DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and SLC22A10

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001034841.3	Gene:	SLC22A10 / 387775	HGNCID:	18057	Length:	541	Species:	Homo sapiens

Alignment Length:	539	Identity:	144/539 - (26%)
Similarity:	249/539 - (46%)	Gaps:	39/539 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNSSA 72
            |:|:.::|..|::|.|.....:.|.:....|:|.....||:|.|||::..:||::.|   .|.:.
Human     4 EELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS---GNETG 65

  Fly    73 ILA-------AIPLKPNGELESCLMF-DP------------SSPGTNTTINCERYVYDTTYYKTS 117
            ||:       :|||..|...|.|..| .|            |:...:|....:.:|||.:|:.::
Human    66 ILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGWVYDQSYFPST 130

  Fly   118 RTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPE 182
            ....|:.|||.:.:.::||.:.:.|:..|.:..|.::|:.||:.:..|..|...|.....||.|.
Human   131 IVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLAITDTCAAFAPT 195

  Fly   183 YFSFMVARYLLGIVGSAGAYICGFVLTM-ELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDR 246
            :..:.|.|:|.|.  |:...|....|.: |.:.|..:.:..|......:.|.:::.|...:..|.
Human   196 FPVYCVLRFLAGF--SSMIIISNNSLPITEWIRPNSKALVVILSSGALSIGQIILGGLAYVFRDW 258

  Fly   247 QWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRING-------SGIPVDKEY 304
            |.|.|:..:...:|.....||.||.|||.:..:..|.:..:.|..|.||       ..|.|
Human   259 QTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVARTNGIKNAEETLNIEV---- 319

  Fly   305 YVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILF 369
             |:...|:.....::...:.||||.|::|.:...:....|||::.:||..::...:..|.:|:..
Human   320 -VRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFYGTMVNLQHVGSNIFLLQV 383

  Fly   370 IMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYI-AQGSTTSTAVVMAGKLLIAGS 433
            :.|.|........:..|:.:|||......|...||..:...:: .:..|...|:...|....|.:
Human   384 LYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANTFVPKEMQTLRVALACLGIGCSAAT 448

  Fly   434 FAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVM 498
            |:.:..:..||.|||:|..|.|:....:|:..||.||:..|..|...:|.:::|:..:|.|..|.
Human   449 FSSVAVHFIELIPTVLRARASGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVF 513

  Fly   499 FLPETMNQPMPESIEDGEN 517
            .||||.|.|:|::|:|.||
Human   514 LLPETKNLPLPDTIKDVEN 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	137/523 (26%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	94/379 (25%)
SLC22A10	NP_001034841.3	2A0119	11..526	CDD:273328	138/524 (26%)
SLC22A10	NP_001034841.3	MFS	143..516	CDD:119392	94/379 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010