DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_038941497.1	Gene:	Slc22a12 / 365398	RGDID:	621628	Length:	578	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	166/562 - (29%)
Similarity:	274/562 - (48%)	Gaps:	68/562 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DLMGKLGEFGKYQFLQFFLQVLSGL-TAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVT---PWN 69
            :|:.::|..|::|.||....|...| ....:||...: ||||.|||::..:|||:...:   .:.
  Rat     5 ELLDRVGGRGRFQLLQAVALVTPILWVTTQNMLENFS-AAVPHHRCWVPLLDNSTSQASIPGDFG 68

  Fly    70 SSAILA-AIPLKPNGELESCLMF--------DPSSPGTN----TTINCE-RYVYDTTYYKTSRTI 120
            ...:|| :||..|:.....||.|        :.::..||    .|..|| .:|||.:.::::...
  Rat    69 RDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIESNTTATNWSDADTEPCEDGWVYDHSTFRSTIVT 133

  Fly   121 DWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEY-- 183
            .|:.|||.:.:..:.|::|:.|:..||...|..:|:.||:.|..||.|...:.|...|.:|.:
  Rat   134 TWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTIAALMPTFPL 198

  Fly   184 ---FSFMVARYLLGIVGSAGAYIC---------GFVLTMEL---------------VGPTKRTV- 220
               |.|:||..:.|::.:. |.:|         |::...||               .||...|:
  Rat   199 YCLFRFLVASAVAGVMMNT-ASLCMFPVVLGREGYMQDPELTPSLLLAVMEWTSAQAGPLMMTLN 262

  Fly   221 -CGITFQAVFAGGIMLVAGWGALIPDRQW--LQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAE 282
             .|.:|..|..|.:    .:|.    |.|  ||:.......||..:.|||.||.|||...||..:
  Rat   263 ALGFSFGQVLTGSV----AYGV----RSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGRLDQ 319

  Fly   283 AVDIVAKGLRINGSGIPVD--KEYYVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFA 345
            ::..:.:...:|......|  ....::.|.|:.....::.|.|..|..||.||::|....|||||
  Rat   320 SLRELQRVAAVNRRKAEADTLTVEVLRSAMQEEPNGNQAGARLGTLLHTPGLRLRTFISMLCWFA 384

  Fly   346 NSLVYYGLSLSAGKLYGNPYLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAA 410
            ....:|||:|....|..|.:|:..::|:|:.|..:..:.:|.|||||...::.::..|||.:...
  Rat   385 FGFTFYGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGRRLCQASSLVLPGLCILANI 449

  Fly   411 YIAQGS---TTSTAVVMAGKLLIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLIT 472
            .:.:..   .:|.||:..|.|  ..:|..:..:|:||||||:|.:|:|||.:.||....|.||:.
  Rat   450 LVPREMGILRSSLAVLGLGSL--GAAFTCVTIFSSELFPTVIRMTAVGLGQVAARGGAMLGPLVR 512

  Fly   473 LLDSFDPKIPAVLFGVVALISGFWVMFLPETMNQPMPESIED 514
            ||..:...:|.:::|||.::||...:.||||.|.|:|::|:|
  Rat   513 LLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQD 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	162/550 (29%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	117/408 (29%)
Slc22a12	XP_038941497.1	MFS_OAT	109..541	CDD:340932	127/442 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030