DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and CG5592

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	132/559 - (23%)
Similarity:	249/559 - (44%)	Gaps:	67/559 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EDLMGKLGEFGKYQ-FLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFI---EGVDNSSLSVTPW 68
            |:.:..:|:||.:| .|.|::...:.|.|..:...:..:.....|.|.:   ||:..|...
  Fly    10 ENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQK---- 70

  Fly    69 NSSAILAAIPLKPNGELESCLMFDP--SSPGTN------TTINCER-YVYD--TTYYKTSRTIDW 122
                 ...||.|.:|..|:|.|::.  .|..||      :.|.|.. ::||  ...|::..| ::
  Fly    71 -----NRGIPKKQDGSFENCFMYNVPYDSNATNDANQTRSPIPCNNGWIYDRKEVPYESIAT-EY 129

  Fly   123 NFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFM 187
            |:|||:|..|.....|:.:|...|.:..|.:.|..||......:....:|.|.......::..|.
  Fly   130 NWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFA 194

  Fly   188 VARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCG---ITFQAVFAGGIMLVAGWGALIPDRQW- 248
            .:|::.|: .....::..::||:|.||...||:.|   :||  .|..|..|:. |.|.:.. .|
  Fly   195 ASRFVAGL-SMNYCFVPIYILTLENVGIKYRTLVGNLALTF--FFTLGACLLP-WLAYVIS-NWR 254

  Fly   249 -------LQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVD----- 301
                   |.:::.:...|.      ..|||.||...|:....::::.:..:.||..|..:
  Fly   255 HYAMVVALPIVFMILTSLL------APESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEM 313

  Fly   302 KEYYVQKAKQQAAAEEKSSAGLSDLFRT-PNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPY 365
            :|.|..|...:...::.:|.   |||:| |.|.:.|: :.:.|...:|.|.........|..:.:
  Fly   314 RECYELKFANEQLGKQYTSL---DLFKTFPRLVVLTI-LIVTWMTVALAYDAHVRVVEILDTDIF 374

  Fly   366 LILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAY--IAQGSTTSTAVVMAGKL 428
            :...:..|||.|:.|..:.:|||:||:.:.|.:||   ||...:.:  |.:|...::...:|.:.
  Fly   375 ITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVML---LCAASSLFVGILKGHWNASTAAIAARF 436

  Fly   429 LIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALIS 493
            ....::.|...:::|:.|||:|...:.:.::..::...|:||:.....:...:|..:..:|::|.
  Fly   437 FATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIG 501

  Fly   494 GFWVMFLPETMNQPMPESIEDGENFGKGDTWFSQCAGRK 532
            ...::|||||....||:::::.|.     .|..:|..||
  Fly   502 ALIILFLPETKGATMPQTLDEAEK-----RWTLRCRDRK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	125/528 (24%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	86/389 (22%)
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	126/529 (24%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	85/385 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	5	5.060