DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	173/563 - (30%)
Similarity:	275/563 - (48%)	Gaps:	53/563 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEH-------------RCFIEGVD 59
            :..:.|.||||::|...|.|..|:|:|.....:.:|.:.:.|::             ||
  Rat     5 DQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERC------ 63

  Fly    60 NSSLSVTP---WNSSAILAAIPLKPNGELESCLMFDPSSPGTNTTINCERYVY------------ 109
                :.:|   ||.:.....:|.:..|: ..|..:......|::.::|:....
  Rat    64 ----AWSPEEEWNLTTPELHVPAERRGQ-GHCHRYLLEDTNTSSELSCDPLAAFPNRSAPLVPCS 123

  Fly   110 -DTTYYKTSRTI--DWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQL 171
             |..|.:|..||  .::.||...||..:.|.:..||...||.|||..||:.||..|:..|.....
  Rat   124 GDWRYVETHSTIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLISCFGVG 188

  Fly   172 IIGVGVAFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLV 236
            |.||.|||.|.:..|::.|:|.|:.|. ||::..||:..|:||..:|.:.||..|..|..||:::
  Rat   189 ITGVVVAFAPNFSVFVIFRFLQGVFGK-GAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGIIIL 252

  Fly   237 AGWGALIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVD 301
            .|.....|..|.:|:...|...|||.::|.:.||||||..:.:..:|:.|:.:..:.||
  Rat   253 PGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNG------ 311

  Fly   302 KEYYVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYL 366
            |......::.....||.|:....||.|||.:|..||.:...||.:::||.||.:..|.:.||.|:
  Rat   312 KHLSSNYSEITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYM 376

  Fly   367 ILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQG-STTSTAVVMAGKLLI 430
            ..||.||||.|..:.|:..::|||||...:...:..|:.|:|.|::.:| ....|.|...|:|.|
  Rat   377 DFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTVATLGRLGI 441

  Fly   431 AGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTP-LITLLDSFDPKIPAVLFGVVALISG 494
            ..:|.::|..::||:||.:||..:.|.|......|.:.| |:..|.:...::|.::||::|.:.|
  Rat   442 TMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCG 506

  Fly   495 FWVMFLPETMNQPMPESIEDGENFGKGDTWFSQCAGRKKRQNS 537
            ..||.||||....:||::||.|..|...  ..||..:||.|.|
  Rat   507 GLVMLLPETKGIALPETVEDVEKLGSSQ--LHQCGRKKKTQVS 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	160/527 (30%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	127/372 (34%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	161/528 (30%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	127/374 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	272	1.000	Domainoid score	I1731
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.030