DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	166/539 - (30%)
Similarity:	277/539 - (51%)	Gaps:	48/539 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DYVLEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPW 68
            ||  :::...|||:|.:|.|.|||...|.:..|.:.:|:|.:|..|||||.:....|.|   :.|
  Rat     3 DY--DEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLS---SAW 62

  Fly    69 NSSAILAAIPL--KPNGEL-ESCLMFDPSS----------PGTNTTI------NC-ERYVYDTTY 113
            .:.    :|||  |...:: :||..:..::          ||.:..:      || :.:.|:...
  Rat    63 RNH----SIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNKDV 123

  Fly   114 YKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGV--G 176
            :.::...:|:.||...|...:..::|.:||..|:...|.|:|:.|||.|     || |.:|:  |
  Rat   124 FLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNV-----LF-LTMGMQTG 182

  Fly   177 VAFIPEYFS-----FMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVF-AGGIML 235
            .:|: :.||     |.|...|:| :|....|:..|||..|::..:.|.:.......:| |.|.|:
  Rat   183 FSFL-QLFSVNFEMFTVLFVLVG-MGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMV 245

  Fly   236 VAGWGALIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPV 300
            :..:...|.|.:.|.:...:.|.|....||::.||||||..|||..||..|:.|..:.|  ||..
  Rat   246 LPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFN--GIVA 308

  Fly   301 DKEYYVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPY 365
            ....:.....|...:::..|..:.||.||.|:|:.|:...:.|...|:.|:||||....|:|:.|
  Rat   309 PSTIFDPSELQDLNSKKPQSHHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIY 373

  Fly   366 LILFIMGLVEFPSYITIVFVLDRLGRR-SITSTLMLGGGLCCIVAAYIAQGSTTSTAVVMAGKLL 429
            :..|::..||.|:|:....:|..|.|| ||::.|.|||.:...:....::....|||:||.||..
  Rat   374 VNCFLLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLLFIQLVPSELFYLSTALVMVGKFG 438

  Fly   430 IAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISG 494
            |..:::::|.|:|||:||||||..:|:.|..:||...|:|....|.::|..:|.:|.|.:.:::.
  Rat   439 ITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTA 503

  Fly   495 FWVMFLPETMNQPMPESIE 513
            ...:|.||:...|:|::|:
  Rat   504 ILTLFFPESFGAPLPDTID 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	161/523 (31%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	123/379 (32%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	162/524 (31%)
		MFS	123..510	CDD:119392	126/396 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm12322
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020