DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001032838.1	Gene:	Slc22a14 / 382113	MGIID:	2685974	Length:	629	Species:	Mus musculus

Alignment Length:	571	Identity:	135/571 - (23%)
Similarity:	254/571 - (44%)	Gaps:	61/571 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AVDYVLED----LMGKLGEFGKYQF----LQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEG- 57
            |:|...:|    :|..:||||.:|:    |.|...:||......|...|............:|.
Mouse    42 AIDARRDDKFASVMDAIGEFGTFQWRLVVLTFIPSILSTFFIFSHHFLLTAQRPYCNTSWILEVG 106

  Fly    58 ---VDNSSLSVTPWNSSAILAAIPLKPNGELESCLMFDPSSP---------GTNTTINCE-RYVY 109
               .::..|::|          :|..|||...:|||:.| .|         |.|.|..|: .::|
Mouse   107 PNLTEDEQLNLT----------LPRAPNGSFLTCLMYIP-VPWDLDSIIHFGLNYTETCKFGWIY 160

  Fly   110 DTTYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIG 174
            ...:.: |...:::.||..........|||:.||.||::..|.|:||:||..:...|.|..||.|
Mouse   161 PFAHTR-SLINEFDLVCGNEPNKENGLTVFLSGVLTGSLLFGFLSDKLGRYPIILLSLLGFLIFG 224

  Fly   175 VGVAFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGW 239
            .|.||:..::.::..|:.:. ..|.|..||...|.||.:....|....|...:....|::|:.|.
Mouse   225 FGTAFVSSFYQYLFFRFFVA-QASVGYAICSVSLVMEWLVGEHRAQAVILQHSFLTIGVILLTGL 288

  Fly   240 GALIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDKEY 304
            ...:...:.|.::.|:.....:.:.|.|.||||||.::|:..||..::.....:|...||::
Mouse   289 AYKVVHWRLLCLLGGMPMFPLICNIWVLRESPRWLMVRGKVEEAKKVLCYAAEVNKKTIPLN--- 350

  Fly   305 YVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILF 369
              ...:.|.:.::.:.|.:.|.....:|....|.:...||..|.:.:.|:|.......:.|.:..
Mouse   351 --LLNELQISGKKVAKASILDFCTNQHLFKVVLAIGCVWFTVSYISFTLNLKMNDFGLDVYFVQM 413

  Fly   370 IMGLVEFPSYITIVFVLDRLGRR-SITSTLMLGGGLCCIVAAYIAQGSTTSTAVVMAGKLLIAGS 433
            :..:|..|:.:..:.:|:..||: ::..||.|...:|..:.....:..:|....:|..:..:||:
Mouse   414 VRSIVAVPARLCCIILLEYFGRKWALNLTLFLVTSMCLFLLFLPQEPKSTIILTLMLAEFSMAGT 478

  Fly   434 FAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVM 498
            .::.:.|:|||.|||:|::.:|:.|: |.::||::. :.:......::|.....:..:::..:..
Mouse   479 LSIFFIYTAELLPTVLRSTGLGMVSL-AWVAGAISS-VAIFKQTKTQLPIFFCCLCCVLALCFSS 541

  Fly   499 FLPETMNQPMPESIEDGENFGKGDTWFSQCAGRKKRQNSVYPDDPEQMVPL 549
            .:|||.:|.:.:|||                  ...::|:.|.|..:.||:
Mouse   542 LVPETGSQSLRDSIE------------------YNIRDSIEPKDRNKDVPM 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	123/513 (24%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	88/371 (24%)
Slc22a14	NP_001032838.1	2A0119	59..553	CDD:273328	123/513 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020