DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and CG42269

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	149/580 - (25%)
Similarity:	274/580 - (47%)	Gaps:	49/580 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AVDYVLEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPE-HRCFIEGVDNSSLSV 65
            ::|:  :|::..:||||:||.|.|...:...........|.:.:..:|| |.|.:..:|...:
  Fly    69 SMDF--DDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDV-- 129

  Fly    66 TPWNSSAILAAIPLKPNGELESCLMF---------------DPSSPGTNTTINCER---YVYDTT 112
                .:.:..:||: .|||..:|.|:               ||..|    .:.|..   |.:...
  Fly   130 ----EARLALSIPM-TNGEYNNCYMYDVNYTDILAQGKVMADPKWP----QVKCRHGWSYNFTEI 185

  Fly   113 YYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGV 177
            .|.|..| :.|:|||...:....|::|.||...|.:..|.:||:.||......:.:..|:.|||.
  Fly   186 PYATVAT-EQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGT 249

  Fly   178 AFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRT-VCGITFQAVFAGGIMLVAGWGA 241
            ||:..::.|.:.|:.:|.... ..:...::|.:|.|||..|| |..::....|.|...|:.....
  Fly   250 AFVSNFWEFAIMRFFVGFAFD-NCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAY 313

  Fly   242 LIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDKEYYV 306
            .:.|.:.|.::......|.:...:.:.||.|||..||:..:||.|:.|..:.||..:| .:.|.:
  Fly   314 FLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVP-PQTYQI 377

  Fly   307 -----QKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYL 366
                 ::.::|.|...|.|  :.|||::|.||..||.:.:.|.|.|||:.|...:.|.|..:.:.
  Fly   378 FTDSCKRMQEQEAQNGKYS--VLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFF 440

  Fly   367 ILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQGSTTSTAVVMAGKLLIA 431
            ...:....|.|:...:..:|||.|||.:..:.|:..|:..::|..:..| ..|.|:.:.|:..:.
  Fly   441 TFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVG-IYSAALAIMGRFFVN 504

  Fly   432 GSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFW 496
            .|:.:...::||:.|||||..|:....:...::..:.|.:..|.:....:|.::.|::.:|.|..
  Fly   505 ISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLL 569

  Fly   497 VMFLPETMNQPMPESIEDGENFGKGDT-WFSQCAGRKKRQNSVYPDDPEQMVPLKNIESK 555
            .:.||||:|..:|:::.|||.||:|.: |...|..::...:    :|.::...::.:.|:
  Fly   570 ALLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDD----EDEKRNADVEEVRSQ 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	136/519 (26%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	98/376 (26%)
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	127/488 (26%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	93/343 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	6.060