DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and CG10486

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	143/571 - (25%)
Similarity:	246/571 - (43%)	Gaps:	62/571 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DYV-LEDLMGKLGEFGKYQFLQF-FLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVT 66
            ||: .:||:..:|:||::|...| |:.....:||.:::..:......|::.|::     ..|..|
  Fly    92 DYIDFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYV-----PELLHT 151

  Fly    67 PWNSSAILAAIPLKPNGELESCLMFDPS----------SPGTNT---TINCER-YVYDTTYYK-T 116
            |......| :||.:.:|....|.|::.:          |...||   ||.|:: ||::..... .
  Fly   152 PVELRKEL-SIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAFE 215

  Fly   117 SRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIP 181
            |.|:::.::||........|.:|.||...|.:..|..||..||......|....|:..:..:...
  Fly   216 SATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMST 280

  Fly   182 EYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDR 246
            ::|:|.::|:|:| ......:...::|.:|.|||..||:......|:|.....:|..|.||...
  Fly   281 DFFTFAISRFLVG-ASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAG- 343

  Fly   247 QW--------LQVIYGLHG-CLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDK 302
            .|        |.::..:.. ||       |.||.|||...|...:|::|:...:.:|...:..:.
  Fly   344 NWRRFSSFTSLPIVLAMFSFCL-------LPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEI 401

  Fly   303 EYYVQKAKQQAAAEEKSSAGLS--DLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYG-NP 364
            ....:.:..|...||......:  .:|:...:....:.:.|.|.:.||||.|...:|..|.. |.
  Fly   402 LDLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENI 466

  Fly   365 YLILFIMGLVEFPSYITIVFVLDRLGRR--SITSTLMLGGGLCCIVAAYIAQGSTTSTAVVMAGK 427
            :|...|....|.|..|.::..|||.|||  |...| .|.|....:.|::..:.:...:|
  Fly   467 FLFFTIACATELPGNILVILTLDRAGRRWCSFFYT-SLSGVFSLLGASFQNRANMRMSA------ 524

  Fly   428 LLIAGSF--AVIYN----YSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLF 486
              :||.|  .:.||    ::||:.|||||...:........::..::|.:..|.........::.
  Fly   525 --LAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVL 587

  Fly   487 GVVALISGFWVMFLPETMNQPMPESIEDGENFGKGD-TWFSQCAGRKKRQN 536
            |.:.:..|...:|||||:|..:||::.||..|||.. .|...|.|...|::
  Fly   588 GALGIFGGLLALFLPETLNHELPETLSDGAQFGKNQRIWHMPCCGPGSRKS 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	128/530 (24%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	92/390 (24%)
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	129/531 (24%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	92/388 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	6.060