DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_941052.1	Gene:	Slc22a20 / 381203	MGIID:	2685809	Length:	556	Species:	Mus musculus

Alignment Length:	558	Identity:	181/558 - (32%)
Similarity:	274/558 - (49%)	Gaps:	46/558 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DLMGKLGEFGKYQFLQFFLQVL-SGLTAGMHMLSLVTVAAVPEHRC-----FIEGVDNSSLSVTP 67
            ||:..||..|::|.:...|.:| .||.|....|...| ||.|.|.|     :.|...|.|   ..
Mouse     5 DLLDALGGVGRFQLVYTALLLLPCGLLACHTFLQNFT-AAAPPHHCQHPANYTEPTTNVS---GV 65

  Fly    68 WNSSAILAAIPLKPNGELESCLMF----------DPSSPGTNTTINCERYVYDTTYYKTSRTIDW 122
            |    :.|||||..:|:.|.|..:          :.||.|..|....:.:|||.:.:.::..::|
Mouse    66 W----LRAAIPLNQHGDPEPCRRYVEPQWALLKPNASSHGVATEGCKDGWVYDRSIFPSTIVMEW 126

  Fly   123 NFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFM 187
            :.||:.|.:..:.|:::|.||..||...|||||::|||....||.|...:.|...|::..:.::.
Mouse   127 DLVCEARTLRDLAQSIYMSGVLVGAALFGGLADRLGRKAPLVWSYLQLAVSGAATAYVGSFSAYC 191

  Fly   188 VARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQWLQVI 252
            |.|:|:|:..| |..:....|.:|.:....|||.||.....|..|.:::||...||...:|||..
Mouse   192 VFRFLMGMTFS-GIILNSLSLVVEWMPTRGRTVAGILLGFSFTLGQLILAGVAYLIRPWRWLQFA 255

  Fly   253 YGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRING---SGIPVDKEYYVQKAKQQAA 314
            ......:|..:.|||.||.|||.:.|:|.:||..:.|...:||   .|..:..| .|....|...
Mouse   256 VSAPFLVFFLYSWWLPESSRWLLLHGKAQQAVQNLQKVAMMNGRKAEGERLTTE-VVSSYIQDEF 319

  Fly   315 AEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMGLVEFPSY 379
            |..::|..:.||||||.:|..|..:...||:||:.||||::...|...:.||:..:.|:::.|:.
Mouse   320 ASVRTSNSILDLFRTPAIRRVTCCLMGVWFSNSVAYYGLAMDLQKFGLSIYLVQALFGIIDIPAM 384

  Fly   380 ITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQG-STTSTAVVMAGKLLIAGSFAVIYNYSAE 443
            :.....:..:|||:..|:.::..||..|...::.:. .|..|.....||..:|.||..:|.::.|
Mouse   385 LVATTTMIYVGRRATVSSFLILAGLMVIANMFMPEDLQTLRTVQAALGKGCLASSFICVYLFTGE 449

  Fly   444 LFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWV-MFLPETMNQP 507
            |:||.:|...||..|:.|||.|.:.||||.|....|.:|.|.||..::::|..| .||.||.|.|
Mouse   450 LYPTEIRQMGMGFASVNARLGGLVAPLITTLGEISPVLPPVSFGATSVLAGMAVACFLTETRNVP 514

  Fly   508 MPESIEDGENFGKGDTWFSQCAGRKKRQNSVYPDDPEQ 545
            :.|:|...|...|        .||.||       |.||
Mouse   515 LVETIAAMERRVK--------QGRSKR-------DTEQ 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	167/515 (32%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	124/375 (33%)
Slc22a20	NP_941052.1	2A0119	11..518	CDD:273328	167/516 (32%)
		MFS	138..507	CDD:119392	123/370 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..556		8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060