DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and Slc22a15

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001101177.1	Gene:	Slc22a15 / 310732	RGDID:	1311184	Length:	548	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	159/535 - (29%)
Similarity:	251/535 - (46%)	Gaps:	69/535 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LEDLMGKLGEFGKYQ-FLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNS 70
            :|:....:||.|.|| :|.|.|.||..|......:.:..:.|.|.:.               |:.
  Rat     3 VEEAFQAVGEMGLYQMYLCFLLAVLLQLYVATEAILIALIGATPAYH---------------WDM 52

  Fly    71 SAILAAIPLKPNGELESCLMFDPSSPG--------TNTTINCERYVYDTTYYKTSRTIDWNFVCD 127
            :.:|      ||....:    ..|..|        |.......::|:.:..: ||...:|..:.:
  Rat    53 AELL------PNQSHSN----QSSGKGQAFGDWLLTANGSEIHKHVHFSNSF-TSIASEWFLIAN 106

  Fly   128 RRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFMVARYL 192
            |.:..:...:.|..|||.|.::.|.|:|:.|||.|:.......::..:...|.|.|..|.|.|:|
  Rat   107 RSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFL 171

  Fly   193 LGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQW--LQVIYGL 255
            :|:: :.|..:..|||..|.||.....:.|......||.||...|..|..|  |.|  |.::..|
  Rat   172 VGMM-NGGMSLVAFVLLNECVGAAYWALAGSIGGLFFAVGIAQYALLGYFI--RSWRTLAILVNL 233

  Fly   256 HGCLFLGHWWWLDESPRWLWMQGR---AAEAVDIVAK---GLRINGS-GIPVDKEYYVQKAKQQA 313
            .|.:......::.||||||:.|||   |.||:.::||   .|:...| ..|.::.|
  Rat   234 QGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSY--------- 289

  Fly   314 AAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMGLVEFPS 378
                :.:....||||...|...||.:...||..|||||||:||||.|.|:.|..|.:.||:|.||
  Rat   290 ----RETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPS 350

  Fly   379 YITIVFVLDR--LGRRSITSTLMLGGGLCCIVAAYIAQGSTTST-AVV------MAGKLLIAGSF 434
            |...::::::  .||:...:..:..|||.|::..::.:...|.. |||      :.|||.|:.:|
  Rat   351 YPLCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAF 415

  Fly   435 AVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMF 499
            .::|.|::||:|||:||..:|..||.:|:.|.:.|.:..|......:|.::||...|.||...:.
  Rat   416 NIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFVPSLKDVQWSLPFIVFGATGLTSGLLSLL 480

  Fly   500 LPETMNQPMPESIED 514
            ||||:|.|:.|:..|
  Rat   481 LPETLNSPLLETFSD 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	156/521 (30%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	125/388 (32%)
Slc22a15	NP_001101177.1	MFS	111..469	CDD:119392	121/373 (32%)
Slc22a15	NP_001101177.1	MFS_1	111..450	CDD:284993	117/354 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	272	1.000	Domainoid score	I1731
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930