DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and Slc22a2

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_113772.1	Gene:	Slc22a2 / 29503	RGDID:	61936	Length:	593	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	176/578 - (30%)
Similarity:	284/578 - (49%)	Gaps:	52/578 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LEDLMGKLGEFGKYQFLQFF-LQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNS 70
            ::|::..:|||..:|...|| |.:|||....:: :.:|.:...|:|.|:..|....| ....|:.
  Rat     4 VDDILEHIGEFHLFQKQTFFLLALLSGAFTPIY-VGIVFLGFTPDHHCWSPGAAKLS-QRCGWSQ 66

  Fly    71 SAIL-AAIP-LKPNGE---LESCLMFDPSSPGTNTTINC--------------------ERYVYD 110
            :..| ..:| |.|:.|   |..|:.::..  ...:|::|                    ..:||:
  Rat    67 AEELNYTVPGLGPSDEASFLSQCMRYEVD--WNQSTLDCVDPLSSLAADRNQLPLGPCEHGWVYN 129

  Fly   111 TTYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGV 175
            |.  .:|...::|.||...||..:.|:|..:|.|.||:.:|.|||:.|||.....:.|...|.|.
  Rat   130 TP--GSSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCLLVTILINAISGA 192

  Fly   176 GVAFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWG 240
            .:|..|.|...:|.|:|.|:|..|| ::.|::|..|.||...|.:.||.:|..|..|::::||..
  Rat   193 LMAISPNYAWMLVFRFLQGLVSKAG-WLIGYILITEFVGLGYRRMVGICYQIAFTVGLLILAGVA 256

  Fly   241 ALIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDKEYY 305
            .:||:.:|||....|....||.::|.:.||||||..|.:..:|:.|:....:.||..:||.
  Rat   257 YVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKNGKSVPVS---- 317

  Fly   306 VQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFI 370
            :|.......|.:|....:.||.|||.:|..||.:...||.:|::|.||.:..|....|.||..|.
  Rat   318 LQNLTPDEDAGKKLKPSILDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFY 382

  Fly   371 MGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQG-STTSTAVVMAGKLLIAGSF 434
            ..|||||:...|:..:||:|||...:...:..|..|:.:.:|... ......:...|::.|..::
  Rat   383 SALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLASVFIPDDLQWLKITIACLGRMGITMAY 447

  Fly   435 AVIYNYSAELFPTVVRN-SAMGLGSMCARLSGALTP-LITLLDSFDPKIPAVLFGVVALISGFWV 497
            .::...:|||:||.:|| ..:...||| .:.|.:|| |:..|.....:.|.|:|.||.|::|..|
  Rat   448 EMVCLVNAELYPTYIRNLGVLVCSSMC-DIGGIITPFLVYRLTDIWMEFPLVVFAVVGLVAGALV 511

  Fly   498 MFLPETMNQPMPESIEDGENFGKGDTWFSQCAGRKKRQNSVYPDD---PEQMVPLKNI 552
            :.||||..:.:||:|||.||.        |...:|:|:.::.|..   |...:..|.|
  Rat   512 LLLPETKGKALPETIEDAENM--------QRPRKKERKENLPPSQASRPSAKLKRKGI 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	161/523 (31%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	124/373 (33%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	162/524 (31%)
Slc22a2	NP_113772.1	MFS	125..492	CDD:119392	123/374 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	272	1.000	Domainoid score	I1731
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.030