFSSSEIEEAAKKRIQKHSILDILSNCN-AVSTILICSLLWMVITMSYYALILNTTNLHGN 371

  Fly   364 PYLILFIMGLVEFPSYITIVFVLDRLGRRSI-TSTLMLGGGLCCIVAAYIAQGSTTSTAVVMAGK 427
            |||..|:..:||.|:||....:|....||.. .|||:|||.|..|:.....:....:||:.|.||
Zfish   372 PYLNFFLSAVVEVPAYIIAALLLRFCSRRICQASTLLLGGALIFIIQLIPTELQGLATALEMLGK 436

  Fly   428 LLIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALI 492
            |.:..:|.|:|..::|||||||||.|||..||.||:...::|.|..|.::...||.::.|.:||.
Zfish   437 LCVTAAFCVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIYLGNYYRYIPYIVIGGLALF 501

  Fly   493 SGFWVMFLPETMNQPMPESI 512
            ||...:.|||:..:.:||:|
Zfish   502 SGVMSLLLPESKGKVLPETI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	158/525 (30%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	118/380 (31%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	159/526 (30%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	117/376 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.050